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Basic Arthiritis Profile - Female

Bone

23 parameters

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Report in 8Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Small panel for arthritis screening.

₹829₹1,349

39% OFF

Parameters

  • List of Tests
    • Prolactin
    • Urine Complete
    • Anti - Streptolysin O
    • RF
    • ESR
    • CRP

Basic Arthritis Profile - Female

  • Why is it done?
    • This comprehensive test package is designed to screen for, diagnose, and monitor various forms of arthritis and inflammatory joint diseases in women
    • Evaluates systemic inflammatory markers that indicate joint inflammation, autoimmune disease activity, and rheumatologic conditions
    • Prolactin (PRL): Hormone assessment relevant to women as elevated prolactin can be associated with autoimmune conditions like systemic lupus erythematosus (SLE) and may contribute to arthritis development
    • Anti-Streptolysin O (ASO): Detects evidence of recent streptococcal infection, which can trigger post-streptococcal reactive arthritis and rheumatic fever
    • RF (Rheumatoid Factor): Key serological marker for rheumatoid arthritis and other autoimmune conditions
    • ESR (Erythrocyte Sedimentation Rate): Non-specific inflammatory marker indicating degree of systemic inflammation
    • CRP (C-Reactive Protein): Acute phase reactant measuring active inflammation in the body
    • Urine Complete: Screens for renal involvement in systemic autoimmune diseases and monitors kidney function affected by certain arthritis medications
    • Ordered for patients presenting with joint pain, swelling, morning stiffness, or suspected autoimmune arthritis conditions
    • Used for baseline assessment in newly diagnosed arthritis and to monitor disease progression and treatment response
  • Normal Range
    • Prolactin (PRL): 3.34-26.72 ng/mL (normal range for non-pregnant, non-lactating women); Negative/Normal result indicates no endocrine contribution to arthritis
    • Anti-Streptolysin O (ASO): Less than 200 IU/mL (or less than 0.67 µmol/L); Negative result indicates no recent streptococcal infection; values above 200 IU/mL suggest recent or ongoing infection
    • RF (Rheumatoid Factor): Less than 14 IU/mL is considered negative/normal; borderline ranges 14-20 IU/mL may warrant follow-up; positive results greater than 20 IU/mL suggest rheumatoid arthritis or other autoimmune conditions
    • ESR (Erythrocyte Sedimentation Rate): Women under 50 years: less than 20 mm/hr; Women 50 years and above: less than 30 mm/hr; elevated values indicate inflammation
    • CRP (C-Reactive Protein): Less than 3.0 mg/L is normal; values 3.0-10.0 mg/L indicate mild inflammation; greater than 10.0 mg/L suggests significant acute inflammation
    • Urine Complete: Normal results show no protein, glucose, or red/white blood cells; specific gravity 1.005-1.030; pH 4.5-8.0; absence of casts and crystals (except rare hyaline casts)
  • Interpretation
    • Prolactin: Elevated levels (>26.72 ng/mL) may indicate hyperprolactinemia associated with autoimmune diseases; levels above 100 ng/mL suggest pituitary adenoma; moderately elevated levels can enhance autoimmune responses and increase arthritis risk; normal levels support non-endocrine arthritis etiology
    • Anti-Streptolysin O: Elevated levels (>200 IU/mL) indicate recent or current streptococcal infection; persistently elevated levels suggest recent infection; markedly elevated levels (>500 IU/mL) strongly indicate acute streptococcal disease; rising titers on sequential testing confirm recent infection; positive results warrant investigation for post-streptococcal reactive arthritis and acute rheumatic fever
    • RF (Rheumatoid Factor): Positive results (>20 IU/mL) strongly suggest rheumatoid arthritis, especially with elevated inflammatory markers; negative RF does not exclude seronegative rheumatoid arthritis (10-15% of RA cases); very high levels (>60 IU/mL) indicate more aggressive disease; RF positivity also seen in Sjögren's syndrome, lupus, and other autoimmune conditions; clinical correlation essential for diagnosis
