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Comprehensive Metal Profile

Hormone/ Element

22 parameters

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Report in 12Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Panel of multiple toxic metals.

₹1,999₹2,890

31% OFF

Parameters

  • List of Tests
    • Aluminium
    • Antimony
    • Arsenic
    • Bismuth
    • Cadmium
    • Chromium
    • Cobalt
    • Lead
    • Manganese
    • Mercury
    • Nickel
    • Selenium
    • Silver
    • Thallium
    • Barium
    • Caesium
    • Uranium
    • Strontium
    • Tin
    • Molybdenum
    • Vanadium
    • Beryllium

Comprehensive Metal Profile

  • Why is it done?
    • Detects and measures toxic and potentially harmful heavy metals and trace elements in blood serum, including suspected heavy metal poisoning from occupational, environmental, or accidental exposure
    • Evaluates both toxic metals (lead, mercury, arsenic, cadmium) and essential trace elements (selenium, molybdenum, vanadium) that are required for normal physiological function
    • Used for occupational health screening in workers exposed to industrial metals and environmental toxins
    • Diagnoses acute or chronic metal toxicity presenting with neurological, gastrointestinal, hematologic, or renal symptoms
    • Assists in environmental health investigations and assessments for contaminated water or food sources
    • Evaluates nutritional status and mineral imbalances affecting metabolic function and immune health
    • Monitors efficacy of chelation therapy or metal detoxification treatment
    • Identifies bioaccumulation of toxic metals in chronically exposed individuals or those with impaired metal excretion
  • Normal Range
    • Aluminium: <10 μg/L (less than 10 micrograms per liter) - normal range indicates minimal aluminium body burden
    • Antimony: <0.5 μg/L - levels above this range suggest environmental or occupational exposure
    • Arsenic: <10 μg/L (whole blood) - normal range reflects background exposure from food and water sources
    • Bismuth: <5 μg/L - elevated levels typically only seen with bismuth medication use or intentional exposure
    • Cadmium: <0.5 μg/L (non-smokers); <2 μg/L (smokers) - smoking significantly elevates levels
    • Chromium: 0.2-1.2 μg/L - essential trace element; levels vary based on dietary intake and occupational exposure
    • Cobalt: 0.1-0.3 μg/L - essential trace element; elevated in those with joint prosthetics or occupational exposure
    • Lead: <10 μg/dL (children); <25 μg/dL (adults) - Centers for Disease Control considers <5 μg/dL optimal
    • Manganese: 4-15 μg/L - essential cofactor for enzymatic reactions; varies with dietary intake
    • Mercury: <5 μg/L (whole blood) - levels increase with dental amalgam fillings or fish consumption; elevated with occupational exposure
    • Nickel: 0.5-2.5 μg/L - occupational and environmental exposure influences levels; higher in smokers
    • Selenium: 100-200 μg/L - essential antioxidant; optimal levels support thyroid and immune function
    • Silver: <1 μg/L - elevated levels rare except with occupational exposure or silver supplement use (risk of argyria)
    • Thallium: <0.1 μg/L - highly toxic; any detectable level suggests exposure to this potent neurotoxin
    • Barium: <10 μg/L - normal background levels; elevated in occupational settings (mining, manufacturing)
    • Caesium: <2 μg/L - rare environmental metal; levels variable based on geographic location and dietary sources
    • Uranium: <0.1 μg/L - naturally occurring element; levels higher in certain geographic regions with uranium deposits
    • Strontium: 200-800 μg/L - chemical analog of calcium; levels reflect dietary intake and bone metabolism
    • Tin: 0.3-5 μg/L - food packaging and occupational sources; elevated levels indicate significant exposure
    • Molybdenum: 0.3-1.3 μg/L - essential enzyme cofactor; deficiency rare but can occur with total parenteral nutrition
    • Vanadium: 0.1-0.5 μg/L - trace element with potential metabolic roles; levels influenced by dietary intake
    • Beryllium: <0.5 μg/L - highly toxic industrial metal; any elevation indicates occupational or environmental exposure requiring investigation
  • Interpretation
    • Aluminium - Elevated levels associated with neurotoxicity, Alzheimer's disease risk, and chronic kidney disease in dialysis patients; indicates exposure through occupational settings, cookware, or antacid use
    • Antimony - Elevated levels indicate occupational exposure in mining, smelting, or plastics manufacturing; causes respiratory irritation and cardiac arrhythmias at high levels
    • Arsenic - Elevated levels indicate acute or chronic poisoning; associated with skin lesions, gastrointestinal disease, cancer risk, and increased cardiovascular mortality at >50 μg/L
