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Blood Toxic Element Profile

Blood

9 parameters

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Report in 24Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Panel of toxic metals (lead, mercury, arsenic, etc.).

₹999₹1,790

44% OFF

Parameters

  • List of Tests
    • Arsenic
    • Cadmium
    • Chromium
    • Cobalt
    • Lead
    • Mercury
    • Selenium
    • Barium
    • Caesium

Blood Toxic Element Profile

  • Why is it done?
    • Detects and measures the presence of potentially harmful heavy metals and toxic elements in the bloodstream that may accumulate from environmental, occupational, or dietary exposure
    • Assesses occupational exposure risk in workers handling metals, chemicals, or pollutants in manufacturing, mining, construction, or industrial settings
    • Evaluates unexplained symptoms such as fatigue, neurological dysfunction, gastrointestinal disturbances, or cognitive impairment that may suggest toxic metal exposure
    • Screens for environmental exposure from contaminated water sources, lead-based paint, pesticides, or air pollution in residential or geographic locations
    • Monitors patients undergoing chelation therapy or heavy metal detoxification treatments to assess treatment efficacy
    • Investigates suspected acute or chronic poisoning cases from accidental ingestion or deliberate exposure to toxic substances
    • Provides comprehensive toxic element screening through nine complementary tests that collectively assess systemic burden of hazardous metals and their potential health impacts
  • Normal Range
    • Arsenic (As): <5 μg/L (micrograms per liter); levels below this threshold indicate no clinically significant exposure; some background level is normal from dietary sources
    • Cadmium (Cd): <0.5 μg/L in non-smokers, <1.0 μg/L in smokers; higher baseline in smokers due to tobacco exposure; completely avoidable element with no physiological requirement
    • Chromium (Cr): 0.1-0.3 μg/L (measured as Cr-III); trace amounts essential as a trace mineral for glucose metabolism, though Cr-VI is toxic form; reference ranges may vary by laboratory
    • Cobalt (Co): <0.5 μg/L; essentially no physiological requirement; presence above normal indicates occupational or environmental exposure rather than metabolic necessity
    • Lead (Pb): <5 μg/dL (micrograms per deciliter); CDC recommends action level of 5 μg/dL in children; no safe threshold exists, particularly for developing nervous systems
    • Mercury (Hg): <5 μg/L for total mercury; organic mercury (methylmercury) particularly hazardous; levels vary based on fish consumption patterns and dental amalgam status
    • Selenium (Se): 70-150 μg/L; essential trace element with narrow therapeutic window between deficiency and toxicity; required for selenoprotein synthesis and antioxidant defense
    • Barium (Ba): <0.5 μg/L; soluble barium salts are toxic; insoluble compounds such as barium sulfate used in medical imaging do not contribute to serum levels
    • Caesium (Cs): <0.05 μg/L; radioactive and stable isotopes possible; no physiological role; elevated levels indicate specific radioactive contamination or industrial exposure
  • Interpretation
    • Arsenic elevation (>5 μg/L) indicates acute or chronic exposure; levels 5-50 μg/L suggest occupational/environmental exposure; >50 μg/L warrants urgent clinical intervention; exposure sources include contaminated groundwater, seafood, pesticides, and occupational hazards; organic arsenic (seafood) less toxic than inorganic forms
    • Cadmium elevation (>0.5 μg/L non-smokers or >1.0 μg/L smokers) indicates significant exposure; half-life of 20-30 years causes cumulative toxicity; primary sources include smoking, contaminated shellfish, refined grains, and occupational exposure in battery/plating industries; bioaccumulates in kidneys causing Itai-itai disease
    • Chromium elevation (>0.3 μg/L) suggests occupational exposure in welding, tanning, or pigment industries; Cr-VI more toxic than Cr-III; impairs glucose tolerance and may damage kidneys; low levels (<0.1 μg/L) may indicate deficiency affecting metabolic control
    • Cobalt elevation (>0.5 μg/L) typically indicates occupational exposure in mining, metal alloy manufacturing, or tool production; associated with hard metal lung disease and cardiomyopathy; minimal dietary contribution in normal circumstances
    • Lead elevation (>5 μg/dL) represents abnormal exposure; <10 μg/dL associated with developmental delays and learning difficulties in children; 10-25 μg/dL warrants intervention and source investigation; >25 μg/dL indicates significant poisoning requiring immediate medical management; bioaccumulates in bones affecting skeletal development
