PR3 - ANCA ( C-ANCA )
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Associated with a Cytoplasmic (C-ANCA) staining pattern on immunofluorescence
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🧪 What is PR3-ANCA (C-ANCA)?
PR3-ANCA refers to Anti-Proteinase 3 Anti-Neutrophil Cytoplasmic Antibodies, typically associated with a Cytoplasmic (C-ANCA) staining pattern on immunofluorescence.
- It is an autoantibody targeting proteinase 3, an enzyme found in neutrophil granules.
- PR3-ANCA is strongly linked with Granulomatosis with Polyangiitis (GPA), formerly called Wegener’s granulomatosis.
❓ Why is the Test Done?
To:
- Diagnose Granulomatosis with Polyangiitis (GPA)
- Differentiate types of ANCA-associated vasculitis (AAV)
- Monitor disease activity and response to treatment
- Evaluate patients with symptoms like sinusitis, pulmonary nodules, glomerulonephritis
📊 Normal Range
Result | Interpretation |
|---|---|
Negative | No detectable PR3-ANCA antibodies |
Positive | Presence of PR3-ANCA antibodies, levels vary by lab |
The lab-specific cutoff values determine positivity; often ELISA units >20 U/mL indicate positive.
📈 Interpretation of Results
PR3-ANCA Status | Clinical Implication |
|---|---|
Positive | Highly suggestive of Granulomatosis with Polyangiitis |
Negative | Does not exclude vasculitis but lowers probability |
Low-positive/Weak | May occur in other autoimmune diseases or infections |
🧠 Associated Organs & Conditions
Organ/System | Conditions Associated |
|---|---|
Respiratory | Upper and lower airway granulomas, sinusitis, lung nodules |
Renal | Pauci-immune crescentic glomerulonephritis |
ENT | Nasal ulcers, otitis media |
Others | Skin lesions, peripheral neuropathy |
🔄 Related / Follow-Up Tests
- MPO-ANCA (P-ANCA) – helps differentiate vasculitis types
- ANA, RF – autoimmune screening
- Urinalysis – hematuria/proteinuria in renal involvement
- Kidney biopsy – confirms pauci-immune vasculitis
- Chest imaging – assess pulmonary involvement
✅ Fasting Required?
Test | Fasting Required |
|---|---|
PR3-ANCA | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Detects autoantibodies against proteinase 3 in neutrophils |
Why | Diagnose and monitor Granulomatosis with Polyangiitis |
Normal Range | Negative |
Positive Result | Suggestive of GPA (Wegener’s granulomatosis) |
Associated Conditions | GPA, systemic vasculitis |
Follow-up Tests | MPO-ANCA, ANA, urinalysis, biopsy, imaging |
Fasting Required | ❌ No |
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