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Basic - Fever Profile

Bacterial/ Viral

37 parameters

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Details

Panel for fever causes (malaria, dengue, typhoid).

7991,299

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Parameters

  • List of Tests
    • SGPT
    • Urine Complete
    • Smear for Malarial Parasite (MP)
    • ESR
    • Widal Tube Tet (24H) - Tyhpi (O,H), Paratyphi (A, B)
    • CBC - Complete Hemogram (28)

Basic - Fever Profile

  • Why is it done?
    • Comprehensive screening tool designed to identify the underlying cause of fever in patients presenting with unexplained pyrexia
    • Diagnosis of common tropical febrile illnesses including typhoid fever, paratyphoid fever, and malaria which are prevalent in endemic regions
    • Detection of systemic infections and inflammatory responses through comprehensive hemogram and inflammatory markers
    • Assessment of liver function and hepatic involvement, commonly affected in febrile illnesses such as typhoid and malaria
    • Evaluation of urinary tract involvement and renal complications during systemic infections
    • Ordered in patients with fever lasting more than 3-5 days, fever of unknown origin (FUO), or suspected enteric fever or malaria
    • Utilized to guide antibiotic therapy selection by identifying specific pathogens and determining appropriate treatment strategies
    • Individual tests work synergistically: Widal detects bacterial antigens, malarial smear identifies parasites, CBC assesses infection severity, ESR measures inflammation, SGPT evaluates hepatic damage, and urine complete identifies secondary organ involvement
  • Normal Range
    • SGPT (Serum Glutamic-Pyruvic Transaminase): 7-55 IU/L (International Units per Liter); Values up to 40 IU/L are considered normal in many laboratories; Slight variations exist between male and female populations; Normal indicates no acute hepatic damage
    • Urine Complete: Color: pale yellow to colorless; pH: 4.5-8.0; Specific gravity: 1.005-1.030; Protein: Negative (trace amounts up to 30 mg/dL acceptable); Glucose: Negative; Ketones: Negative; RBCs: 0-3 per high power field; WBCs: 0-5 per high power field; Bacteria: Negative; Crystals: Negative to occasional; Casts: Negative or 0-2 hyaline casts
    • Smear for Malarial Parasite (MP): Negative for malarial parasites; No Plasmodium species identified (P. falciparum, P. vivax, P. ovale, P. malariae, P. knowlesi); Absence of intra-erythrocytic parasites on thin and thick blood films; Negative result indicates no active malaria infection
    • ESR (Erythrocyte Sedimentation Rate): Males: 0-15 mm/hour; Females: 0-20 mm/hour; Age-specific variations apply (increases with age); Normal ESR indicates minimal systemic inflammation; Measured in millimeters of fall in 1 hour by Westergren method
    • Widal Tube Test (24 hours) - Typhoid and Paratyphoid: Negative for all antigens: O (Somatic), H (Flagellar), and Paratyphoid A and B; Negative result indicates absence of current or past Salmonella infection; Titers <1:40 or <1:80 typically considered negative depending on laboratory standards; No agglutination observed in tube test
    • CBC - Complete Hemogram (28 parameters): Hemoglobin: 13.5-17.5 g/dL (males), 12.0-15.5 g/dL (females); RBC Count: 4.5-5.5 million/μL (males), 4.0-5.0 million/μL (females); WBC Count: 4,500-11,000/μL; Platelets: 150,000-400,000/μL; Packed Cell Volume (PCV): 41-50% (males), 36-44% (females); MCV: 80-100 fL; MCH: 27-33 pg; MCHC: 32-36 g/dL; Differential counts within normal ranges for neutrophils, lymphocytes, monocytes, eosinophils, and basophils
  • Interpretation
    • SGPT Interpretation: Elevated SGPT (>55 IU/L) indicates hepatocellular injury or inflammation; Mild elevation (1-3 times upper limit of normal) suggests acute hepatitis or early liver involvement; Marked elevation (>5 times normal) indicates severe hepatic damage; In typhoid fever, elevation is typically mild to moderate; In malaria, hepatic involvement causes variable elevation; Normal SGPT does not exclude systemic infection; Prolonged elevation warrants investigation for chronic liver disease
