Dengue NS-1 Antigen (Rapid)
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Test for detecting dengue virus (NS1 antigen or IgM antibodies) in suspected dengue fever cases.
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🦟 Dengue NS1 Antigen – Rapid Test
📌 What is NS1?
NS1 (Non-Structural Protein 1) is a viral antigen secreted in blood during the early phase of dengue infection, typically within the first 5 days of illness. Detection of NS1 allows for early diagnosis of dengue before antibodies (IgM/IgG) are produced.
⚙️ Test Overview
Parameter | Details |
|---|---|
Test Name | Dengue NS1 Antigen – Rapid |
Method | Lateral Flow Immunoassay (Rapid Card Test) |
Sample Type | Serum, Plasma, or Whole Blood |
Time to Result | 15–30 minutes |
Fasting Required | ❌ No |
Detection Window | Day 1 to Day 5 of fever |
Use Case | Point-of-care testing, emergency screening |
🧭 When to Use
- Within Day 1–5 of fever onset
- For early clinical suspicion of dengue
- In field settings, rural areas, or low-resource clinics
🔬 Result Interpretation
Result | Interpretation |
|---|---|
Positive | Active dengue infection very likely – early stage |
Negative | No NS1 antigen detected – may be too early or too late for NS1 presence |
🔁 Negative result does not rule out dengue. Consider follow-up with IgM ELISA or PCR based on symptoms and duration.
✅ Advantages
- Fast & easy to perform
- No need for lab infrastructure
- Ideal for mass screening, rural outreach, or urgent triaging
⚠️ Limitations
- Lower sensitivity compared to ELISA/CLIA, especially in secondary infections
- False negatives may occur after Day 5 or due to low viral load
- Should not be used as sole diagnostic tool in complicated cases
🔗 Recommended Additional Tests
Test | Purpose |
|---|---|
CBC (Platelets, Hematocrit) | Assess for thrombocytopenia, plasma leakage |
Dengue IgM / IgG ELISA | Confirm diagnosis in later stages |
Liver Function Test | Detect hepatic involvement (common in dengue) |
Dengue PCR (if available) | Confirm and subtype dengue virus |
CRP / Procalcitonin | Differentiate from bacterial infections |
🧪 Snapshot Table
Feature | Details |
|---|---|
Test Type | Rapid Antigen (Lateral Flow Assay) |
Target Marker | NS1 Antigen (Dengue virus) |
Best Detection Window | Day 1 to Day 5 of fever |
Sample Type | Serum, Plasma, or Whole Blood |
Fasting Required | No |
Result Time | 15–30 minutes |
Sensitivity | Moderate (lower than ELISA/CLIA) |
Utility | Early diagnosis in field/urgent settings |
📌 Summary Decision Tree:
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Patient with Acute Fever
⬇
Day 1–5 of Symptoms?
⬇
YES: NS1 Rapid Test
⬇
┌────────────┬────────────────────┐
│ Positive │ Negative │
│ ⬇ │ ⬇ │
│ Likely │ Do CBC, IgM/IgG │
│ Dengue │ or Dengue PCR │
└────────────┴────────────────────┘
How our test process works!
