JamunJar: Health & Wealth for a better tomorrow

🧪 Appendix Biopsy – Large (3–6 cm)

Parameter	Details
Specimen Type	Tissue biopsy (appendix or suspected appendiceal mass)
Sample Size	Large biopsy (3–6 cm)
Common Method	Histopathology (Hematoxylin & Eosin stain), Immunohistochemistry
Turnaround Time	3–7 days (depending on complexity and ancillary tests)
Fasting Required	❌ No (but may be part of a pre-surgical protocol)

🧬 What Is This Test?

A large biopsy of the appendix (3–6 cm) involves the surgical removal and pathological examination of a sizable tissue segment from the appendix, often performed:

Post-appendectomy (for suspected appendicitis, tumors, or mass lesions)
During laparoscopy/laparotomy for abdominal pain or unexplained mass
In cancer staging or diagnostic investigation of mucinous lesions

🧠 Organs Involved

Organ	Involvement
Appendix	Site of biopsy, prone to inflammation, infection, or tumors
Peritoneum	May be involved in mucinous neoplasms or perforated appendix
Colon	Anatomically and histologically assessed in differential diagnosis

🎯 Why Is This Test Done?

Purpose	Details
✅ Diagnose appendicitis variants	Acute, chronic, or gangrenous inflammation
🔬 Identify tumors or carcinoids	Includes neuroendocrine tumors, adenocarcinoma, mucinous neoplasms
🧫 Detect infection or granulomas	From tuberculosis, Crohn’s, or parasitic origin
🧪 Confirm mucinous appendiceal neoplasm	To rule out pseudomyxoma peritonei or low-grade appendiceal neoplasms (LAMN)

🔍 What Is Evaluated in the Biopsy?

Microscopic Features Examined	Purpose
Inflammatory cell types	Acute vs chronic inflammation
Epithelial architecture	Dysplasia, mucin production, glandular pattern
Tumor cell markers (IHC)	Chromogranin A, Synaptophysin (for carcinoid); CK20, CDX2 for adenocarcinoma
Granulomas or necrosis	For TB, Crohn’s, fungal infections
Margins & perforation	Assess for complete excision or complications

🧬 Common Conditions Investigated

Condition	Relevance to Biopsy
Acute appendicitis	Confirmed by neutrophilic infiltration, mucosal ulceration
Carcinoid tumor (neuroendocrine)	Most common appendix tumor; may be incidental
Mucinous neoplasm	Associated with pseudomyxoma peritonei risk
Adenocarcinoma	Rare but serious; treated like colorectal cancer
Tuberculosis or Crohn’s disease	Chronic granulomatous inflammation

🔁 Recommended Additional Tests

Test	Why It's Done
CEA, CA 19-9	Tumor markers if malignancy is suspected
CT Abdomen / MRI	Pre- or post-operative mass localization and metastasis assessment
IHC (Immunohistochemistry)	Differentiates between tumor subtypes
Colonoscopic Biopsy	If colon involvement is suspected
Gene panels (if adenocarcinoma)	For KRAS, BRAF mutations in advanced cases

📌 Summary Table

Parameter	Details
Test	Appendix Biopsy (Large, 3–6 cm)
Sample	Appendix tissue (post-surgery or guided biopsy)
Key Uses	Diagnose appendicitis, tumors, mucinous lesions, infection
Common Findings	Inflammation, neuroendocrine tumors, mucin, granulomas
Associated Organs	Appendix, colon, peritoneum
Next Steps	Imaging, tumor markers, IHC, colonoscopy (if required)

Appendix -Large Biopsy 3-6 cm

1000+ Booked this Test