    • Bismuth - Elevated levels indicate bismuth medication toxicity or intentional exposure; may cause encephalopathy, myoclonus, or black discoloration of oral tissues
    • Cadmium - Elevated levels (>2 μg/L) indicate toxic exposure; causes renal dysfunction, bone demineralization, anemia, and is classified as Group 1 carcinogen
    • Chromium - Elevated levels (>2 μg/L) from occupational exposure; hexavalent chromium (Cr-VI) is carcinogenic and causes respiratory disease; low levels may impair glucose metabolism
    • Cobalt - Elevated levels (>1 μg/L) from occupational exposure or metal-on-metal implants; causes cardiomyopathy (cobalt cardiomyopathy), thyroid disease, and neurological effects
    • Lead - Elevated levels cause dose-dependent neurotoxicity, decreased IQ in children, hypertension, nephropathy, and anemia; no safe threshold identified; occupational exposure is primary source
    • Manganese - Elevated levels (>20 μg/L) from occupational exposure cause manganism (parkinsonism), psychiatric symptoms, and motor dysfunction; low levels may impair bone formation and immune function
    • Mercury - Elevated levels (>10 μg/L) indicate methylmercury or inorganic mercury exposure; causes neurological damage, tremor, personality changes, and renal dysfunction
    • Nickel - Elevated levels (>5 μg/L) from occupational exposure or welding; causes occupational asthma, dermatitis, and is classified as carcinogenic; sensitization occurs with repeated exposure
    • Selenium - Low levels (<70 μg/L) associated with increased cancer risk, hypothyroidism, and reduced antioxidant defense; elevated levels (>250 μg/L) cause selenosis with nail and hair brittleness
    • Silver - Elevated levels associated with argyria (permanent blue-gray skin discoloration) and argyrosis (gray-blue coloration of conjunctiva) from chronic exposure or supplement overuse
    • Thallium - Any detectable level indicates significant exposure to this highly toxic metal; acute poisoning causes gastrointestinal symptoms, hair loss, and acute coronary syndrome
    • Barium - Elevated levels (>50 μg/L) from occupational exposure cause hypertension and hypokalemia through increased cellular potassium uptake; gastrointestinal barium studies are benign
    • Caesium - Elevated levels indicate environmental contamination or radioactive caesium exposure; similar to potassium in metabolism and concentrates in muscle tissue
    • Uranium - Detectable levels indicate occupational, environmental, or accidental exposure; causes renal toxicity and potential radiation exposure (especially with enriched uranium)
    • Strontium - Elevated levels interfere with calcium absorption and bone metabolism; high intake associated with increased fracture risk despite improved bone density
    • Tin - Elevated levels from food packaging or occupational exposure; typically causes minimal acute toxicity but neurological effects reported at very high exposures
    • Molybdenum - Low levels (<0.1 μg/L) rare but may occur with inadequate nutritional intake or total parenteral nutrition; elevated levels generally without clinical significance in serum
    • Vanadium - Elevated levels from occupational exposure or dietary supplementation; associated with irritant respiratory effects and potential metabolic perturbations at high concentrations
    • Beryllium - Any detectable elevation indicates occupational or environmental exposure to this highly toxic metal; causes chronic beryllium disease (sensitization) or berylliosis (inflammatory lung disease)
  • Associated Organs
    • Aluminium - Primary organs: Brain (neurotoxicity), kidneys (accumulation in dialysis patients), bones (interference with calcium metabolism); associated with Alzheimer's disease, dementia, and osteomalacia
    • Antimony - Primary organs: Lungs (respiratory irritation), heart (arrhythmias), gastrointestinal tract (irritation); chronic exposure linked to cardiovascular disease
    • Arsenic - Primary organs: Skin (hyperkeratosis, carcinoma), lungs (cancer, chronic bronchitis), liver (cirrhosis), kidneys (glomerulonephritis), gastrointestinal tract (ulceration); Group 1 carcinogen
    • Bismuth - Primary organs: Brain (encephalopathy), gastrointestinal tract (toxicity), kidneys (nephropathy); causes myoclonus and tremor; black staining of oral mucosa and lips
    • Cadmium - Primary organs: Kidneys (tubular dysfunction, proteinuria), bones (osteoporosis, Itai-itai disease), lungs (emphysema); Group 1 carcinogen affecting multiple organ systems
    • Chromium - Primary organs: Lungs (nasal septum perforation, cancer), kidneys (glomerulonephritis), skin (allergic contact dermatitis); Cr-VI is Group 1 carcinogen