    • Mercury elevation (>5 μg/L) indicates exposure concern; methylmercury from fish consumption particularly neurotoxic; occupational exposure possible in dental offices, laboratories, or manufacturing; crosses blood-brain barrier affecting neurological function; mercury vapor inhalation acute hazard in industrial settings
    • Selenium <70 μg/L indicates deficiency associated with impaired thyroid function, weakened immunity, and increased cardiovascular risk; 70-150 μg/L optimal range; >150 μg/L suggests selenium toxicity causing alopecia, brittle nails, gastrointestinal distress, and peripheral neuropathy; geographic variation in dietary availability
    • Barium elevation (>0.5 μg/L) suggests exposure to soluble barium salts from contaminated drinking water, industrial exposure, or pesticide residues; barium sulfate from medical imaging does not elevate blood levels; hypokalemia commonly accompanies barium toxicity
    • Caesium elevation (>0.05 μg/L) warrants investigation for radioactive contamination source; may indicate exposure from nuclear accidents, industrial releases, or specific occupational hazards; stable caesium displacement of potassium affects electrolyte balance; bioaccumulates in soft tissues
  • Associated Organs
    • Arsenic: Primarily affects gastrointestinal tract (acute toxicity), liver (cirrhosis and hepatotoxicity), kidneys (nephrotoxicity), and nervous system (peripheral neuropathy); classified as human carcinogen affecting multiple organ systems; chronic exposure associated with skin lesions, diabetes, and cardiovascular disease
    • Cadmium: Primary target organs are kidneys (glomerular and tubular damage, proteinuria) and bones (osteoporosis, Itai-itai disease from calcium-magnesium dysregulation); also damages liver, lungs (emphysema with chronic inhalation), and prostate; replaces zinc in multiple enzyme systems causing dysfunction
    • Chromium (Cr-VI): Damages respiratory system (lung cancer, asthma), kidneys (glomerulonephritis, acute tubular necrosis), liver, and gastrointestinal tract; Cr-III generally low toxicity but Cr-VI highly mutagenic; occupational exposure primarily through inhalation causing significant pulmonary complications
    • Cobalt: Affects lungs (hard metal lung disease, pneumoconiosis), heart (cardiomyopathy, congestive heart failure), and thyroid gland (goiter with chronic exposure); occupational disease primarily affecting metal workers; myocardial toxicity cumulative and potentially irreversible
    • Lead: Primarily affects nervous system (encephalopathy, developmental neurotoxicity, cognitive impairment in children), hematopoietic system (hemolytic anemia, reduced hemoglobin synthesis), kidneys (nephropathy, decreased filtration rate), and reproductive organs (reduced fertility, miscarriage); accumulates in bones serving as reservoir
    • Mercury: Damages central nervous system (tremors, cognitive dysfunction, personality changes, Minamata disease from methylmercury), kidneys (membranous glomerulonephritis), and eyes (visual constriction, visual disturbances); affects fetal development during pregnancy; methylmercury particularly neurotoxic crossing blood-brain barrier
    • Selenium: Deficiency impairs thyroid function (decreased T4 synthesis and conversion), immune system (impaired T-cell response), and antioxidant defense; excess causes selenosis affecting hair, nails, gastrointestinal system, and nervous system (peripheral neuropathy); essential for glutathione peroxidase and thioredoxin reductase function
    • Barium: Primarily affects cardiovascular system (hypertension from potassium displacement, arrhythmias), muscles (hypokalemia-induced paralysis, weakness), and gastrointestinal tract (constipation, acute gastroenteritis); chronic exposure affects kidneys and causes electrolyte imbalance
    • Caesium: Affects cellular function through potassium displacement disrupting electrolyte balance; distributes throughout soft tissues particularly muscle; affects kidney function and acid-base balance; radioactive isotopes damage tissues through radiation; bioaccumulation in muscle tissue concerning for chronic exposure
  • Follow-up Tests
    • Arsenic: Urine arsenic speciation testing to differentiate organic vs. inorganic forms; 24-hour urine collection for assessment of total body burden; liver function tests (AST, ALT, alkaline phosphatase, bilirubin) to evaluate hepatotoxicity; renal function panel; nerve conduction studies if peripheral neuropathy suspected; repeat serum testing at 1-3 month intervals during chelation therapy
