TORCH Advanced Panel
13 parameters
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Cytomegalo Virus (CMV) IgG, Cytomegalo Virus (CMV) IgM, Herpes Simplex Virus (HCV) I IgG, Herpes Simplex Virus (HCV) I IgM, Herpes Simplex Virus (HCV) II IgG, Herpes Simplex Virus (HCV) II IgM, Rubella IgG, Rubella IgM, Toxoplasma Gondii IgG, Toxoplasma Gondii IgM, Syphilis TP, Varicella Zooster IgG, Varicella Zooster IgM
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🧪 Infectious Screening Panel (IgG, IgM, and Other Serologies)
# | Test Name | What it Detects | IgG Interpretation | IgM Interpretation | Fasting Required |
|---|---|---|---|---|---|
1 | CMV IgG | Past Cytomegalovirus exposure | ✅ Past infection/immunity | ❌ Not applicable | ❌ |
2 | CMV IgM | Recent Cytomegalovirus infection | ❌ | ✅ Recent/active infection, concerning in pregnancy | ❌ |
3 | HSV I IgG | Past Herpes Simplex Virus 1 infection | ✅ Past exposure (oral herpes) | ❌ | ❌ |
4 | HSV I IgM | Acute/reactivated HSV-1 | ❌ | ✅ Current or recent infection | ❌ |
5 | HSV II IgG | Past Herpes Simplex Virus 2 infection | ✅ Past exposure (genital herpes) | ❌ | ❌ |
6 | HSV II IgM | Acute/reactivated HSV-2 | ❌ | ✅ Current infection or reactivation | ❌ |
7 | Rubella IgG | Immunity to Rubella | ✅ Immune (post-infection/vaccine) | ❌ | ❌ |
8 | Rubella IgM | Acute Rubella | ❌ | ✅ Recent infection; high fetal risk | ❌ |
9 | Toxoplasma IgG | Past Toxoplasma gondii infection | ✅ Immunity | ❌ | ❌ |
10 | Toxoplasma IgM | Acute Toxoplasmosis | ❌ | ✅ Recent infection; fetal risk | ❌ |
11 | Syphilis TP (Treponema pallidum) | Syphilis antibodies (lifetime) | ✅ Past or current syphilis | - | ❌ |
12 | Varicella Zoster IgG | Immunity to Chickenpox | ✅ Past infection/vaccine | ❌ | ❌ |
13 | Varicella Zoster IgM | Acute Chickenpox or Reactivation (shingles) | ❌ | ✅ Active or recent infection | ❌ |
📊 Summary of Key Clinical Interpretations
✅ IgG Positive (IgM Negative)
- Interpretation: Past exposure or vaccination. Typically indicates immunity.
- Clinical Action: No further intervention needed unless symptoms present.
⚠️ IgM Positive (with or without IgG)
- Interpretation: Current or recent infection — can be harmful during pregnancy or for immunocompromised individuals.
- Clinical Action: Confirm with PCR/avidity testing and manage based on stage and severity.
🧠 High-Risk Implications in Pregnancy
Infection | Risk to Fetus |
|---|---|
CMV (IgM) | Hearing loss, mental retardation, IUGR |
Rubella (IgM) | Congenital rubella syndrome – cardiac defects, cataracts, deafness |
Toxoplasma (IgM) | Brain calcifications, hydrocephalus, chorioretinitis |
Syphilis (TP) | Stillbirth, deformities, hydrops fetalis |
HSV II (IgM) | Neonatal herpes (life-threatening if active during delivery) |
Varicella (IgM) | Congenital varicella syndrome if infection in first 20 weeks |
🔄 Suggested Related / Follow-up Tests
- PCR Tests for: CMV, HSV, Rubella, Toxoplasma
- IgG Avidity Testing (to determine recent vs past infection)
- Ultrasound Monitoring (in pregnancy)
- Fetal TORCH Screening (when needed)
- FTA-ABS / VDRL for syphilis confirmation
- Liver, Kidney Panels if systemic symptoms are present
📝 Recap Table
Parameter | Value |
|---|---|
Panel Includes | CMV, HSV I & II, Rubella, Toxoplasma, Syphilis, Varicella |
Markers Measured | IgG (Immunity), IgM (Recent/Acute) |
Critical for Pregnancy | Rubella IgM, CMV IgM, Toxoplasma IgM, HSV II IgM |
Fasting Required | ❌ No |
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