Aspergillosis IgG antibodies
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Useful for diagnosing Chronic Pulmonary Aspergillosis (CPA) and Allergic Bronchopulmonary Aspergillosis (ABPA)
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🧪 Aspergillosis IgG Antibodies Test
Parameter | Details |
|---|---|
Full Name | Anti-Aspergillus IgG Antibody Test |
Sample Type | Blood (Serum) |
Fasting Required | ❌ No |
Method | ELISA or Immunodiffusion |
Category | Infectious Disease, Allergy & Immunology |
🔬 What Does It Detect?
This test detects IgG antibodies specific to Aspergillus species, a group of molds that can cause asymptomatic colonization, allergic reactions, or chronic invasive disease depending on the patient's immune status.
It is especially useful for diagnosing Chronic Pulmonary Aspergillosis (CPA) and Allergic Bronchopulmonary Aspergillosis (ABPA).
🦠 About Aspergillosis
Aspergillosis is a spectrum of diseases caused by Aspergillus molds, commonly Aspergillus fumigatus.
Form | Description |
|---|---|
Allergic (ABPA) | Seen in asthmatics and cystic fibrosis patients |
Chronic Pulmonary Aspergillosis | Slowly progressive lung infection; occurs in patients with lung damage |
Invasive Aspergillosis | Severe and life-threatening; in immunocompromised patients (e.g., cancer, HIV) |
🧠 Organs Involved
Organ/System | Relevance |
|---|---|
Lungs | Most common site of Aspergillus colonization and infection |
Immune System | IgG antibodies are produced in response to fungal antigens |
Sinuses, CNS (rare) | May be involved in advanced or disseminated cases |
🧪 When Is This Test Ordered?
Clinical Indications | Symptoms/Context |
|---|---|
Suspected Chronic Pulmonary Aspergillosis (CPA) | Chronic cough, fatigue, hemoptysis |
Suspected ABPA | Worsening asthma, mucus plugs, eosinophilia |
To monitor response to treatment | Fall in antibody levels may suggest improvement |
Unexplained cavitary lung lesions on chest imaging | Rule out fungal colonization/infection |
📊 Interpretation
Result | Meaning |
|---|---|
Positive | Suggests current or recent exposure/infection; supports diagnosis of CPA or ABPA |
Negative | Makes chronic aspergillosis less likely but doesn't rule out invasive infection |
High Titer | More suggestive of active infection or colonization |
❗ For invasive aspergillosis, galactomannan antigen, PCR, or IgE tests may be more helpful.
🔄 Tests Often Done Together
Test | Purpose |
|---|---|
Aspergillus IgE | Diagnoses allergic forms (ABPA) |
Chest X-ray / HRCT Chest | Detects cavitations, fungal balls (aspergillomas), infiltrates |
Sputum Culture or PCR | Confirms fungal growth or DNA |
Serum Galactomannan | Marker of invasive aspergillosis |
Eosinophil Count, Total IgE | Supports allergic aspergillosis diagnosis |
📌 Summary Table
Test | Aspergillosis IgG Antibodies |
|---|---|
Sample | Blood (serum) |
Fasting Needed | No |
Indicates | Chronic exposure or infection with Aspergillus species |
Used To Diagnose | Chronic Pulmonary Aspergillosis (CPA), ABPA |
Positive In | Fungal colonization, immune sensitization, or infection |
Not Useful For | Early-stage or invasive aspergillosis alone |
How our test process works!
