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Advanced - Fever Profile

Bacterial/ Viral

36 parameters

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Report in 12Hrs

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nofastingrequire

No Fasting Required

Details

Panel for fever causes (malaria, dengue, typhoid).

₹1,499₹2,199

32% OFF

Parameters

  • List of Tests
    • Dengue - IgG (ELISA)
    • Dengue - IgM (ELISA)
    • Leptospira IgM
    • Malarial Antigen Detection
    • Chikungunya IgM, IgG
    • Thyphi Dot IgM, IgG
    • CBC - Complete Hemogram (28)

Advanced - Fever Profile

  • Why is it done?
    • This comprehensive fever profile is designed to identify the underlying infectious cause of fever through serological detection and hematological assessment
    • Dengue IgG and IgM detect dengue virus exposure - IgM indicates acute/recent infection while IgG suggests past immunity or chronic infection
    • Leptospira IgM identifies acute leptospirosis, a spirochetal infection transmitted through contaminated water and animal urine
    • Malarial Antigen Detection directly identifies Plasmodium parasites in blood to confirm malaria diagnosis
    • Chikungunya IgM and IgG detect chikungunya virus antibodies for acute and past infections
    • Thyphi Dot IgM and IgG detect Salmonella typhi antibodies to confirm typhoid fever diagnosis
    • CBC provides comprehensive hematological assessment to identify anemia, leukocytosis, thrombocytopenia, and other blood abnormalities associated with infectious diseases
    • Indicated for patients presenting with unexplained fever, particularly in endemic regions or during seasonal outbreaks of vector-borne diseases
    • Recommended for fever of unknown origin (FUO) lasting more than 7-10 days to systematically exclude common tropical and endemic infectious diseases
    • Useful in differential diagnosis of febrile illnesses with similar presentations, particularly in tropical and subtropical regions
  • Normal Range
    • Dengue IgG (ELISA): Negative or <1.0 index value indicates absence of dengue IgG antibodies; positive or ≥1.0 indicates prior dengue exposure or immunity
    • Dengue IgM (ELISA): Negative or <0.9 index value is normal; positive or ≥0.9 suggests acute or recent dengue infection
    • Leptospira IgM: Negative or <1.0 index value is normal; positive or ≥1.0 indicates acute leptospiral infection within first 5-7 days of illness
    • Malarial Antigen Detection: Negative (no parasites detected) is normal; positive indicates presence of Plasmodium parasites
    • Chikungunya IgM: Negative or <0.9 index value is normal; positive or ≥0.9 indicates acute chikungunya infection
    • Chikungunya IgG: Negative or <1.0 index value indicates no past exposure; positive or ≥1.0 suggests past chikungunya infection or immunity
    • Thyphi Dot IgM: Negative is normal; positive indicates acute typhoid fever infection
    • Thyphi Dot IgG: Negative is normal; positive may indicate past typhoid infection, recovery, or vaccination
    • CBC - Complete Hemogram (28 parameters): Hemoglobin 13.5-17.5 g/dL (males), 12.0-15.5 g/dL (females); WBC 4,500-11,000/μL; Platelets 150,000-400,000/μL; RBC 4.5-5.9 million/μL (males), 4.1-5.1 million/μL (females)
    • CBC - Hematocrit: 40.7-50.3% (males), 36.1-44.3% (females); MCV 80-100 fL; MCH 27-33 pg; MCHC 32-36 g/dL
    • CBC - Differential WBC: Neutrophils 50-70%, Lymphocytes 20-40%, Monocytes 2-8%, Eosinophils 1-4%, Basophils 0-1%
  • Interpretation
    • Dengue IgM Positive: Indicates acute dengue infection or very recent exposure; most specific for primary infection in first 5 days; cross-reactivity possible with other flaviviruses
    • Dengue IgG Positive with IgM Negative: Suggests past dengue infection or chronic exposure; provides no evidence of current acute infection
    • Both Dengue IgM and IgG Positive: Indicates secondary dengue infection or re-infection; higher risk for dengue hemorrhagic fever/dengue shock syndrome
    • Leptospira IgM Positive: Indicates acute leptospirosis; typically appears after 5-7 days of illness; peaked during second week; negative results do not exclude infection in first week