    • Urine Complete Interpretation: Proteinuria (protein 2+, 3+, or 4+) suggests renal involvement or urinary tract infection; Presence of RBCs and WBCs indicates urinary tract pathology, hematuria, or secondary infection; Positive nitrites and leukocyte esterase suggest bacterial UTI; Crystals and casts may indicate renal stress; Abnormal color (dark, tea-colored) suggests myoglobinuria or hemoglobinuria; Elevated specific gravity indicates dehydration common in fever; Normal urine helps exclude renal complications; Ketonuria may indicate metabolic stress or dehydration
    • Malarial Parasite Smear Interpretation: Positive smear confirms active malaria infection; Species identification crucial: P. falciparum (severe), P. vivax and P. ovale (mild), P. malariae (benign), P. knowlesi (potentially severe); Parasite density determines disease severity (mild: <1%, moderate: 1-5%, severe: >5%); Negative smear does not exclude malaria; requires repeat testing in high clinical suspicion; Single negative does not rule out infection due to low parasitemia levels; Multiple negative smears on consecutive days effectively excludes diagnosis
    • ESR Interpretation: Elevated ESR (>20 mm/hr in males, >25 mm/hr in females) indicates systemic inflammation or infection; Mild elevation (20-40 mm/hr) suggests acute infection, fever, or inflammation; Moderate elevation (40-60 mm/hr) indicates significant inflammatory response; Marked elevation (>100 mm/hr) suggests severe infection or chronic disease; In typhoid fever, ESR shows progressive elevation through illness course; In malaria, ESR elevation correlates with parasite load; Normal ESR does not exclude fever; ESR is non-specific but useful trend marker; Acute infections typically show elevation before normalization with recovery
    • Widal Test Interpretation: Positive O (Somatic) antigen suggests acute typhoid infection; Positive H (Flagellar) antigen may indicate acute or chronic infection, or previous immunization; Titers ≥1:80 in acute illness suggestive of typhoid; Four-fold rise in paired sera (acute and convalescent) confirms diagnosis; Paratyphoid A and B positivity indicates Salmonella paratyphoid infection; Cross-reactivity possible with other Gram-negative infections; Geographic variation affects interpretation; Previous immunization can cause false positivity; Negative Widal does not exclude typhoid in first week of illness; Clinical correlation essential for accurate interpretation; Low endemic areas have better predictive value for positive results
    • CBC - Complete Hemogram Interpretation: Elevated WBC count (>11,000/μL) indicates active infection or inflammatory response; Left shift (increased neutrophils, immature forms) suggests acute bacterial infection; Lymphocytosis suggests viral infection or early typhoid; Anemia (low hemoglobin) occurs in malaria, chronic infection, or hemolysis; Thrombocytopenia (<150,000/μL) indicates bone marrow involvement, DIC, or severe infection; Normal or decreased WBC in typhoid contrasts with elevated WBC in other infections; RBC indices help classify anemia type; Relative lymphocytosis in typhoid is characteristic; Platelet reduction correlates with malaria severity and dengue; Eosinophilia unusual in fever unless parasitic co-infection; Serial CBCs track infection progression and treatment response
  • Associated Organs
    • SGPT - Liver and Hepatic System: Primary hepatocyte injury indicator; Identifies acute hepatitis, cirrhosis, fatty liver disease, and drug-induced liver injury; Elevated levels indicate hepatic inflammation in typhoid fever, malaria, and dengue; Hepatomegaly common in febrile illnesses; Liver dysfunction affects drug metabolism and immune response; Complications include coagulopathy, encephalopathy, and acute liver failure in severe cases; Recovery monitored by SGPT normalization
    • Urine Complete - Kidney and Urinary System: Detects acute kidney injury (AKI) through proteinuria and elevated specific gravity; Identifies urinary tract infection and pyelonephritis during systemic fever; Glomerulonephritis indicated by hematuria and proteinuria; Rhabdomyolysis detection via myoglobin presence; Hemoglobinuria suggests severe hemolytic disease; Dehydration assessment through specific gravity changes; Renal complications in severe malaria and septic typhoid; Acute renal failure possible with severe infections; Electrolyte disturbances accompany renal involvement
