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Allergy panel-others Adult (Comprehensive) Panel parameters

Allergy
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Report in 48Hrs

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At Home

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No Fasting Required

Details

Broad IgE panel including food + inhalant + environmental allergens.

₹22,200₹31,714

30% OFF

Allergy Panel-Others Adult (Comprehensive) Panel Parameters

  • Why is it done?
    • Identifies specific IgE antibodies to various allergens including dust mites, pet dander, molds, pollens, food proteins, and occupational allergens
    • Diagnoses IgE-mediated allergic reactions and hypersensitivity responses
    • Evaluates patients presenting with allergic symptoms such as rhinitis, asthma, dermatitis, gastrointestinal symptoms, or anaphylaxis
    • Determines triggers for allergic conditions when history is unclear or multiple allergens are suspected
    • Guides allergen avoidance and immunotherapy decisions
    • Assists in occupational health screening for workplace-related allergen exposure
    • Performed when skin testing is contraindicated or inconclusive
  • Normal Range
    • Normal/Negative Result: <0.35 kIU/L (kilointernational units per liter) for each specific allergen
    • Borderline: 0.35-0.70 kIU/L - may indicate minimal sensitization or clinical insignificance
    • Positive (Class 1): 0.70-3.50 kIU/L - low to moderate allergen-specific IgE
    • Positive (Class 2): 3.50-17.5 kIU/L - moderate allergen-specific IgE
    • Positive (Class 3): 17.5-52.5 kIU/L - high allergen-specific IgE
    • Positive (Class 4): 52.5-100 kIU/L - very high allergen-specific IgE
    • Positive (Class 5): >100 kIU/L - extremely high allergen-specific IgE levels
    • Unit of Measurement: kIU/L (kilointernational units per liter), also reported as IU/mL
  • Interpretation
    • Negative Results (<0.35 kIU/L): Indicates no significant IgE-mediated sensitization to tested allergen; unlikely to cause IgE-mediated allergic reaction; does not exclude other immune mechanisms (IgG, cell-mediated immunity)
    • Borderline Results (0.35-0.70 kIU/L): Equivocal; may not be clinically significant; clinical correlation required; consider repeat testing if suspicion remains high; symptoms may suggest non-IgE mechanisms
    • Class 1 Positive (0.70-3.50 kIU/L): Mild sensitization; clinically relevant if symptoms correlate; may cause minor allergic symptoms; low risk for severe reactions
    • Class 2-3 Positive (3.50-52.5 kIU/L): Moderate to high sensitization; clinically significant allergic response likely; increased risk of allergic symptoms; allergen avoidance strongly recommended
    • Class 4-5 Positive (>52.5 kIU/L): Very high sensitization; strong likelihood of allergic reactions; high risk for severe manifestations including anaphylaxis; strict allergen avoidance essential; may qualify for immunotherapy
    • Factors Affecting Results:
    • Prior antihistamine use may suppress skin testing but does not affect serum IgE
    • Medications: immunosuppressants, corticosteroids, beta-blockers may affect results
    • Atopic individuals with elevated total IgE may show higher allergen-specific IgE
    • Recent allergen exposure may transiently elevate specific IgE levels
    • Clinical history and timing of symptom onset critical for interpretation
    • Age-related factors may influence IgE production and sensitization patterns
  • Associated Organs
    • Primary Organ Systems Involved:
    • Immune system - B cells produce IgE, mast cells and basophils store and release mediators
    • Respiratory system - lungs, airways affected in asthma and rhinitis
    • Integumentary system - skin affected in urticaria, atopic dermatitis, contact dermatitis
    • Gastrointestinal system - involved in food allergies and oral allergy syndrome
    • Associated Medical Conditions:
    • Allergic rhinitis (hay fever) - elevated specific IgE to pollens, dust mites, pet dander
    • Asthma - allergic component with positive test results
    • Food allergies - IgE to specific food proteins (peanuts, shellfish, milk, eggs, tree nuts)
    • Atopic dermatitis - often associated with elevated IgE sensitization
    • Urticaria and angioedema - acute reaction to specific allergens
    • Occupational allergies - exposure to workplace allergens (latex, chemical additives)
    • Anaphylaxis - elevated specific IgE associated with risk of severe reactions
    • Potential Complications of Unmanaged Allergic Conditions:
    • Anaphylactic shock - life-threatening reaction requiring immediate epinephrine
    • Severe asthma exacerbations with respiratory compromise
    • Secondary infections from scratching allergic skin lesions
    • Chronic sinusitis from untreated allergic rhinitis
  • Follow-up Tests
    • Additional Recommended Tests Based on Positive Results:
    • Total IgE level - assess overall atopic status and immunoglobulin production
    • Component-resolved diagnostics (CRD) - identifies specific protein components causing allergic reactions
    • Skin prick test - confirmatory testing when indicated, functional assessment of allergic reactivity
    • Intradermal skin testing - for suspected occupational or drug allergies
    • Oral food challenge test - gold standard for food allergy confirmation when specific IgE inconclusive
    • Basophil activation test (BAT) - functional assay for allergen reactivity and response prediction
    • Pulmonary function tests (spirometry) - if respiratory symptoms present
    • Tryptase level - assess mast cell degranulation, particularly after suspected anaphylaxis
    • IgG testing - for delayed hypersensitivity reactions and non-IgE mediated allergies
    • Monitoring and Follow-up Frequency:
    • Annually - for stable allergic conditions on consistent allergen avoidance or immunotherapy
    • Every 3-6 months - for patients undergoing allergen immunotherapy (SCIT/SLIT) to assess desensitization
    • After significant symptom changes - if symptoms worsen or new allergens suspected
    • Post-anaphylaxis - assess severity and consider repeat testing during/after epinephrine use
    • Complementary Tests for Comprehensive Assessment:
    • Serum tryptase - marker of mast cell activation
    • Eosinophil count - elevated in allergic/parasitic conditions
    • Complete blood count - assess for anemia or infection
    • Immunoglobulin panel - evaluate immune function comprehensively
  • Fasting Required?
    • Fasting: NO - Fasting is not required for this test
    • Blood Sample Requirements:
    • Standard venipuncture using serum separator tube (SST) or EDTA tube
    • Typically 5-10 mL of blood collected
    • Allow blood to clot at room temperature for 30 minutes before centrifugation
    • Separate serum and refrigerate at 2-8°C if delayed processing
    • Medications to Avoid/Considerations:
    • Antihistamines (H1/H2 blockers) - do NOT need to be discontinued; serum IgE not affected
    • Corticosteroids - minimal effect on specific IgE but may reduce overall inflammation
    • Beta-blockers - may interfere with response to epinephrine if anaphylaxis occurs; inform healthcare provider
    • Immunosuppressants - may reduce IgE production but do not discontinue without medical guidance
    • Patient Preparation Instructions:
    • No special dietary restrictions - patient may eat and drink normally
    • Wear comfortable, loose-fitting clothing for venipuncture access
    • Remain hydrated - adequate hydration improves venipuncture success
    • Inform phlebotomist of any history of vasovagal response or difficult veins
    • Report all current medications to healthcare provider before testing
    • Bring allergy history and symptom documentation to appointment
    • No activity restrictions following blood draw

How our test process works!

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