    • Malarial Antigen Positive: Confirms active malaria parasitemia; identifies presence of Plasmodium species; specimen type may limit species differentiation
    • Malarial Antigen Negative with Clinical Suspicion: May represent low parasitemia; false negatives occur early in infection or with certain Plasmodium species; repeat testing recommended
    • Chikungunya IgM Positive: Indicates acute or recent chikungunya infection; appears within 3-8 days of symptom onset; remains positive for several months
    • Chikungunya IgG Positive: Indicates past infection or chronic immunity; may persist for years; useful for epidemiological studies and exposure history
    • Thyphi Dot IgM Positive: Indicates acute typhoid fever infection; appears during first week to ten days of illness; highly specific for active infection
    • Thyphi Dot IgG Positive: Indicates past typhoid infection, recovery, or vaccination; does not necessarily indicate current acute infection
    • Both Thyphi IgM and IgG Positive: Indicates acute typhoid fever with convalescent response; suggests ongoing or recently acquired infection
    • CBC - Elevated WBC (>11,000/μL): Suggests bacterial or acute viral infection; neutrophilia indicates bacterial infection; lymphocytosis seen with viral infections
    • CBC - Decreased WBC (<4,500/μL): May indicate viral infection, dengue hemorrhagic fever, typhoid in later stages, or bone marrow suppression
    • CBC - Thrombocytopenia (<150,000/μL): Particularly significant in dengue, chikungunya, and leptospirosis; severe thrombocytopenia (<50,000/μL) indicates increased bleeding risk
    • CBC - Anemia (Low Hemoglobin/Hematocrit): May result from chronic infection, malaria with hemolysis, or hemorrhagic complications
    • Factors Affecting Results: Timing of blood draw relative to illness onset significantly affects antibody detection; early in disease (first 5 days) IgM may be negative; specimen quality and storage affect accuracy
    • Cross-reactivity: Dengue serology may cross-react with other flaviviruses (Zika, Yellow Fever); Leptospira detection may have false positives from other spirochetal infections
  • Associated Organs
    • Dengue: Affects liver (hepatitis, liver necrosis), blood vessels (vascular leakage), heart (myocarditis), kidneys (acute kidney injury in severe cases), and hematologic system (thrombocytopenia, DIC)
    • Dengue Complications: Dengue hemorrhagic fever, dengue shock syndrome, severe hepatic impairment, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation
    • Leptospirosis: Affects liver (hepatitis, jaundice), kidneys (renal failure, acute tubular necrosis), lungs (pulmonary hemorrhage), heart (myocarditis), and meninges (aseptic meningitis)
    • Leptospirosis Complications: Weil's disease (severe leptospirosis with jaundice, renal failure, hemorrhage), pulmonary hemorrhage, renal dysfunction, myocarditis, meningitis
    • Malaria: Affects blood (parasitemia, hemolysis), liver (hepatic dysfunction, portal hypertension), brain (cerebral malaria), kidneys (acute kidney injury), lungs (acute respiratory distress)
    • Malaria Complications: Severe anemia, cerebral malaria, acute renal failure, pulmonary edema, metabolic acidosis, hypoglycemia, hepatic dysfunction
    • Chikungunya: Affects joints (arthralgia, arthritis), muscles (myalgia), skin (rash), and nervous system (neuro-invasion in severe cases); typically less severe organ involvement than dengue
    • Chikungunya Complications: Persistent arthralgia (chronic joint pain), myositis, encephalitis (rare), cardiac involvement, hemorrhagic manifestations in severe cases
    • Typhoid Fever: Affects liver (hepatitis, focal abscess), intestines (perforation), heart (myocarditis), brain (encephalopathy), and hematologic system
    • Typhoid Complications: Intestinal perforation, toxic myocarditis, encephalopathy, hepatic dysfunction, disseminated intravascular coagulation, septic shock
    • CBC - Evaluates bone marrow function, immune response, and overall hematologic integrity; reflects systemic effects of infection on blood-forming organs
    • CBC Abnormalities: Reflect organ system involvement in infectious diseases; thrombocytopenia and anemia indicate severity and complications; WBC pattern helps differentiate viral vs bacterial etiology
