Hormone Panel (Female)
8 parameters
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FSH (Follicle-stimulating hormone), LH (Luteinizing hormone), Prolactin, Cortisol, DHEA sulfate, Sex hormone binding globulin (SHBG), Progesterone, Estradiol
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🧬 Hormonal Panel: Female Fertility & Endocrine Health
Hormone | Fasting Required | Sample Type | Best Time to Test | Key Organ/System |
|---|---|---|---|---|
FSH | ✅ Yes (8–10 hrs) | Blood (Serum) | Day 2–5 of menstrual cycle | Pituitary → Ovaries |
LH | ✅ Yes | Blood (Serum) | Day 2–5 or mid-cycle (ovulation tracking) | Pituitary → Ovaries |
Prolactin | ✅ Yes, early morning | Blood (Serum) | Morning, 3–4 hrs after waking | Pituitary |
Cortisol | ✅ Yes (preferably) | Blood (Serum) | 8 AM (and/or 4 PM) | Adrenal glands |
DHEA-S | ✅ Yes (morning) | Blood (Serum) | Early morning | Adrenal glands |
SHBG | ✅ Yes | Blood (Serum) | Early morning | Liver (modulates sex hormones) |
Progesterone | ✅ Yes (optional) | Blood (Serum) | Day 21 of a 28-day cycle (mid-luteal phase) | Ovaries |
Estradiol | ✅ Yes | Blood (Serum) | Day 2–5 of cycle | Ovaries |
🔍 Test-by-Test Explanation
1. FSH (Follicle-Stimulating Hormone)
- 💡 Stimulates development of ovarian follicles
- 📈 High FSH: Ovarian failure, menopause
- 📉 Low FSH: Hypopituitarism, hypothalamic dysfunction
- 🧪 Use with: LH, Estradiol, AMH
2. LH (Luteinizing Hormone)
- 💡 Triggers ovulation mid-cycle
- 📈 High LH: PCOS, premature ovarian failure
- 📉 Low LH: Pituitary issues
- 🧪 Use with: FSH, Estradiol, Progesterone
3. Prolactin
- 💡 Stimulates breast milk production
- 📈 High: Prolactinoma, hypothyroidism
- 📉 Low: Pituitary dysfunction
- 🧪 Use with: TSH, MRI (if prolactin >100 ng/mL)
4. Cortisol
- 💡 Regulates stress response, BP, glucose metabolism
- 📈 High: Cushing’s, chronic stress
- 📉 Low: Addison’s disease
- 🧪 Use with: ACTH, DHEA-S, electrolytes
5. DHEA-S (Dehydroepiandrosterone Sulfate)
- 💡 Precursor to estrogen and testosterone
- 📈 High: PCOS, adrenal tumors
- 📉 Low: Adrenal insufficiency
- 🧪 Use with: Testosterone, Cortisol, LH
6. SHBG (Sex Hormone Binding Globulin)
- 💡 Binds to estrogen and testosterone → affects free levels
- 📈 High: Hyperthyroidism, estrogen therapy
- 📉 Low: PCOS, insulin resistance
- 🧪 Use with: Total & Free Testosterone, Estradiol
7. Progesterone
- 💡 Maintains uterine lining after ovulation
- 📈 High (luteal phase): Confirms ovulation
- 📉 Low: Anovulation, luteal phase defect
- 🧪 Use with: LH, FSH, Estradiol
8. Estradiol (E2)
- 💡 Main estrogen in reproductive women
- 📈 High: Ovarian tumors, estrogen therapy
- 📉 Low: Menopause, ovarian failure
- 🧪 Use with: FSH, LH, Progesterone
🧪 Summary Table
Hormone | High Level Suggests | Low Level Suggests |
|---|---|---|
FSH | Menopause, ovarian failure | Pituitary/hypothalamic issue |
LH | PCOS, menopause | Pituitary dysfunction |
Prolactin | Prolactinoma, hypothyroid | Pituitary failure |
Cortisol | Cushing’s, stress | Addison’s disease |
DHEA-S | PCOS, adrenal tumor | Adrenal insufficiency |
SHBG | Hyperthyroid, liver disease | PCOS, obesity |
Progesterone | Ovulation occurred | Luteal phase defect |
Estradiol | Estrogen excess, tumors | Ovarian failure, menopause |
📋 Clinical Use Cases
Clinical Concern | Recommended Panel |
|---|---|
Irregular or absent periods | FSH, LH, Estradiol, Progesterone, Prolactin, TSH |
Suspected PCOS | LH, FSH, DHEA-S, Testosterone, SHBG, Estradiol |
Infertility (female) | FSH, LH, Estradiol, AMH, Progesterone, Prolactin |
Adrenal fatigue | Cortisol, DHEA-S, ACTH, Electrolytes |
Estrogen dominance/deficiency | Estradiol, Progesterone, SHBG, LH |
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