Cervix biopsy -Medium 1-3 cm
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Evaluation of abnormal Pap smear, diagnosis of precancerous or cancerous lesions
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🧬 Cervix Biopsy – Medium (1–3 cm)
🧪 Test Name: Cervical Biopsy – Medium Tissue Sample
Parameter | Details |
|---|---|
Sample Type | Cervical tissue (1–3 cm) collected via punch biopsy, cone biopsy, or LEEP |
Fasting Required | ❌ Not required |
Organ Involved | Cervix (lower part of the uterus) |
Primary Use | Evaluation of abnormal Pap smear, diagnosis of precancerous or cancerous lesions |
Clinical Department | Gynecology / Oncology / Pathology |
🔍 Why is This Test Done?
A cervical biopsy is performed when:
- Pap smear shows abnormal cells (ASC-US, LSIL, HSIL)
- Visual lesions are observed on colposcopy
- There is unexplained post-coital bleeding, discharge, or cervical erosion
- HPV infection is persistent, especially with high-risk strains
🔬 What Does the Biopsy Detect?
Detected Conditions | Description |
|---|---|
Cervical Intraepithelial Neoplasia (CIN) | Precancerous changes graded as CIN I, II, or III |
Cervical Cancer (SCC, Adenocarcinoma) | Squamous cell carcinoma or adenocarcinoma |
HPV-related dysplasia | High-risk HPV integration and cellular changes |
Chronic cervicitis / Metaplasia / Polyps | Non-malignant but potentially symptomatic lesions |
Granulomatous lesions / Tuberculosis (rare) | Infectious pathology, esp. in endemic countries like India |
🧭 Procedure Overview
- Colposcopy may guide the biopsy site.
- Local anesthesia may be applied.
- Small tissue (1–3 cm) is removed and sent for histopathological examination.
🧪 Tests Commonly Done Along With Cervical Biopsy
Test | Purpose |
|---|---|
Pap Smear / Liquid-Based Cytology | Screens for abnormal epithelial cells |
HPV DNA Typing | Identifies high-risk HPV strains |
Colposcopy | Visual inspection of the cervix using magnification |
p16/Ki67 Immunostaining | Assesses for HPV-related oncogenic transformation |
Endocervical Curettage (ECC) | Samples the endocervical canal if required |
HIV and STD Panel | Rule out concurrent infections, especially if lesions present |
📊 Histopathology Report May Include:
- Tissue architecture (normal, inflammatory, neoplastic)
- Grade of dysplasia (mild, moderate, severe)
- Presence of HPV-related changes
- Tumor type, grade, invasion (if malignant)
⚠️ What Happens After the Report?
Findings | Next Step |
|---|---|
CIN I | Observation or local ablation |
CIN II/III | LEEP or cone biopsy |
Invasive cancer | MRI/CT staging + oncologic treatment (surgery/radiation/chemo) |
📋 Summary
Test | Cervix Biopsy – Medium (1–3 cm) Tissue |
|---|---|
Purpose | Detect precancerous/cancerous changes |
Used For | HPV lesions, abnormal Pap smear, bleeding |
Reported By | Histopathologist |
Often Accompanied With | HPV test, Pap smear, colposcopy |
How our test process works!
