Beta 2 Glycoprotein 1 - IgG
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These antiphospholipid antibodies can increase the risk of abnormal blood clotting (thrombosis) and complications in pregnancy
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🧪 Beta-2 Glycoprotein 1 IgG Antibodies Test
Parameter | Details |
|---|---|
Full Name | Beta-2 Glycoprotein 1 Antibody, IgG |
Sample Type | Blood (Serum) |
Fasting Required | ❌ No |
Method | ELISA (Enzyme-Linked Immunosorbent Assay) |
Test Type | Autoimmune / Clotting disorder screening |
Turnaround Time | 2–4 days |
🧬 What Are Beta-2 Glycoprotein 1 Antibodies?
Beta-2 Glycoprotein 1 (β2-GP1) is a protein found in the blood that binds to phospholipids on cell membranes. In some autoimmune disorders, the immune system mistakenly creates antibodies (IgG, IgM, or IgA) against β2-GP1. These antiphospholipid antibodies can increase the risk of abnormal blood clotting (thrombosis) and complications in pregnancy.
🧠 Organs & Systems Involved
System | Impact |
|---|---|
Circulatory | Increased risk of deep vein thrombosis (DVT) and stroke |
Reproductive | Recurrent miscarriages, fetal growth restriction |
Immune system | Associated with autoimmune diseases like systemic lupus erythematosus |
🎯 Why Is This Test Done?
Purpose | Details |
|---|---|
✅ Diagnose Antiphospholipid Syndrome (APS) | A major autoimmune clotting disorder |
👩🍼 Evaluate causes of recurrent pregnancy loss | Especially in 2nd/3rd trimester |
🩸 Investigate unexplained arterial or venous thrombosis | Especially in young individuals |
♻️ Monitor autoimmune disease activity | Often in lupus patients with clotting symptoms |
📊 Interpretation
Result | Interpretation |
|---|---|
Negative | No significant autoantibodies against β2-GP1; APS unlikely |
Borderline/Low Positive | May be transient due to infection or medication |
Positive (high titer) | Suggestive of APS, especially if confirmed in 12 weeks with clinical symptoms |
🔁 Repeat testing after 12 weeks is required to confirm persistent positivity for APS diagnosis.
🧪 Part of a Larger Panel
Beta-2 GP1 antibodies are typically tested as part of the Antiphospholipid Antibody Panel, which includes:
Test | Role |
|---|---|
Lupus Anticoagulant | Most specific test for APS |
Anticardiolipin antibodies (IgG/IgM) | Often elevated in APS |
Beta-2 Glycoprotein 1 (IgG, IgM) | Adds specificity; a key criterion for APS diagnosis |
🩺 Associated Conditions
Condition | Relevance |
|---|---|
Primary Antiphospholipid Syndrome (APS) | Diagnosed based on antibody presence + clinical signs |
Systemic Lupus Erythematosus (SLE) | Frequently coexists with APS |
Recurrent pregnancy loss | IgG positivity linked to 2nd trimester miscarriages |
Stroke / Heart Attack in young adults | May be autoimmune/clotting related |
🔄 Recommended Further Diagnostics
Test | Why |
|---|---|
Anticardiolipin Antibodies (IgG, IgM) | Complements β2-GP1 in APS diagnosis |
Lupus Anticoagulant Panel | Most specific for clotting risk |
ANA, Anti-dsDNA | Screen for coexisting lupus |
PT/INR, aPTT | Assess clotting function |
Ultrasound / Doppler | To detect existing clots in limbs or pelvis |
🧾 Summary Table
Test | Beta-2 Glycoprotein 1 IgG |
|---|---|
Organ/System | Immune, Vascular, Reproductive |
Indicates | Risk of clotting disorders, autoimmune diseases |
Clinical Use | APS diagnosis, pregnancy monitoring, thrombosis evaluation |
Fasting Required | ❌ No |
Recommended With | aCL IgG/IgM, Lupus anticoagulant, ANA |
How our test process works!