    • ESR: Elevated ESR (>20-30 mm/hr depending on age) indicates presence of systemic inflammation; higher values suggest more active disease; ESR is non-specific and rises in infection, inflammation, malignancy, and autoimmune diseases; used as disease activity marker in rheumatoid arthritis and other inflammatory conditions; slower rise/fall compared to CRP; may remain elevated after inflammation resolves
    • CRP: Elevated levels indicate acute phase inflammatory response; values 3.0-10.0 mg/L suggest mild-to-moderate inflammation; levels >10.0 mg/L indicate significant acute inflammation; CRP rises and falls more rapidly than ESR, useful for monitoring acute inflammation; elevated CRP with elevated RF strongly supports rheumatoid arthritis diagnosis; used to assess treatment response
    • Urine Complete: Proteinuria (>150 mg/24hr) may indicate lupus nephritis or other systemic autoimmune involvement; presence of RBCs and WBCs suggest urinary tract involvement; casts indicate kidney disease; presence of glucose suggests diabetes; specific gravity helps assess hydration status; critical for detecting renal involvement in systemic arthritis conditions
    • Combined Pattern Interpretation: Positive RF + elevated ESR/CRP = highly suggestive of rheumatoid arthritis; elevated ESR/CRP + normal RF = seronegative arthritis or other inflammatory conditions; elevated ASO + joint symptoms = post-streptococcal reactive arthritis consideration; abnormal urinalysis + systemic markers = screen for lupus or other systemic diseases
  • Associated Organs
    • Prolactin: Associated with pituitary gland function; elevated prolactin linked to autoimmune thyroiditis and systemic lupus erythematosus; abnormalities may indicate pituitary adenoma or hypothyroidism; relevance to breast tissue and potential lactation issues
    • Anti-Streptolysin O: Related to throat and upper respiratory tract infections; positive results indicate streptococcal exposure affecting heart (rheumatic heart disease), joints (post-streptococcal reactive arthritis), and kidneys (post-streptococcal glomerulonephritis)
    • RF (Rheumatoid Factor): Evaluates immune system and connective tissue; positive RF indicates autoimmune disease primarily affecting synovial joints; associated with inflammatory arthritis potentially affecting multiple joint areas; elevated RF may indicate systemic disease affecting various organs including heart (pericarditis), lungs (pulmonary nodules), and eyes (scleritis)
    • ESR: Reflects systemic inflammation affecting all organ systems; elevated ESR indicates need to evaluate bone marrow, cardiovascular system, and all major organ systems; particularly useful in detecting inflammatory and malignant conditions affecting multiple organs
    • CRP: Acute phase protein produced by liver; elevated CRP indicates hepatic response to systemic inflammation; helps assess inflammation in cardiovascular disease, infection, and rheumatologic conditions; associated with increased cardiovascular risk
    • Urine Complete: Evaluates kidney and urinary tract function; proteinuria suggests glomerulonephritis common in lupus and other systemic diseases; hematuria may indicate glomerular disease or urinary tract involvement in autoimmune conditions; early detection of renal involvement critical for managing systemic arthritis
    • Comprehensive Impact: Results collectively assess synovial joints (primary), immune system (autoimmune markers), endocrine system (prolactin), kidneys (urinalysis), and systemic inflammatory status affecting multiple organ systems
  • Follow-up Tests
    • If Prolactin Elevated: Serum free thyroxine (TSH) to rule out hypothyroidism; prolactin level repeat testing; pituitary MRI if markedly elevated (>100 ng/mL); dopamine agonist medication consideration
    • If Anti-Streptolysin O Positive: Throat culture if not already performed; 2-3 week repeat ASO titer to document rising pattern; echocardiography if rheumatic heart disease suspected; anti-DNase B testing for confirmation; urinalysis for proteinuria/hematuria if post-streptococcal glomerulonephritis suspected; ECG to assess cardiac involvement
    • If RF Positive: Anti-CCP (anti-cyclic citrullinated peptide) antibodies for rheumatoid arthritis confirmation; complete metabolic panel (liver and kidney function); ANA (antinuclear antibody) testing if systemic disease suspected; complement levels (C3, C4); thyroid function tests; imaging studies (X-rays, ultrasound, or MRI of affected joints); repeat testing every 3-6 months to monitor disease activity
