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Advanced Fever Profile

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34 parameters

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Complete Hemogram (28), Dengue -IgG (ELISA), Dengue - IgM (ELISA), Typhi Dot IgG & IgM, SARS-COV-2 Spike protein IgG Antibodies, Leptospira IgM, Dengue NS1, Malarial Antigen Detection, Smear for MP (Malarial Parasite), Chikungunya Combo Rapid Test

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Test Overview

  • Dengue IgG (ELISA)
    • Purpose: Detects IgG antibodies to dengue virus
    • Timing: Appears 7–10 days after infection, and may remain for life
    • Interpretation:
      • Positive IgG + Negative IgM: Past dengue infection
      • Positive IgG + Positive IgM: Current or recent secondary dengue infection
    • Why it matters: Helps differentiate primary vs secondary infection (secondary infections are often more severe)
  • Dengue IgM (ELISA)
    • Purpose: Detects IgM antibodies, which are the first to appear after infection
    • Timing: Appears by Day 3–5, peaks around Day 6–10
    • Interpretation:
      • Positive IgM = Recent or current dengue infection
      • Often combined with NS1 Antigen for early detection
    • Why it matters: IgM confirms active or recent dengue, helpful in early diagnosis and outbreak monitoring
  • Leptospira IgM
    • Purpose: Detects IgM antibodies to Leptospira bacteria
    • Timing: Detectable by Day 5–7 after exposure to contaminated water/soil
    • Interpretation:
      • Positive = Leptospirosis (common in monsoon/flood-prone areas)
    • Symptoms Mimicked: Fever, headache, jaundice, body pain (often confused with dengue or viral fevers)
  • Malarial Antigen Detection
    • Purpose: Rapidly detects antigens of Plasmodium species (e.g., P. falciparum, P. vivax)
    • Speed: Provides results in 15–30 minutes
    • Why it’s used:
      • Useful in emergency diagnosis
      • More sensitive than smear in early stages
    • Interpretation:
      • Positive = Active malaria infection
      • Species identification helps guide treatment
  • Chikungunya Combo Rapid Test (IgM + IgG)
    • Purpose: Detects both IgM and IgG antibodies for Chikungunya virus
    • IgM = Recent or current infection
    • IgG = Past infection
    • Symptoms: High fever, joint pain, rash – often overlaps with dengue
    • Why it’s helpful: Rapid diagnosis helps distinguish chikungunya from dengue or Zika
  • Typhi Dot IgG & IgM
    • Purpose: Detects IgM and IgG antibodies against Salmonella typhi (cause of typhoid fever)
    • Timing:
      • IgM – Appears early (Day 4–6); indicates acute infection
      • IgG – Appears later; indicates past infection or carrier state
    • Interpretation:
      • IgM Positive = Active typhoid fever
      • IgG Positive = Previous exposure or vaccination
    • Note: Often used as a rapid alternative to blood culture (gold standard)
  • CBC – Complete Haemogram (28 Parameters)
    • Purpose: Provides a snapshot of blood health during infections
    • In fever cases, key values to note:
      • Platelets – Often low in dengue, malaria, leptospirosis
      • WBC Count – Low in viral infections (e.g., dengue), high in bacterial ones (e.g., typhoid)
      • Hemoglobin & RBCs – Check for anemia or hemoconcentration
      • oDifferential Count (Neutrophils, Lymphocytes) – Helps determine viral vs bacterial origin
    • Why it matters: Helps monitor disease severity, progression, and complications like dengue hemorrhagic fever

Summary Use Case

ConditionKey Tests to PrioritizeNotes
DengueNS1, IgM, IgG, CBCLow platelets + IgM/NS1 = acute; IgG = past infection
MalariaMalarial Antigen + CBCRule out rapidly in high fever + chills; Plasmodium species key
LeptospirosisLeptospira IgM + LFTConsider in monsoon fever with muscle/joint pain and jaundice
ChikungunyaIgM/IgG Rapid TestJoint pain dominates; often with rash
TyphoidTyphi Dot IgM/IgG + CBCHigh WBCs, prolonged fever; may show mild liver enzyme elevation

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