Aluminium Serum

Kidney

Report in 96Hrs

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No Fasting Required

Details

Measures aluminium concentration in blood.

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Aluminium Serum Test Information Guide

Why is it done?
- Measures the concentration of aluminium in blood serum to assess aluminium accumulation and toxicity in the body
- Monitors patients with chronic kidney disease or those undergoing hemodialysis, as aluminium accumulates when renal clearance is impaired
- Assesses for aluminium-related bone disease and neurotoxicity complications
- Evaluates occupational or environmental aluminium exposure in at-risk workers
- Investigates symptoms of aluminium toxicity such as bone pain, weakness, or neurological changes
- Typically performed routinely in patients on long-term dialysis and when clinical symptoms suggest aluminium toxicity
Normal Range
- Normal Reference Range: 0-10 mcg/L (micrograms per liter) or 0-0.37 mcmol/L (micromoles per liter)
- Units of Measurement: mcg/L (micrograms per liter) or mcmol/L (micromoles per liter)
- Borderline Elevated: 10-20 mcg/L - may warrant monitoring and investigation
- Elevated: >20 mcg/L - indicative of aluminium accumulation and potential toxicity
- Interpretation: Normal results indicate adequate aluminium clearance and no significant accumulation. Elevated levels suggest impaired elimination, increased exposure, or potential aluminium toxicity requiring further investigation and intervention.
Interpretation
- Normal Results (0-10 mcg/L): Indicates normal aluminium levels with adequate renal clearance; no clinical concern for aluminium toxicity
- Slightly Elevated (10-20 mcg/L): Suggests mild aluminium accumulation; warrants increased monitoring and dietary restrictions; may indicate early stages of impaired clearance
- Moderately Elevated (20-50 mcg/L): Indicates significant aluminium accumulation with potential risk of toxicity; requires investigation of exposure sources and management of underlying renal disease
- Highly Elevated (>50 mcg/L): Indicates substantial aluminium toxicity with high risk of aluminium-related bone disease, neurological complications, and microcytic anaemia; urgent intervention needed
- Factors Affecting Results: Degree of renal function, dialysis efficiency, use of aluminium-containing medications (phosphate binders, antacids), occupational exposure, tap water content used in dialysate, dietary aluminium intake, and duration of chronic kidney disease
- Clinical Significance: Elevated aluminium levels are critical markers of potential organ toxicity, particularly affecting bone metabolism (causing osteodystrophy), neurological function (causing dementia and encephalopathy), and hematopoiesis (microcytic anaemia); serial measurements help track accumulation trends
Associated Organs
- Primary Organ Systems: Kidneys (primary route of aluminium elimination), bones (target organ for toxicity), brain and nervous system (neurological complications), and blood-forming tissues (bone marrow)
- Associated Conditions and Complications:
  - Chronic kidney disease (CKD) and end-stage renal disease (ESRD)
  - Aluminium-related bone disease (adynamic bone disease, osteodystrophy)
  - Dialysis encephalopathy syndrome (progressive neurological deterioration)
  - Microcytic anaemia (impaired erythropoiesis)
  - Dementia and cognitive impairment
  - Occupational aluminium exposure-related pulmonary and neurological disease
  - Secondary hyperparathyroidism complications
- Potential Complications from Elevated Levels: Bone pain and fractures, seizures and encephalopathy, progressive cognitive decline, muscle weakness, growth retardation in children, impaired immune function, and increased cardiovascular mortality risk in dialysis patients
Follow-up Tests
- Based on Elevated Results:
  - Repeat serum aluminium measurement (within 2-4 weeks) to confirm elevation and track trends
  - Deferoxamine challenge test (DFO test) to assess body aluminium burden and predict risk of aluminium-related bone disease
  - Bone markers (alkaline phosphatase, parathyroid hormone) and bone biopsy if aluminium osteodystrophy suspected
  - Serum calcium and phosphorus levels to assess mineral metabolism
  - Parathyroid hormone (PTH) levels for secondary hyperparathyroidism assessment
  - Renal function tests (creatinine, urea, eGFR) to evaluate kidney function status
  - Complete blood count (CBC) to assess for microcytic anaemia
  - Bone mineral density (DEXA scan) if osteoporosis or bone disease suspected
  - Neuropsychological testing if cognitive or neurological symptoms present
- Monitoring Frequency: For dialysis patients: baseline test, then annually or semi-annually for stable patients; monthly or more frequently if elevated; for non-dialysis patients with occupational exposure or symptoms: baseline and as clinically indicated
- Complementary Information Tests: Iron studies (ferritin, iron saturation), magnesium and other trace elements, urinalysis, and imaging studies (skeletal surveys, CT) as indicated by clinical presentation
Fasting Required?
- Fasting Requirement: No - fasting is not required for serum aluminium testing
- Sample Collection: Blood drawn via venipuncture into standard collection tubes (typically serum separator tube); can be collected at any time of day
- Medications to Avoid: No medications need to be discontinued; however, inform healthcare provider of all current medications including aluminium-containing antacids or phosphate binders as these may affect test interpretation
- Patient Preparation:
  - No special preparation needed; routine blood draw procedures apply
  - Wear comfortable clothing with accessible arm for blood collection
  - Remain well-hydrated before the test
  - For dialysis patients: test may be scheduled before or after dialysis session; timing consistency is important for trend assessment
  - Inform phlebotomist of concerns regarding aluminum exposure or symptoms
- Important Considerations: Laboratory must use aluminium-free collection tubes and equipment to prevent contamination; results should be reported promptly; serial measurements taken at consistent times enhance reliability of trend interpretation

How our test process works!