Anti Thyroglobulin AntiBody(ATG)

Cancer

Report in 4Hrs

At Home

No Fasting Required

Details

Detects antibodies against thyroglobulin protein.

₹429₹613

30% OFF

Anti-Thyroglobulin Antibody (ATG) - Comprehensive Test Guide

Why is it done?
- Detects autoimmune antibodies against thyroglobulin, a protein produced by the thyroid gland used to monitor thyroid disease progression
- Diagnosis of autoimmune thyroid disorders such as Hashimoto's thyroiditis and Graves' disease
- Monitoring of thyroid cancer patients post-thyroidectomy to detect recurrence or metastasis
- Assessment of patients with unexplained hypothyroidism or hyperthyroidism symptoms
- Evaluation of thyroid nodules and differential diagnosis of thyroid dysfunction
- Long-term surveillance in thyroid cancer patients receiving radioactive iodine therapy
- Investigation of subfertility or recurrent pregnancy loss associated with thyroid autoimmunity
Normal Range
- Normal/Negative Result: < 0.9 IU/mL or < 1.0 IU/mL (depending on laboratory)
- Unit of Measurement: IU/mL (International Units per milliliter)
- Reference ranges vary by laboratory; always consult the specific lab's reference interval
- Negative/Normal: Absence of anti-thyroglobulin antibodies; indicates no autoimmune thyroid disease (or low autoimmune activity)
- Positive/Abnormal: ≥ 1.0 IU/mL indicates presence of anti-thyroglobulin antibodies; suggests autoimmune thyroid disease
- Slightly Elevated (1.0-10 IU/mL): Mild to moderate autoimmune thyroid activity
- Markedly Elevated (> 10 IU/mL): Strong autoimmune response; associated with active thyroid disease
Interpretation
- Positive Result (≥ 1.0 IU/mL):
  - Suggests presence of autoimmune thyroid disease
  - May indicate Hashimoto's thyroiditis (chronic autoimmune thyroiditis)
  - Associated with increased risk of thyroid dysfunction and progression to hypothyroidism
- Negative Result (< 1.0 IU/mL):
  - Indicates absence of anti-thyroglobulin antibodies
  - Does not rule out thyroid disease; some patients with autoimmune thyroid disease may be seronegative
  - Lower risk for thyroid autoimmunity but requires clinical correlation
- Factors Affecting Results:
  - Disease activity and disease duration affect antibody titers
  - Concurrent anti-TPO (thyroid peroxidase) antibodies may coexist
  - Antibody levels may fluctuate over time with disease progression or treatment
  - Pregnancy, stress, and medications can influence autoimmune response
  - In thyroid cancer patients, presence may indicate inadequate tumor removal
- Clinical Significance:
  - Serial measurements more useful than single results for monitoring disease progression
  - Rising titers may indicate disease worsening or inadequate treatment response
  - Declining titers suggest disease improvement or successful treatment
Associated Organs
- Primary Organ System:
  - Thyroid gland (endocrine system)
- Medical Conditions Associated with Abnormal Results:
  - Hashimoto's thyroiditis (chronic autoimmune thyroiditis)
  - Graves' disease (autoimmune hyperthyroidism)
  - Differentiated thyroid cancer (papillary and follicular)
  - Iodine-induced thyroiditis
  - Post-partum thyroiditis
  - Drug-induced thyroid autoimmunity (interferon, checkpoint inhibitors)
  - Silent thyroiditis
- Diseases This Test Helps Diagnose or Monitor:
  - Autoimmune thyroid disease diagnosis and classification
  - Thyroid cancer recurrence detection post-thyroidectomy
  - Assessment of thyroid disease risk in asymptomatic patients
- Potential Complications/Risks Associated with Abnormal Results:
  - Progressive hypothyroidism requiring lifelong thyroid hormone replacement
  - Increased cardiovascular risk if thyroid dysfunction is inadequately managed
  - Subfertility and pregnancy complications in untreated autoimmune thyroiditis
  - Thyroid cancer recurrence if metastatic disease not detected
  - Associated autoimmune conditions (Type 1 diabetes, celiac disease, pernicious anemia)
Follow-up Tests
- Recommended Additional Tests Based on Results:
  - Anti-TPO (thyroid peroxidase) antibodies - to assess concurrent thyroid autoimmunity
  - TSH (thyroid stimulating hormone) - to evaluate thyroid function status
  - Free T4 and Free T3 - to assess thyroid hormone levels
  - TSI (thyroid stimulating immunoglobulin) - if Graves' disease suspected
  - Thyroid ultrasound - to evaluate thyroid structure and nodules
- For Thyroid Cancer Patients:
  - Thyroglobulin level - serum and stimulated (after TSH stimulation or thyroid hormone withdrawal)
  - Radioactive iodine scan - to detect metastatic disease
  - Neck ultrasound - surveillance for lymph node involvement
  - PET-CT scan - if conventional imaging suggests metastases
- Monitoring Frequency:
  - Hashimoto's thyroiditis: Annual TSH monitoring; ATG annually or as clinically indicated
  - Graves' disease: TSH and Anti-TSH receptor antibodies every 3-6 months during treatment
  - Thyroid cancer survivors: Serial thyroglobulin and anti-thyroglobulin levels as part of surveillance protocol
  - High-risk patients: Every 3-6 months during first 1-2 years; then annually if stable
- Complementary Tests:
  - Thyroglobulin measurement - primary marker for thyroid cancer recurrence and follow-up
  - Complete metabolic panel - to assess overall health and liver/kidney function
  - Tissue transglutaminase antibodies - to screen for celiac disease (associated autoimmune disorder)
Fasting Required?
- Fasting Required: NO
- This is a blood test that can be performed regardless of fasting status
- Food and beverages do not affect anti-thyroglobulin antibody levels
- Patient Preparation Requirements:
  - No special preparation required before blood draw
  - Routine venipuncture only; standard blood collection procedures apply
  - Inform phlebotomist if patient has bleeding disorders or is on anticoagulant therapy
- Medications:
  - No medications need to be discontinued for this test
  - Continue all regular medications including thyroid hormone replacement therapy
  - Biotin supplements may interfere with some immunoassays; inform laboratory if taking high-dose biotin
- Special Instructions:
  - For thyroid cancer surveillance, testing ideally performed in morning with consistent timing
  - Avoid iodine-containing products (iodine supplements, some contrast agents) before testing if possible
  - Serial measurements should be done at same laboratory when possible for consistency
  - Notify physician if on immunosuppressive medications or recent blood transfusion

How our test process works!