    • Cobalt - Primary organs: Heart (cardiomyopathy, congestive heart failure), thyroid (dysfunction), bone marrow (polycythemia), lungs (interstitial pneumonitis); teratogenic effects possible
    • Lead - Primary organs: Brain (encephalopathy, developmental delays), peripheral nerves (motor neuropathy), kidneys (glomerulosclerosis, chronic kidney disease), bone marrow (microcytic anemia); developmental neurotoxin
    • Manganese - Primary organs: Brain (basal ganglia, manganism), nervous system (parkinsonism, psychiatric disease), liver (accumulation in cholestasis); affects neurotransmitter synthesis and motor control
    • Mercury - Primary organs: Brain (tremor, cognitive decline, emotional lability), kidneys (membranous glomerulonephritis), lungs (interstitial pneumonitis); crosses blood-brain barrier and placenta
    • Nickel - Primary organs: Lungs (asthma, cancer), skin (dermatitis, sensitization), sinuses (carcinoma); Group 1 carcinogen; allergen causing contact hypersensitivity
    • Selenium - Primary organs: Thyroid (selenoprotein synthesis, iodine absorption), immune system (T-cell function), liver (antioxidant defense); deficiency increases viral mutation and cancer risk
    • Silver - Primary organs: Skin (argyria), eyes (argyrosis), liver (accumulation); deposits in tissues irreversible; negligible toxicity but cosmetically significant
    • Thallium - Primary organs: Brain (seizures, psychosis, coma), gastrointestinal tract (hemorrhage, necrosis), peripheral nerves (polyneuropathy); highly toxic; affects multiple organ systems at minimal doses
    • Barium - Primary organs: Heart (hypertension from potassium sequestration), skeletal muscle (hypokalemia-induced paralysis), gastrointestinal tract (spasm); soluble salts more toxic
    • Caesium - Primary organs: Muscle tissue (highest accumulation), kidneys (potential nephrotoxicity), bone marrow; distributes similarly to potassium affecting cellular electrolyte balance
    • Uranium - Primary organs: Kidneys (acute tubular necrosis, chronic nephropathy), liver (accumulation), bone (deposition with radium-like effects); both chemical and radiological toxicity
    • Strontium - Primary organs: Bones (accumulation replacing calcium, impaired osteogenesis), teeth (strontium can replace calcium in enamel), gastrointestinal tract (absorption competing with calcium)
    • Tin - Primary organs: Gastrointestinal tract (irritation from inorganic tin), central nervous system (organotin compounds cause brain damage); food packaging is primary exposure source
    • Molybdenum - Primary organs: Liver (enzyme cofactors for detoxification), kidneys (molybdenum-dependent enzyme function); essential for sulfite oxidase and xanthine oxidase activity
    • Vanadium - Primary organs: Pancreas (glucose metabolism effects), kidneys (potential nephrotoxicity), thyroid (potential interference); potential role in insulin signaling
    • Beryllium - Primary organs: Lungs (chronic beryllium disease, pulmonary fibrosis, lung cancer), immune system (beryllium sensitization with beryllium lymphocyte proliferation test abnormalities); highly carcinogenic
  • Follow-up Tests
    • Aluminium - 24-hour urine aluminium, bone biopsy for aluminium-related bone disease, neuropsychological testing for cognitive effects, serum parathyroid hormone and alkaline phosphatase for bone disease
    • Antimony - Occupational history assessment, occupational hygiene evaluation of workplace exposure, pulmonary function testing if respiratory symptoms present, electrocardiogram for cardiac effects
    • Arsenic - 24-hour urine arsenic (speciated to differentiate organic from inorganic), skin examination, baseline electrocardiogram, liver function tests, renal function assessment, cancer risk counseling
    • Bismuth - 24-hour urine bismuth, assessment for medication-induced toxicity, electroencephalogram if neurological symptoms, renal function tests, gastrointestinal evaluation if GI symptoms
    • Cadmium - 24-hour urine cadmium, renal function assessment (creatinine, cystatin C), urinalysis for proteinuria, bone density assessment (DEXA scan), hemoglobin and hematocrit for anemia
    • Chromium - 24-hour urine chromium, pulmonary function testing, chest X-ray if respiratory symptoms, renal function tests, skin examination for dermatitis, occupational exposure assessment
    • Cobalt - 24-hour urine cobalt, transthoracic echocardiogram for cardiac effects, electrocardiogram, thyroid function tests (TSH, free T4), serum B12 levels, chest X-ray if respiratory involvement
    • Lead - 24-hour urine lead, erythrocyte protoporphyrin or zinc protoporphyrin, blood pressure monitoring, renal function assessment, hemoglobin and hematocrit, occupational exposure source investigation, repeat testing in 3 months