    • Malarial Parasite Smear - Red Blood Cells and Immune System: Direct parasitization of erythrocytes causes hemolysis; Severe malaria causes cerebral involvement and multi-organ failure; Hemolytic anemia results from massive RBC destruction; Immune system dysregulation occurs in acute infection; Cytokine-mediated inflammation affects spleen and liver; Vascular endothelial activation leads to plasma leak; DIC complications from severe malaria; Acidosis and organ dysfunction in severe parasitemia; Antimalarial resistance affects treatment success
    • ESR - Systemic Inflammatory Response: Non-specific marker of systemic inflammation affecting multiple organ systems; Reflects acute phase response in liver producing inflammatory proteins; Indirectly assesses vascular endothelial activation; Elevated in sepsis and severe infections; Tracks disease progression and response to antimicrobial therapy; Associated with increased vascular permeability and fluid shifts; Correlates with fever magnitude and systemic inflammatory burden; Recovery monitored through ESR normalization; Persistent elevation suggests chronic infection or complications
    • Widal Test - Gastrointestinal and Systemic Bacterial Infection: Diagnoses Salmonella typhi and paratyphi infections affecting GI system; Bacteria localize in Peyer's patches and mesenteric lymph nodes; Enteric fever causes intestinal perforation and peritonitis in severe cases; Bacteremia leads to multi-organ involvement; Pneumonia and myocarditis complications in systemic spread; Hepatosplenomegaly common with positive Widal; Rose spots (rash) indicate systemic bacterial dissemination; Intestinal ulceration and bleeding in third week; Neurologic complications including typhoid encephalopathy possible
    • CBC - Complete Hemogram - Multiple Organ Systems: Bone marrow assessment through cell counts and morphology; WBC elevation indicates immune system activation against infection; Anemia reflects bone marrow suppression or hemolysis from malaria; Thrombocytopenia suggests DIC or spleen sequestration; Hemoglobin abnormalities affect oxygen delivery to tissues; Lymphoid tissue activation in lymphocytosis; Tissue damage indicated by immature cell release; Multi-organ failure reflected in severe pancytopenia; Sepsis and shock correlate with markedly elevated WBC; Recovery assessed through normalization of all parameters
  • Follow-up Tests
    • SGPT Abnormal Results - Follow-up: SGOT (Serum Glutamic-Oxaloacetic Transaminase) to assess hepatic damage pattern and calculate AST/ALT ratio; Bilirubin (total and direct) to evaluate hepatic conjugation and cholestasis; Alkaline Phosphatase (ALP) to detect biliary involvement; Albumin and Total Protein to assess synthetic hepatic function; INR and PT to evaluate coagulation and liver synthetic function; Ultrasound abdomen if hepatomegaly suspected or persistent elevation; Hepatitis serology (HAV, HBV, HCV) if chronic elevation present; Repeat SGPT every 3-5 days during acute illness to trend improvement
    • Urine Complete Abnormal Results - Follow-up: Urine culture and sensitivity if bacteria or pyuria detected to identify uropathogens; Serum creatinine and BUN to assess renal function status; eGFR calculation to stage acute kidney injury; Urine electrolytes and osmolality if renal injury suspected; Renal ultrasound if obstructive uropathy suggested; Repeat urinalysis after treatment completion; 24-hour urine protein collection if significant proteinuria present; Kidney biopsy if persistent glomerulonephritis indicated
    • Malarial Parasite Smear Positive Results - Follow-up: Quantitative buffy coat (QBC) for parasite density estimation; Rapid diagnostic tests (RDT) for confirmation and species differentiation; Molecular PCR for species identification and antimalarial resistance detection; Repeat smears every 12-24 hours for parasite clearance monitoring; Hemoglobin repeat to monitor anemia progression; LDH (Lactate Dehydrogenase) to assess hemolysis severity; Creatinine and electrolytes for organ dysfunction screening; Tissue schizonticidal drug levels if treatment failure suspected; Follow-up smear at treatment completion to confirm parasite clearance
