Vitamin D1,25 Dihydroxy
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Assesses 25-hydroxyvitamin D levels to determine deficiency, affecting bone strength and immune function.
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🧪 What is Vitamin D1,25 Dihydroxy?
Vitamin D1,25 Dihydroxy, also called Calcitriol, is the biologically active form of Vitamin D. It is produced by the hydroxylation of 25-hydroxyvitamin D (calcidiol) in the kidneys. Calcitriol regulates calcium and phosphate metabolism and promotes bone health.
❓ Why is the Test Done?
To:
- Evaluate disorders of calcium metabolism
- Diagnose and monitor conditions such as renal failure, hypoparathyroidism, osteomalacia, and vitamin D-dependent rickets
- Assess hypercalcemia causes, including granulomatous diseases (e.g., sarcoidosis) and some lymphomas
- Monitor treatment with calcitriol supplementation
📊 Normal Range
Vitamin D1,25 Dihydroxy Level | Reference Range |
|---|---|
18 – 72 pg/mL (45 – 180 pmol/L) | May vary by laboratory |
📈 Interpretation of Results
Level | Clinical Significance |
|---|---|
Low levels | Vitamin D deficiency, renal failure, hypoparathyroidism |
Normal levels | Adequate active vitamin D |
High levels | Granulomatous diseases, lymphomas, vitamin D intoxication |
🧠 Associated Conditions
Condition | Details |
|---|---|
Chronic kidney disease | Impaired calcitriol synthesis |
Hypoparathyroidism | Reduced stimulation of calcitriol production |
Sarcoidosis and granulomatous diseases | Increased extrarenal production leading to hypercalcemia |
Vitamin D toxicity | Excessive intake causing elevated calcitriol |
🔄 Related / Follow-Up Tests
- Serum 25-hydroxyvitamin D (calcidiol) – reflects vitamin D stores
- Serum calcium and phosphate
- Parathyroid hormone (PTH)
- Renal function tests
✅ Fasting Required?
Test | Fasting Required |
|---|---|
Vitamin D1,25 Dihydroxy | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures biologically active vitamin D (calcitriol) |
Why | Evaluate calcium metabolism disorders |
Normal Range | 18–72 pg/mL |
Low Levels | Deficiency states, renal failure, hypoparathyroidism |
High Levels | Granulomatous disease, lymphoma, vitamin D toxicity |
Associated Conditions | CKD, sarcoidosis, hypoparathyroidism |
Follow-up Tests | 25-hydroxyvitamin D, calcium, PTH, renal tests |
Fasting Required | ❌ No |
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