Dengue -IgG (CLIA)
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The Dengue IgG test detects IgG antibodies against the dengue virus, indicating past exposure or secondary infection.
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🧪 Dengue – IgG (CLIA)
Test Type: Serology | Method: CLIA (Chemiluminescence Immunoassay)
🧾 What is Dengue IgG?
The Dengue IgG test detects IgG antibodies against the dengue virus, indicating past exposure or secondary infection. It is not used for early diagnosis but rather for confirming previous infection or distinguishing primary vs secondary dengue.
⚗️ What is CLIA?
CLIA (Chemiluminescent Immunoassay) is a high-sensitivity and automated laboratory method that uses a chemiluminescent reaction to detect antibodies or antigens. It’s more accurate and faster than conventional ELISA in many labs.
🎯 Clinical Purpose
Use | Explanation |
|---|---|
Identify past dengue infection | Helps confirm previous exposure to dengue virus |
Distinguish between primary and secondary infection | High IgG levels early in illness indicate secondary dengue |
Aid in diagnosis with other tests | Often done with Dengue NS1 and IgM for full picture |
🔬 When is this test recommended?
- Patient has symptoms suggestive of dengue (fever, body ache, rash)
- When Dengue NS1 or IgM are inconclusive
- In later stages of illness (after 7–10 days of symptom onset)
- For retrospective diagnosis or sero-surveillance
⏱️ Timeline of Antibody Appearance
Antibody | When it appears | What it indicates |
|---|---|---|
IgM | 3–5 days after onset | Recent or primary infection |
IgG | ~7–10 days onward | Past or secondary infection |
🧪 Test Parameters
Aspect | Details |
|---|---|
Sample Type | Serum (blood) |
Fasting Required | ❌ Not required |
Method | CLIA |
Result Format | Qualitative (Positive/Negative) or Semi-Quantitative (Index/COI) |
Turnaround Time | 12–24 hours |
📊 Interpretation of Results
Result | Interpretation |
|---|---|
Negative | No prior dengue infection or too early to detect IgG |
Positive (IgG only) | Past infection or secondary infection |
Positive (IgM + IgG) | Ongoing secondary dengue |
❗ Positive IgG alone does not confirm acute infection — must be interpreted alongside clinical symptoms and other test results (NS1, IgM).
🔗 Recommended Conjunct Tests
Test | Why |
|---|---|
Dengue NS1 Antigen | Detects virus in early phase (0–5 days) |
Dengue IgM | Indicates active or recent primary infection |
CBC | Check for low platelet count and rising hematocrit |
Liver Function Tests | Assess liver stress due to dengue infection |
CRP or ESR | Monitor inflammation and systemic response |
⚠️ Limitations
- Cannot differentiate between past infection and current reinfection by itself.
- May cross-react with antibodies from other flaviviruses (e.g., Zika, West Nile).
- False positives may occur if tested too late in acute illness with only residual IgG.
📍 Summary
Feature | Details |
|---|---|
Marker For | Past dengue infection or secondary dengue |
Method | CLIA (Chemiluminescence Immunoassay) |
When to Use | After day 7 of fever onset, or for seroprevalence |
Complementary Tests | Dengue NS1, Dengue IgM, CBC |
Fasting Required | No |
How our test process works!