  • Follow-up Tests
    • If Dengue IgM Positive: Dengue PCR/RT-PCR for viral confirmation, Dengue NS1 antigen test for early detection, Viral load quantification for prognostic assessment, serial CBC monitoring every 2-3 days
    • If Dengue Suspected: Liver Function Tests (AST, ALT, bilirubin), Coagulation profile (PT, INR, aPTT), Platelet count monitoring, Plasma leakage assessment if DHF/DSS suspected
    • If Leptospira IgM Positive: Leptospira culture (early phase), Leptospira PCR, MAT (Microscopic Agglutination Test) for confirmation, Kidney Function Tests (creatinine, BUN, urinalysis)
    • If Leptospirosis Suspected: Liver Function Tests, Coagulation profile, Urinalysis with microscopy, Repeat IgM testing after 5-7 days if initial testing done early
    • If Malarial Antigen Positive: Species identification via blood smear microscopy or PCR, Parasite density assessment, Glucose level testing, Renal function tests, Hemoglobin electrophoresis if needed
    • If Malaria Suspected: Repeated malaria antigen testing at 12-24 hour intervals if negative with high clinical suspicion, Thick and thin blood smears, Lactate level assessment, Follow-up CBC post-treatment
    • If Chikungunya IgM Positive: Chikungunya RT-PCR for viral confirmation, Joint imaging if chronic arthralgia develops, Follow-up IgG at 2-4 weeks for seroconversion confirmation
    • If Chikungunya Suspected: Inflammatory markers (ESR, CRP), Rheumatological assessment for persistent arthralgia, Cardiac evaluation if myocarditis suspected
    • If Thyphi IgM Positive: Blood culture for organism isolation and antimicrobial susceptibility, Urine culture (organisms may be found in urine), Stool culture (persistent shedding), Widal test for confirmation
    • If Typhoid Fever Suspected: Abdominal imaging (ultrasound/CT) for complications, Liver Function Tests, Coagulation profile, Repeat blood cultures if treatment response suboptimal
    • General Follow-up Recommendations: Repeat fever profile testing after 5-7 days if initial tests negative but clinical suspicion remains high; serial CBC at 2-3 day intervals to monitor disease progression
    • For Mixed or Co-infections: Multiple pathogens may co-exist; positive results for multiple organisms require careful clinical correlation; management intensity increases with multiple infections
    • Convalescent Phase Testing: For negative acute serology, repeat testing after 10-14 days may show IgG seroconversion; paired sera (acute and convalescent) can confirm infections
  • Fasting Required?
    • Fasting Required: NO - This fever profile does not require fasting; blood samples can be collected at any time of day regardless of meal intake
    • Serological Tests (Dengue, Leptospira, Chikungunya, Thyphi): All ELISA and immunochromatographic tests are unaffected by food intake or fasting status
    • Malarial Antigen Detection: Does not require fasting; can be performed at any time; parasites can be detected on blood samples irrespective of meal timing
    • CBC - Complete Hemogram: Does not require fasting; hematological parameters are not affected by food intake
    • Patient Preparation: Patient may eat and drink normally; no dietary restrictions required; no medications need to be stopped specifically for this test panel
    • Optimal Timing: For best results, blood samples should be collected during or shortly after fever episodes; timing relative to illness onset is more critical than fasting status
    • Sample Collection: 3-5 mL of venous blood in EDTA tube for CBC; 5 mL of venous blood in serum separator tube for serological tests; samples should not be hemolyzed
    • Sample Handling: Maintain room temperature until separation; CBC samples should be analyzed within 4-6 hours; serum samples should be refrigerated at 2-8°C if processing delayed
    • Medications: No specific medications need to be discontinued; antibiotic therapy does not invalidate serological tests; immunosuppressive therapy may affect antibody response
    • Physical Activity: No restriction on physical activity before blood draw; patient may engage in normal daily activities

How our test process works!

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