    • ESR Elevated Results - Follow-up: CRP (C-Reactive Protein) as more specific acute phase reactant; Blood culture to identify bacteremia and guide antibiotic therapy; Repeat ESR weekly to monitor therapeutic response; Imaging studies (chest X-ray, ultrasound) if localizing infection source needed; Echocardiography if endocarditis suspected from elevated ESR; Lumbar puncture if meningitis or CNS involvement considered; Repeat CBC to correlate with WBC and hemoglobin trends; Tissue biopsy if chronic elevation without obvious cause
    • Widal Test Positive Results - Follow-up: Blood culture (Salmonella typhi/paratyphi isolation) for definitive diagnosis and antibiotic susceptibility; Convalescent serum Widal at 3-4 weeks to demonstrate rise (confirms acute infection); Bone marrow culture if blood culture negative but suspicion high; Stool culture if carrier state suspected after recovery; Chest X-ray to exclude respiratory complications; Abdominal imaging if intestinal perforation suspected; CSF analysis if neurologic complications present; Repeat clinical assessment every 5-7 days during treatment; Follow-up blood cultures post-treatment to confirm sterilization
    • CBC Abnormal Results - Follow-up: Peripheral blood smear examination if abnormal cells or parasites noted; Blood culture if elevated WBC with left shift suggesting bacteremia; Reticulocyte count if anemia present to assess bone marrow response; Iron studies if microcytic anemia detected; Coagulation studies (PT, aPTT, fibrinogen) if thrombocytopenia marked; D-dimer and fibrin degradation products if DIC suspected; Repeat CBC every 2-3 days during acute illness to track response; Bone marrow aspirate if persistent cytopenias or atypical findings; Repeat hemogram at treatment completion and 1-2 weeks post-recovery to confirm normalization
  • Fasting Required?
    • Overall Fever Profile: No strict fasting required for most components, though fasting may be recommended for SGPT optimal results
    • Specific Test Recommendations:
    • SGPT: Preferably fasting 8-12 hours overnight; avoid heavy fatty meals 24 hours prior; alcohol consumption avoid 24 hours before test; certain medications (acetaminophen, valproic acid) can affect results
    • Urine Complete: First morning midstream urine sample preferred; no specific fasting required; adequate hydration necessary but avoid excessive fluid intake immediately before collection
    • Malarial Parasite Smear: No fasting required; blood collected preferably during fever spike for optimal parasite visualization; timing important for P. vivax and P. ovale (fever every 48 hours) and P. falciparum (fever every 36-48 hours)
    • ESR: No fasting required; proper collection technique crucial; must be performed within 2 hours of blood draw; ensure patient not dehydrated
    • Widal Test: No fasting required; can be drawn during fever or after resolution; timing affects antibody titers (negative in first 3-5 days, peaks at 1-2 weeks); paired sera collection recommended when possible
    • CBC: No fasting required; timing of collection can affect certain parameters; early morning sample preferred for consistency; patient should not be overtired or recently stressed
    • General Patient Preparation:
    • Avoid strenuous exercise 24 hours prior to testing (affects ESR and CBC parameters)
    • Adequate hydration recommended (3-4 liters water daily unless contraindicated) for optimal urine sample and blood collection
    • Medications: Do not discontinue regular medications without physician guidance; antifebrile medications do not affect most test accuracy; antimalarial drugs should not be started before blood draw for MP smear
    • Collection timing: Optimal within 3-5 days of fever onset for Widal test; malaria smear during fever peak; any time during acute illness for CBC, SGPT, and ESR
    • Stress and anxiety should be minimized as they can elevate WBC and affect other parameters; patient should rest 15 minutes before blood draw
    • Recent blood transfusions should be documented as they affect CBC interpretation
    • Recent antimalarial or antibiotic use should be communicated to laboratory for accurate result interpretation

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