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Dengue IgG IgM NS1(Rapid)

Bacterial/ Viral
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Report in 8Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Detects dengue antibodies & antigen.

₹370₹529

30% OFF

Dengue IgG IgM NS1 (Rapid) Test Information Guide

  • Why is it done?
    • Rapid serological detection of dengue virus infection through simultaneous detection of IgM, IgG, and NS1 antigens
    • IgM detection: Identifies acute/recent dengue infection (typically appears 3-5 days after symptom onset)
    • IgG detection: Indicates past dengue infection or previous dengue exposure with immunity
    • NS1 antigen detection: Identifies early active dengue infection (most sensitive in first 5 days of illness)
    • Primary indication: Diagnosis of suspected dengue fever in endemic areas or travelers returning from dengue-endemic regions
    • Typical timing: Performed during acute phase of illness when presenting with fever, headache, joint pain, rash, or hemorrhagic manifestations
    • Advantages: Rapid results (15-30 minutes), requires small blood sample, simultaneous detection of multiple dengue markers increases diagnostic accuracy
  • Normal Range
    • IgM Result: Negative (Non-reactive) = No recent dengue infection detected
    • IgG Result: Negative (Non-reactive) = No past dengue infection or immunity
    • NS1 Antigen Result: Negative (Non-reactive) = No active early dengue infection
    • Normal Interpretation: All three markers negative indicates no current or past dengue infection
    • Positive Results Indicate:
    • IgM Positive = Acute dengue infection (current or very recent)
    • IgG Positive = Past dengue infection with developed immunity or chronic dengue immunity
    • NS1 Positive = Early active dengue infection (viremia present)
    • Units of Measurement: Qualitative reporting (Positive/Negative or Reactive/Non-reactive)
  • Interpretation
    • Result Pattern Interpretation:
    • IgM(+) IgG(-) NS1(+) or (-): Primary acute dengue infection (first dengue infection)
    • IgM(+) IgG(+) NS1(+) or (-): Secondary dengue infection (reinfection with different serotype)
    • IgM(-) IgG(+) NS1(-): Past dengue infection with immunity (convalescent phase)
    • IgM(-) IgG(-) NS1(+): Very early infection (rare, before antibody response)
    • All Negative: No dengue infection or infection before antibody development (<2 days of symptoms)
    • Clinical Significance:
    • NS1 antigen: Most specific marker for dengue; present during viremia phase (days 0-5 of illness)
    • IgM antibodies: Peak at 1-2 weeks; may persist for 3-6 months
    • IgG antibodies: Appear 3-7 days after infection; persist for life
    • Factors Affecting Results:
    • Timing of test: Earlier tests may show negative results if tested too early (<2-3 days of symptoms)
    • Dengue serotype: Different serotypes may produce varying antibody responses
    • Dengvaxia vaccination: May result in positive IgG; IgM response depends on vaccination timing
    • Immunocompromised status: May affect antibody production and detection
    • Quality of test kit: Sensitivity and specificity vary between manufacturers (typically 85-95%)
    • Limitations: Rapid tests may have lower sensitivity than laboratory-based methods; repeat testing may be needed for confirmatory results
  • Associated Organs
    • Primary Organ Systems Involved:
    • Immune system: Dengue virus triggers innate and adaptive immune response
    • Lymphoid tissues: Viral replication occurs in lymph nodes, spleen, and bone marrow
    • Vascular endothelium: Leads to increased vascular permeability and plasma leakage
    • Blood/Hematologic system: Thrombocytopenia and hemoconcentration common
    • Common Diseases Diagnosed:
    • Dengue Fever: Acute viral illness with fever, headache, myalgia, arthralgia, and rash
    • Dengue Hemorrhagic Fever (DHF): Severe form with platelet count <100,000/μL and hemorrhagic manifestations
    • Dengue Shock Syndrome (DSS): Life-threatening complication with circulatory collapse
    • Severe Dengue: Includes organ dysfunction, plasma leakage, and severe bleeding
    • Potential Complications of Abnormal Results:
    • Thrombocytopenia: Platelet count <100,000/μL increases bleeding risk
    • Plasma leakage: Leads to hypovolemia and shock if severe
    • Hepatomegaly: Liver involvement with potential liver dysfunction
    • Renal involvement: Acute kidney injury in severe cases
    • Myocarditis: Cardiac inflammation and arrhythmias possible
    • Encephalitis: Central nervous system involvement with altered mental status
    • Mortality risk: Case fatality rate 2-5% in dengue hemorrhagic fever without treatment
  • Follow-up Tests
    • Confirmatory Tests:
    • RT-PCR (Reverse Transcription Polymerase Chain Reaction): Gold standard for dengue diagnosis; detects viral RNA
    • ELISA (Enzyme-Linked Immunosorbent Assay): Laboratory-based serological test with higher sensitivity and specificity
    • Dengue Serotype Identification: Determines which dengue strain (DEN1-4) is responsible for infection
    • Hematologic Monitoring Tests:
    • Complete Blood Count (CBC): Monitors platelet count, WBC, hemoglobin, and hematocrit
    • Hematocrit: Serial measurements to detect plasma leakage (>20% rise indicates DHF)
    • Platelet count: Critical indicator; count <100,000/μL warrants close monitoring
    • Biochemical Tests:
    • Liver Function Tests (LFTs): AST, ALT elevations common in dengue; indicates hepatic involvement
    • Coagulation Profile: PT/INR, aPTT to assess bleeding risk
    • Renal Function Tests: Creatinine, BUN to assess kidney function in severe cases
    • Serum Electrolytes: Sodium, potassium for management of fluid imbalance
    • Imaging Studies:
    • Abdominal Ultrasound: Detects ascites, pleural effusion, and hepatomegaly in severe dengue
    • Chest X-ray: Identifies pleural effusion or pulmonary edema
    • Monitoring Frequency:
    • Acute phase: Daily CBC and vital signs monitoring until platelet recovery and clinical improvement
    • Critical phase: 48-72 hours of closest monitoring (highest risk for DHF/DSS)
    • Recovery phase: Daily monitoring until discharge, then follow-up at 1-2 weeks post-discharge
    • Complementary Tests:
    • Tourniquet test: Simple bedside test for dengue susceptibility (not diagnostic)
    • Procalcitonin: Helps differentiate dengue from bacterial infections (typically normal/low in dengue)
  • Fasting Required?
    • Fasting: No, fasting is NOT required for Dengue IgG IgM NS1 (Rapid) test
    • Food and beverage intake: Patient can eat and drink normally before the test
    • Sample Collection Requirements:
    • Sample type: Whole blood (finger prick or venipuncture), plasma, or serum (5-10 mL)
    • Collection time: Can be done at any time of day; no specific timing required
    • Medications:
    • No specific medications need to be avoided prior to this test
    • Continue all routine medications unless specifically advised otherwise by physician
    • Patient Preparation Instructions:
    • Arrive well-hydrated; adequate hydration may facilitate blood collection
    • Wear loose, comfortable clothing that allows easy access to arms for blood draw
    • Inform healthcare provider of any bleeding disorders or medications affecting coagulation
    • For rapid tests: Results typically available within 15-30 minutes
    • Keep sample at appropriate temperature; do not refrigerate for rapid tests

How our test process works!

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