Pancreatic Profile (2 Parameters)
2 parameters
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Amylase, Lipase
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🩸 Pancreatic Enzymes – Amylase & Lipase
Test | Fasting Required? | Organ/System | What It Measures | Why It's Important | Common Conditions Detected |
|---|
1. Amylase
- ✅ Fasting: Recommended (8–10 hours)
- 🎯 System: Pancreas, Salivary Glands
- 📊 Measures: Enzyme that helps digest carbohydrates by breaking down starch into sugars
- 📈 High Levels:
- Acute pancreatitis (usually 3–5× normal)
- Pancreatic duct obstruction
- Mumps (salivary gland inflammation)
- Perforated ulcer, ectopic pregnancy (non-pancreatic causes)
- 📉 Low Levels:
- Chronic pancreatitis (damaged enzyme-producing cells)
- Pancreatic insufficiency
- 🩺 Time to Rise: Rises within 6–12 hours of pancreatic inflammation; normalizes within 3–4 days
2. Lipase
- ✅ Fasting: Yes
- 🎯 System: Pancreas
- 📊 Measures: Enzyme that helps digest dietary fats
- 📈 High Levels:
- Acute pancreatitis (more specific and stays elevated longer than amylase)
- Pancreatic tumors or duct obstruction
- Renal failure (reduced clearance)
- 📉 Low Levels:
- Pancreatic insufficiency
- Cystic fibrosis (long-standing cases)
- 🩺 Time to Rise: Rises within 4–8 hours of pancreatic injury, peaks at 24 hours, stays elevated for 8–14 days
- 🧪 More specific than amylase for pancreas-related pathology
🧪 Amylase vs Lipase – Quick Comparison
Feature | Amylase | Lipase |
|---|---|---|
Main Role | Carbohydrate digestion | Fat digestion |
Source | Pancreas & Salivary Glands | Pancreas only (mostly) |
Rises When? | 6–12 hours after injury | 4–8 hours after injury |
Stays Elevated? | 3–4 days | Up to 14 days |
Specificity to Pancreas | Moderate | High (preferred marker) |
Utility | Early pancreatitis, non-pancreatic causes | Acute & chronic pancreatic disease |
🔬 When Are These Tests Ordered?
These tests are ordered when a patient presents with:
- Sudden abdominal pain (especially upper abdomen radiating to the back)
- Nausea/vomiting
- Fever and signs of acute pancreatitis
- Chronic digestive issues, fat malabsorption, or pancreatic cancer suspicion
📎 Recommended Conjunctive Tests
Scenario | Additional Tests |
|---|---|
Suspected acute pancreatitis | CBC, CRP, Liver Function Test, Abdominal Ultrasound |
Chronic pancreatic disease | Fecal elastase, Glucose, CT abdomen |
Obstructive jaundice | Bilirubin (direct/indirect), ALP, GGT |
Rule out salivary issues (if amylase ↑) | Salivary gland imaging (sialography) |
How our test process works!
