🩺 Kidney Function Profile – Detailed Breakdown
Test Name | Fasting Required? | System/Organ | What It Measures | Clinical Significance | Associated Conditions |
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1. BUN (Blood Urea Nitrogen)
- ✅ Fasting: Yes (8–10 hrs recommended)
- 🎯 System: Liver → Kidneys
- 📊 Measures: Urea nitrogen in blood, a waste from protein metabolism
- 📈 High: Kidney dysfunction, dehydration, high protein intake, GI bleed
- 📉 Low: Liver disease, malnutrition
- 🩺 Used to assess: Renal filtration & protein metabolism
2. Creatinine
- ✅ Fasting: Yes
- 🎯 System: Kidneys
- 📊 Measures: Waste from muscle metabolism, excreted by kidneys
- 📈 High: Kidney failure, obstruction, dehydration
- 📉 Low: Muscle loss, liver disease
- 🩺 Key Indicator: of kidney filtration efficiency
3. Uric Acid
- ✅ Fasting: Yes
- 🎯 System: Kidneys, joints
- 📊 Measures: Breakdown product of purines
- 📈 High: Gout, renal dysfunction, high purine diet
- 📉 Low: Liver disease, Wilson’s disease
- 🩺 Useful in: Gout diagnosis, kidney stone risk
4. BUN / Creatinine Ratio
- ❌ Fasting: Not essential if BUN & Creatinine are fasting
- 🎯 System: Kidneys
- 📊 Measures: Whether elevated BUN is due to renal or pre-renal causes
- 📈 High (>20:1): Dehydration, GI bleeding
- 📉 Low (<10:1): Liver disease, malnutrition
- 🩺 Differentiates: between types of kidney dysfunction
5. Urea
- ✅ Fasting: Yes
- 🎯 System: Liver → Kidneys
- 📊 Measures: Urea in blood, direct measure of nitrogen waste
- 📈 High: Kidney dysfunction
- 📉 Low: Liver dysfunction
- 🩺 Often reported alongside BUN
6. Calcium (Serum)
- ✅ Fasting: Yes
- 🎯 System: Kidneys, Bones, Parathyroid
- 📊 Measures: Mineral crucial for bones, nerves, and heart
- 📈 High: Parathyroid disorder, cancer, kidney failure
- 📉 Low: Vitamin D deficiency, renal disease
- 🩺 Kidneys regulate calcium-phosphate balance
7. Sodium
- ✅ Fasting: Yes
- 🎯 System: Kidneys, Nervous System
- 📊 Measures: Major electrolyte controlling fluid balance
- 📈 High (Hypernatremia): Dehydration, diabetes insipidus
- 📉 Low (Hyponatremia): SIADH, heart/kidney failure
- 🩺 Monitors: Water-electrolyte imbalance
8. Potassium
- ✅ Fasting: Yes
- 🎯 System: Kidneys, Heart
- 📊 Measures: Essential electrolyte for nerve and muscle function
- 📈 High (Hyperkalemia): Kidney failure, ACE inhibitors
- 📉 Low (Hypokalemia): Diuretics, vomiting, diarrhea
- 🩺 Critical for: Heart rhythm stability
9. Chloride
- ✅ Fasting: Yes
- 🎯 System: Kidneys, Acid-Base Balance
- 📊 Measures: Anion helping maintain acid-base and fluid balance
- 📈 High: Kidney dysfunction, dehydration
- 📉 Low: Metabolic alkalosis, vomiting
- 🩺 Interpreted with: Sodium & Bicarbonate
10. eGFR (Estimated Glomerular Filtration Rate)
- ❌ Fasting: Not mandatory
- 🎯 System: Kidneys
- 📊 Estimates: Rate at which kidneys filter blood (calculated from Creatinine, Age, Gender, Ethnicity)
- ✅ Normal eGFR: > 90 mL/min
- ⚠️ <60 mL/min: Suggests chronic kidney disease
- 🩺 Gold standard for kidney function monitoring
📋 Summary Table
Test | Function | High Levels Indicate | Low Levels Indicate |
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BUN | Nitrogen waste excretion | Kidney disease, dehydration | Liver dysfunction, malnutrition |
Creatinine | Muscle waste filtration | Kidney disease | Muscle wasting, liver disease |
Uric Acid | Purine metabolism | Gout, kidney stones | Liver disease, Wilson’s disease |
Urea | Waste from protein metabolism | Kidney overload | Liver disease |
BUN/Creat Ratio | Nature of dysfunction | Pre-renal (dehydration) | Liver issues, malnutrition |
Calcium | Bone health, neuromuscular control | Hyperparathyroidism, renal failure | CKD, vitamin D deficiency |
Sodium | Fluid and nerve balance | Dehydration | SIADH, fluid overload |
Potassium | Cardiac/muscle function | Renal failure | Diuretics, GI loss |
Chloride | Acid-base regulation | Metabolic acidosis | Vomiting, alkalosis |
eGFR | Filtration capacity | — | CKD, AKI, ESRD |
🧪 Recommended Complementary Tests
If kidney dysfunction suspected: | Test |
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Protein in urine | Urine Albumin-Creatinine Ratio (UACR) |
Liver involvement | LFT (Liver Function Test) |
Diabetes-related renal risk | HbA1c, Fasting Glucose |
Autoimmune kidney conditions | ANA, Anti-dsDNA, C3/C4, ANCA |
Chronic management | USG Abdomen (Kidneys), Serum Phosphorus |