Bone Profile
Profile
6 parameters
Report in 24Hrs
At Home
No Fasting Required
Details
Comprehensive metabolic bone panel.
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Bone & Mineral Health Panel
| Test | Fasting Required | Key Organs | Primary Use |
|---|---|---|---|
| Calcium | Yes (8–10 hrs) | Bones, parathyroid, kidneys | Bone health, nerve/muscle function, calcium balance |
| Phosphorous (Phosphate) | Yes | Bones, kidneys | Works with calcium for bone integrity; energy metabolism |
| Alkaline Phosphatase (ALP) | Yes | Liver, bones | Marker for bone turnover or liver function |
| Albumin | Yes | Liver | Affects total calcium calculation; nutritional/liver status |
| Parathyroid Hormone (PTH) | Yes | Parathyroid glands | Regulates blood calcium/phosphate via bones, kidneys, gut |
| Vitamin D (25-OH) | Yes | Liver (storage) → Kidney (active form) | Calcium/phosphate absorption, bone strength |
Individual Test Detail
- Calcium
(Serum)
- Vital for bone density, muscle contraction, nerve transmission, and blood clotting
- Low Calcium: Hypoparathyroidism, kidney disease, Vitamin D deficiency
- High Calcium: Hyperparathyroidism, cancers, excessive Vitamin D or calcium intake
- Adjusted Calcium = Total Calcium – Albumin adjustment (useful in low albumin states)
- Phosphorous (Inorganic Phosphate)
- Function: Supports bone and teeth strength, helps make ATP (energy molecule)
- Low: Malnutrition, Vitamin D deficiency, alcohol abuse
- High: Kidney failure, hypoparathyroidism
- Alkaline Phosphatase (ALP)
- Bone ALP: Increased during bone growth, fractures, or bone diseases (e.g. Paget’s, rickets)
- Also elevated in liver disorders – always correlate with GGT to differentiate origin
- High in: Bone diseases, liver obstruction, pregnancy (placental ALP)
- Low in: Zinc deficiency, hypothyroidism
- Albumin
- Produced in the liver; low albumin impacts total calcium readings
- Low Albumin: Chronic illness, liver disease, malnutrition
- Used to correct serum calcium: Corrected Ca = Measured Ca + 0.8 × (4.0 − Albumin)
- Parathyroid Hormone (PTH)
- Regulates: Calcium & phosphate via bone resorption, renal reabsorption, and gut absorption (via Vitamin D)
- High PTH (Hyperparathyroidism): High calcium, low phosphate
- Low PTH (Hypoparathyroidism): Low calcium, high phosphate
- Vitamin D (25-Hydroxy)
- Synthesized via sunlight (D3), diet (D2, D3), stored in liver
- Low Vitamin D: Weak bones, muscle pain, fatigue, increased fracture risk
- High Vitamin D: Rare, typically from over-supplementation
- Also test 1,25(OH)₂ D in kidney disease or rare disorders
Diagnostic Use Cases
| Clinical Situation | Likely Abnormalities |
|---|---|
| Osteoporosis/Rickets | ↓ Calcium, ↓ Vitamin D, ↑ ALP, ↑ PTH |
| Hyperparathyroidism | ↑ Calcium, ↓ Phosphate, ↑ PTH |
| Hypoparathyroidism | ↓ Calcium, ↑ Phosphate, ↓ PTH |
| Chronic Kidney Disease (CKD) | ↓ Vitamin D, ↑ Phosphate, ↑ PTH, ↓ Calcium |
| Malnutrition | ↓ Albumin, ↓ Calcium (adjusted), ↓ Phosphate |
Ideal Test Combinations
| Core Panel | Add These For Full Insight |
|---|---|
| Calcium + Phosphorous + ALP | PTH, Vitamin D 25OH, Albumin |
| Bone pain or fractures | Bone density scan (DEXA), X-ray, PTH, Vit D |
| Suspected Parathyroid Disorder | Calcium, Phosphate, PTH, Vit D, eGFR |
| Liver-related ALP | Add GGT, ALT, AST, Bilirubin |
Sample Summary Interpretation
| Pattern | Possible Diagnosis |
|---|---|
| ↑ Calcium + ↑ PTH + ↓ Phosphate | Primary Hyperparathyroidism |
| ↓ Calcium + ↓ PTH + ↑ Phosphate | Hypoparathyroidism |
| ↓ Calcium + ↑ PTH + ↓ Vit D | Vitamin D Deficiency |
| ↑ ALP + Normal Ca/Phos | Bone growth (children) or healing bone |
| ↑ ALP + ↑ GGT | Liver origin rather than bone |
How our test process works!