    • Manganese - 24-hour urine manganese, manganese in red blood cells or plasma, MRI of brain for basal ganglia abnormalities, neuropsychological testing for manganism, occupational history and workplace assessment
    • Mercury - 24-hour urine mercury (separated for organic vs inorganic), hair mercury testing, tremor assessment, psychiatric evaluation, neuropsychological testing, renal function tests, repeat monitoring every 1-3 months
    • Nickel - 24-hour urine nickel, pulmonary function testing for occupational asthma, chest X-ray, occupational allergen exposure assessment, nickel patch testing for sensitization, occupational history review
    • Selenium - Plasma glutathione peroxidase activity (functional marker), selenoprotein P levels, thyroid function tests (TSH, free T4), complete blood count for immune function, follow-up testing in 3 months
    • Silver - Ophthalmology examination for argyrosis, dermatology evaluation for argyria severity, phototoxicity testing if sun exposure, assessment of supplementation history, follow-up monitoring in 6 months
    • Thallium - 24-hour urine thallium, activated charcoal gastrointestinal decontamination in acute exposure, intensive supportive care assessment, neurological examination, ophthalmologic examination, toxin source investigation
    • Barium - Serum potassium and electrolytes, electrocardiogram for arrhythmias, blood pressure monitoring, urinalysis for barium sulfate (radiopaque finding), occupational exposure assessment
    • Caesium - Environmental contamination investigation, geographic dietary history assessment, renal function tests, potassium levels and supplementation, radiation exposure assessment if relevant
    • Uranium - Renal function tests (creatinine, BUN), urinalysis, 24-hour urine uranium collection, radiation safety assessment for enriched uranium exposure, occupational health evaluation, toxicology consult
    • Strontium - Serum calcium and phosphate, alkaline phosphatase, parathyroid hormone, vitamin D 25-hydroxy levels, bone turnover markers (P1NP, CTX), DEXA scan for bone density, dietary intake assessment
    • Tin - 24-hour urine tin, gastrointestinal symptoms assessment if inorganic tin exposure, neuropsychological testing if organotin exposure, occupational exposure investigation, food source evaluation
    • Molybdenum - Uric acid levels (xanthine oxidase substrate), sulfite levels (sulfite oxidase substrate), liver function tests, consideration of supplementation if deficiency suspected, metabolic workup if parenteral nutrition
    • Vanadium - Fasting glucose and insulin, glycated hemoglobin if diabetes involvement, thyroid function tests, renal function assessment, occupational exposure history, repeat testing if supplementation history
    • Beryllium - Beryllium lymphocyte proliferation test (BeLPT) for beryllium sensitization, pulmonary function testing, high-resolution CT chest for pulmonary fibrosis, chest X-ray, occupational exposure documentation, immunology consultation
  • Fasting Required?
    • No fasting is required for the Comprehensive Metal Profile; blood can be drawn at any time during the day with no dietary restriction needed
    • Metal levels in blood are not affected by recent food or water intake and remain stable regardless of fasting state
    • Timing considerations: If possible, collect samples in the morning for circadian consistency; timing should be consistent for follow-up monitoring tests to ensure comparability
    • Occupational timing: For occupational exposure assessment, collect samples at end of work shift (post-shift) to capture peak exposure-related levels rather than pre-shift baseline
    • Medications: No medications need to be discontinued specifically for this test; inform lab and physician about all current medications and supplements for interpretation, particularly those containing metals
    • Sample collection: Use metal-free collection tubes (plastic or special metal-free glass); notify phlebotomist of testing to ensure contamination-free collection; avoid EDTA-containing tubes for direct metal testing
    • Environmental precautions: Wash hands thoroughly before blood draw; ensure collection area is clean and free from metal dust or contamination; occupational workers should avoid metal-handling immediately before sample collection if possible
    • Supplementation: Discontinue metal-containing supplements (if advised by physician) 24-48 hours before testing for more accurate baseline assessment of endogenous metal levels; document supplementation history
    • Exposure history: Document recent potential exposures (industrial work, hobbies, consumption of potentially contaminated food or water) at time of testing for accurate clinical correlation

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