Anti Hepatitis E Virus (HEV) - IgG
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Anti-HEV IgG test detects Immunoglobulin G (IgG) antibodies produced by the immune system in response to Hepatitis E Virus infection
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🧪 Anti-Hepatitis E Virus (HEV) – IgG Antibody Test
Parameter | Details |
|---|---|
Full Name | Anti-Hepatitis E Virus (HEV) – IgG Antibodies |
Sample Type | Blood (Serum) |
Fasting Required | ❌ No |
Method | ELISA (Enzyme-Linked Immunosorbent Assay) or CLIA |
🔬 What Is It?
The Anti-HEV IgG test detects Immunoglobulin G (IgG) antibodies produced by the immune system in response to Hepatitis E Virus infection.
- A positive IgG suggests past infection or immunity to HEV.
- HEV is a self-limiting viral infection that primarily affects the liver, similar to Hepatitis A.
- The virus spreads mainly through contaminated water and poor sanitation.
🧠 Organs Involved
Organ | Role |
|---|---|
Liver | Target organ of the HEV virus; site of inflammation |
Immune System | Produces IgG antibodies in response to infection |
🎯 Why Is This Test Done?
Clinical Purpose | Details |
|---|---|
✅ Detect past exposure to HEV | Positive IgG indicates prior infection and likely immunity |
🧪 Part of hepatitis panel | Helps differentiate causes of acute or chronic liver disease |
👶 Useful in pregnancy screening | Especially in endemic areas, as HEV can cause complications |
🌍 Epidemiological or outbreak investigation | Helps track disease exposure in communities |
📊 Test Interpretation
Result | Interpretation |
|---|---|
Positive | Past HEV infection or exposure; immunity likely |
Negative | No detectable past exposure; susceptible to infection |
🧪 Related and Complementary Tests
Test | Use |
|---|---|
Anti-HEV IgM | Detects recent or active infection |
Liver Function Test (LFT) | Assesses liver inflammation (ALT/SGPT, Bilirubin) |
HEV RNA (PCR) | Rarely done; confirms active viremia, mainly in research |
Hepatitis A, B, C tests | Rule out other hepatitis virus causes in liver dysfunction |
⏱️ Timing of Appearance
Marker | When It Appears | Duration |
|---|---|---|
IgM | Within 1–4 weeks of infection | Lasts for ~4–6 months |
IgG | A few weeks after IgM | May persist for years, suggesting long-term immunity |
🌐 Who Should Get This Test?
- Individuals with unexplained elevated liver enzymes
- People in HEV-endemic regions (e.g., parts of Asia, Africa)
- Pregnant women with liver symptoms
- Travelers returning from endemic areas
- In outbreak settings (e.g., contaminated water supplies)
✅ Summary Table
Test | Anti-HEV IgG |
|---|---|
Indicates | Past exposure or immunity to Hepatitis E |
Result Interpretation | Positive = Previous infection; Negative = Susceptible |
Fasting Required | ❌ No |
Sample Type | Serum (Blood) |
Next Steps if Positive | Usually none unless symptomatic or co-infected |
How our test process works!