    • If ESR Elevated: Complete metabolic panel for organ dysfunction; CBC for anemia or leukemia; chest X-ray to rule out infection or malignancy; if persistently elevated, periodic monitoring (monthly or every 3 months); CRP testing for comparison; further workup based on clinical presentation and other findings
    • If CRP Elevated: Complete metabolic panel; ESR for comparison; blood cultures if infection suspected; chest imaging if pneumonia considered; repeat CRP testing to monitor response to treatment (typically 2-4 weeks after therapy initiation); lipid panel given cardiovascular risk association
    • If Urine Abnormal: 24-hour urine protein collection if proteinuria detected; urinary creatinine; kidney function tests (serum creatinine, BUN); renal ultrasound if structural abnormalities suspected; ANA testing and complement levels if lupus nephritis considered; blood cultures if infection indicated by pyuria; renal biopsy if significant proteinuria or hematuria with abnormal kidney function
    • Comprehensive Follow-up Strategy: Serologic panels (ANA, ENA, anti-dsDNA) if systemic autoimmune disease suspected; rheumatology referral for RF-positive patients; imaging studies (radiographs, ultrasound, MRI) for joint assessment; baseline and periodic CBC, liver function, and kidney function monitoring on disease-modifying therapies; repeat inflammation markers every 3-6 months during treatment
  • Fasting Required?
    • Overall Fasting Requirement: PARTIAL FASTING RECOMMENDED - 8-12 hours overnight fasting is recommended for optimal results
    • Prolactin: Fasting not strictly required, but recommended as food intake can slightly affect levels; ideally collect 3-4 hours after waking to avoid diurnal variations; avoid physical stress or breast manipulation before collection
    • Anti-Streptolysin O (ASO): Fasting not required; can be drawn at any time regardless of food intake
    • RF (Rheumatoid Factor): Fasting not strictly required, but morning collection after overnight fasting is recommended for consistency and to minimize inflammation variations
    • ESR (Erythrocyte Sedimentation Rate): Fasting not required; can be drawn at any time; collection in morning recommended for standardization
    • CRP (C-Reactive Protein): Fasting not required; can be drawn at any time; early morning collection preferred for baseline measurements
    • Urine Complete: Fasting not required; first morning urine preferred for consistency; patient should clean genital area and collect midstream urine sample (10-15 mL) in sterile container; if menstruating, inform laboratory as RBCs in urine may be contamination
    • Medication Considerations: Avoid hormone-containing medications (birth control pills, HRT) 24 hours before collection if possible as these affect prolactin levels; notify laboratory of current medications as some antibiotics affect ASO titers; NSAIDs and corticosteroids can temporarily suppress inflammatory markers and should ideally be withheld 48-72 hours before testing if possible (consult physician); continue chronic medications unless specifically instructed otherwise
    • General Preparation Instructions: Schedule testing in early morning (7:00-9:00 AM) when possible for consistency; avoid strenuous exercise 24 hours before testing as physical activity elevates inflammatory markers; avoid stress and get adequate sleep night before collection; stay well-hydrated but do not overhydrate before blood draw; wear loose-fitting clothing to facilitate venipuncture; inform technician of any current illness or recent infections that may affect results; fasting blood draw (if ordered) should be completed before 10:00 AM
    • Sample Collection and Handling: Serum samples require venipuncture into appropriate tubes (SST/serum separator tubes for most markers); urine sample must be collected in sterile, container-provided collection cup; samples should be processed within 1-2 hours of collection for optimal results; keep samples at room temperature during transport unless instructed otherwise

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