Desmoglein I Antibody
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These autoantibodies are associated with autoimmune blistering skin diseases, primarily pemphigus foliaceus.
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🧪 Desmoglein I Antibody Test
🧬 What is Desmoglein I?
Desmoglein I is a cell adhesion protein found in the upper layers of the skin (epidermis). It is a component of desmosomes, structures that help skin cells stick together and maintain skin integrity.
The Desmoglein I antibody test detects autoantibodies directed against Desmoglein I. These autoantibodies are associated with autoimmune blistering skin diseases, primarily pemphigus foliaceus.
🩸 Test Overview
Parameter | Details |
|---|---|
Test Name | Desmoglein I Antibody (IgG) |
Type | Autoantibody blood test |
Sample | Serum (venous blood sample) |
Method | ELISA (Enzyme-Linked Immunosorbent Assay) |
Fasting Required | ❌ No |
Turnaround Time | 5–7 days (may vary by lab) |
Used For | Diagnosis and monitoring of autoimmune skin diseases |
🧭 When is the Test Ordered?
This test is typically ordered when a patient has:
- Blistering or erosive skin lesions
- Crusting, scaling, or redness, especially on the face, scalp, or trunk
- A history of pemphigus or other autoimmune blistering disorders
- To distinguish between pemphigus foliaceus and pemphigus vulgaris
🧪 Interpretation of Results
Result | Indication |
|---|---|
Positive | Suggests presence of Desmoglein I autoantibodies; strong association with pemphigus foliaceus |
Negative | Antibodies not detected; may rule out Desmoglein I-mediated disease, but other forms of pemphigus still possible |
🔄 If Desmoglein III antibodies are also tested and positive, it suggests pemphigus vulgaris.
🧬 Related Autoimmune Diseases
Disease | Autoantibodies Typically Involved |
|---|---|
Pemphigus foliaceus | Anti-Desmoglein I |
Pemphigus vulgaris | Anti-Desmoglein III (± Desmoglein I) |
🧩 Complementary/Confirmatory Tests
Test | Purpose |
|---|---|
Desmoglein III Antibody | Rule out or confirm pemphigus vulgaris |
Skin biopsy with DIF (Direct Immunofluorescence) | Visualize immune deposits in skin lesions |
ANA, ENA Panel | Screen for other autoimmune diseases |
Histopathology of skin lesion | Confirm diagnostic pattern of acantholysis/blistering |
🧾 Summary
Feature | Details |
|---|---|
Disease Focus | Pemphigus foliaceus |
Antigen | Desmoglein I |
Autoantibody Type | IgG |
Test Type | ELISA-based blood test |
Sample | Serum |
Fasting Required | No |
Used for | Diagnosis and monitoring |
How our test process works!
