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Dengue -IgG (CLIA)

Bacterial/ Viral
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Report in 4Hrs

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At Home

nofastingrequire

No Fasting Required

Details

The Dengue IgG test detects IgG antibodies against the dengue virus, indicating past exposure or secondary infection.

₹399₹660

40% OFF

Dengue - IgG (CLIA) Test Information Guide

  • Why is it done?
    • Detects IgG antibodies against dengue virus to identify past or previous dengue infection
    • Confirms immunity or previous exposure to dengue virus infection
    • Differentiates between acute dengue infection (IgM positive) and past infection (IgG positive)
    • Performed in patients with clinical symptoms suggestive of dengue fever presenting after the first week of illness
    • Useful for epidemiological surveys and determining immune status in endemic areas
    • Helps assess risk of dengue hemorrhagic fever in secondary infections
  • Normal Range
    • Negative Result: < 0.9 Index (Non-Reactive) Indicates no previous dengue infection or insufficient antibody levels
    • Equivocal/Borderline Result: 0.9 - 1.0 Index Result is inconclusive; repeat testing recommended after 3-5 days
    • Positive Result: > 1.0 Index (Reactive) Indicates past dengue infection or immunity to dengue virus
    • Unit of Measurement: Index (Qualitative/Semi-quantitative)
  • Interpretation
    • IgG Negative (Non-Reactive): Patient has not been previously infected with dengue virus or has no detectable antibodies; susceptible to dengue infection
    • IgG Positive with IgM Negative: Past dengue infection with established immunity; indicates recovery from previous dengue episode
    • IgG Positive with IgM Positive: Suggests secondary dengue infection (dengue infection in previously infected individual); higher risk for severe dengue
    • Factors Affecting Results: Timing of blood draw (IgG typically appears 5-10 days after symptom onset and persists for life), cross-reactivity with other flaviviruses (West Nile, Zika), recent dengue vaccination, immunocompromised status
    • Clinical Significance: IgG positivity indicates past exposure and current immunity but does not distinguish between different dengue serotypes; secondary infections carry higher morbidity risk
  • Associated Organs
    • Primary Organ Systems Involved: Lymphatic and immune system; vascular system
    • Dengue Fever (Primary Infection): Self-limited febrile illness with fever, headache, myalgia, arthralgia, and rash; generally resolves within 1-2 weeks
    • Dengue Hemorrhagic Fever (DHF): Occurs primarily with secondary infection; involves thrombocytopenia, bleeding manifestations, capillary leakage
    • Dengue Shock Syndrome (DSS): Severe form with plasma leakage leading to shock, organ failure, and potential mortality
    • Other Associated Complications: Hepatic involvement (elevated transaminases), renal impairment, neurological complications, myocarditis, shock, and multi-organ failure in severe cases
  • Follow-up Tests
    • Dengue IgM (CLIA): Essential to distinguish acute dengue from past infection; appears earlier and is specific for acute infection
    • Dengue RT-PCR (Polymerase Chain Reaction): Most sensitive test for acute dengue; detects viral RNA within first 5 days of illness; identifies dengue serotype
    • Dengue NS1 Antigen Test: Can be positive in acute dengue during the first 9 days; useful when IgM testing is negative but clinical suspicion remains high
    • Complete Blood Count (CBC): Assess for thrombocytopenia, leukopenia, and hemoconcentration; important for monitoring DHF
    • Liver Function Tests (LFTs): Monitor hepatic involvement; elevated transaminases are common in dengue
    • Coagulation Profile (PT/INR, aPTT): Assess bleeding risk in DHF; monitor for disseminated intravascular coagulation (DIC)
    • Repeat IgG Testing: If initial result is equivocal, repeat after 3-5 days for confirmation; seroconversion indicates acute infection
  • Fasting Required?
    • Fasting Required: No
    • Special Instructions: No specific fasting requirements; patient may eat and drink normally before blood collection
    • Medications: No specific medications need to be avoided; continue current medications as prescribed
    • Patient Preparation: Minimal preparation required; inform phlebotomist of current medications and medical history; ensure hydration to facilitate blood collection
    • Specimen Collection Timing: Optimal timing is after day 5 of illness onset for better IgG detection; early testing may require repeat sampling after 3-5 days

How our test process works!

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