    • Cadmium: 24-hour urine cadmium (more accurate than blood for chronic exposure assessment); serum creatinine and glomerular filtration rate to assess kidney function; urinalysis for proteinuria indicating renal damage; bone mineral density scan if osteoporosis suspected; repeat testing monthly during chelation and then quarterly for 1 year post-exposure cessation
    • Chromium: Occupational lung function tests (spirometry, DLCO) for workers with exposure; chest X-ray if respiratory symptoms present; renal function assessment; glucose tolerance testing if diabetes symptoms emerge; urinary chromium levels in occupationally exposed individuals; annual monitoring in high-risk occupational groups
    • Cobalt: High-resolution CT chest to evaluate for hard metal lung disease; pulmonary function testing; echocardiography if cardiomyopathy suspected; thyroid function tests (TSH, free T4); chest X-ray for pneumoconiosis assessment; annual occupational health surveillance in at-risk workers; baseline and periodic lung screening
    • Lead: Zinc protoporphyrin (ZPP) testing indicating lead-induced heme synthesis impairment; complete blood count for anemia assessment; renal function panel and urinalysis; developmental screening in children; repeat testing at 2-4 week intervals after exposure cessation; 24-hour urine lead if chelation therapy considered; bone lead estimation if chronic exposure history
    • Mercury: Hair mercury analysis reflecting chronic methylmercury exposure; urine mercury testing for inorganic mercury; neuropsychological testing if tremor or cognitive changes noted; ophthalmologic examination; audiometry; renal function assessment; repeat serum mercury levels weekly during chelation, then monthly for several months; fish consumption dietary assessment
    • Selenium: Thyroid function panel (TSH, free T4, free T3, antibodies) particularly important; glutathione peroxidase activity testing; plasma glutathione levels; urinary selenium excretion; complete metabolic panel; repeat testing 4-6 weeks after intervention; assessment of dietary selenium sources; plasma selenium in symptomatic patients
    • Barium: Serum electrolytes particularly potassium and magnesium levels; electrocardiography to assess for arrhythmias from hypokalemia; renal function tests; chest X-ray if inhalation exposure suspected; urine barium excretion assessment; repeat electrolytes frequently during acute exposure management; skeletal imaging if chronic poisoning suspected
    • Caesium: Urine caesium levels reflecting total body burden; serum electrolytes particularly potassium; whole-body counting or gamma imaging if radioactive caesium isotopes involved; thyroid function testing; renal function assessment; repeat blood caesium levels weekly for acute exposure, monthly during recovery; radiation safety consultation if radioactive contamination confirmed
  • Fasting Required?
    • Fasting is NOT required for the Blood Toxic Element Profile; the test measures heavy metal and elemental levels in serum that are not significantly affected by food intake
    • No specific dietary restrictions are necessary prior to testing; normal meal intake is acceptable; however, avoiding specific high-metal foods may be recommended only in specific contexts (e.g., limiting high-mercury fish 48 hours before testing if detailed exposure assessment needed)
    • Patients should avoid herbal supplements containing potentially heavy metals (some traditional remedies, particularly imported supplements) for 24-48 hours prior to testing if assessing occupational vs. supplemental exposure source
    • No medication restrictions; most medications do not interfere with toxic element measurements; however, chelation therapy agents should be documented as their use directly affects metal levels being measured
    • No special hydration requirements; normal fluid intake is appropriate; adequate hydration may slightly improve vein access but is not obligatory for test accuracy
    • Timing considerations: If assessing occupational exposure, samples collected at the end of workshift may show higher levels; baseline samples preferably collected before high-exposure periods
    • Patient should be seated for at least 5 minutes before venipuncture to ensure stable vital signs; collection tube used must be specifically metal-free (acid-washed tubes) to prevent contamination during specimen collection process
    • Avoid heavy metal exposure immediately prior to testing (e.g., metal grinding, soldering, shooting range activity on test day) as this may artificially elevate results; allow 48 hours after significant occupational exposure if baseline assessment desired

How our test process works!

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