Eczema Maxi Panel

Allergy

Report in 72Hrs

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No Fasting Required

Details

Allergy panels for eczema triggers.

₹18,500₹26,429

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Eczema Maxi Panel - Comprehensive Guide

Why is it done?
- Comprehensive allergen identification for atopic dermatitis and eczema diagnosis - tests for IgE antibodies against multiple common and uncommon allergens associated with eczema flare-ups
- Identification of specific allergen triggers to guide avoidance strategies and personalized treatment plans for patients with chronic or recurrent eczema
- Differentiation between allergic contact dermatitis, irritant dermatitis, and atopic eczema to determine underlying mechanisms
- Evaluation of patients with persistent eczema unresponsive to standard treatment protocols
- Assessment of occupational or environmental allergen exposure in work-related dermatitis cases
- Typically performed when clinical presentation suggests IgE-mediated allergic component or when multiple allergen sensitivities are suspected
Normal Range
- Negative Results: Class 0 (< 0.35 kU/L per allergen) - indicates absence of IgE antibodies; no sensitization to tested allergens
- Measurement Units: kU/L (kilounits per liter) or kIU/mL (kiloInternational Units per milliliter)
- Classification Scale: Class 0: < 0.35 kU/L (negative); Class 1: 0.35-0.7 kU/L (very weak); Class 2: 0.7-3.5 kU/L (weak); Class 3: 3.5-17.5 kU/L (moderate); Class 4: 17.5-52.5 kU/L (strong); Class 5: 52.5-100 kU/L (very strong); Class 6: > 100 kU/L (extremely high)
- Normal Interpretation: No detectable allergen-specific IgE antibodies; patient likely not sensitized to tested allergens; eczema may be non-allergic or irritant-based
- Abnormal Interpretation: Detectable IgE antibodies (Class 1 or higher) indicate allergic sensitization to specific allergens; higher classes correlate with stronger allergic response potential
Interpretation
- Positive Results (Class 1-6): Indicates IgE-mediated allergic sensitization to one or more allergens; suggests atopic/allergic component to eczema; higher class values indicate stronger sensitization and greater likelihood of clinical symptoms upon exposure
- Multiple Sensitizations: Positive results to multiple allergens suggest polyallergen sensitization typical of atopic dermatitis; indicates more complex allergic profile requiring comprehensive avoidance and management
- Single Allergen Positivity: Positive result to single allergen may suggest contact dermatitis or specific allergen-driven eczema exacerbation; targeted avoidance may be particularly effective
- Class 1-2 (Weak Sensitization): May indicate early sensitization, borderline reactivity, or clinically less significant allergy; may warrant observation before implementing strict avoidance
- Class 4-6 (Strong to Extreme): Indicates clinically significant sensitization with high likelihood of symptom provocation; strict allergen avoidance strongly recommended
- Negative Results: Suggests IgE-mediated allergies are not primary driver; eczema likely from irritant dermatitis, intrinsic/non-allergic atopic dermatitis, or other non-allergic factors; may indicate need for different management approach
- Factors Affecting Results: Recent antihistamine use may suppress skin test reactivity; active dermatitis may elevate baseline IgE; severe immunosuppression may affect IgE production; age affects sensitization patterns; timing of test relative to allergen exposure affects IgE levels
Associated Organs
- Primary System Involved: Integumentary system (skin); immune system (T lymphocytes, IgE-producing B cells, mast cells); lymph nodes involved in immune response
- Atopic Dermatitis/Eczema: Chronic inflammatory skin condition characterized by pruritus, xerosis, and impaired barrier function; associated with IgE-mediated allergies in 50-80% of cases
- Allergic Contact Dermatitis: Type IV hypersensitivity reaction to specific contactants (nickel, fragrances, preservatives, rubber); often presents as localized eczema at contact sites
- Associated Atopic Diseases: Allergic rhinitis, asthma, food allergies, and urticaria frequently co-occur in atopic individuals; represents 'atopic march' or allergic predisposition
- Complications from Untreated Allergic Eczema: Bacterial skin infections (Staphylococcus aureus), severe pruritus affecting sleep and quality of life, lichenification from chronic scratching, psychosocial impact including anxiety and depression, potential systemic infection if severely compromised
- Secondary Effects: Impaired skin barrier function may affect temperature regulation; increased susceptibility to viral infections (eczema herpeticum); risk of systemic absorption of topical medications
Follow-up Tests
- Patch Testing (Epicutaneous Testing): Confirms Type IV hypersensitivity (contact dermatitis); particularly valuable if positive specific allergens require verification or if contact dermatitis is primary concern
- Total IgE Level: Measures overall immunoglobulin E; useful for assessing general atopic tendency and severity of atopic condition; significantly elevated levels support atopic dermatitis diagnosis
- Skin Prick Testing: Rapid in-vivo allergen testing; useful for confirming specific allergen sensitivities identified in serum panel; helps prioritize allergen avoidance strategies
- Eosinophil Count and Eosinophil Cationic Protein (ECP): Measures markers of allergic inflammation; elevated levels correlate with disease severity; useful for monitoring treatment response
- Allergen-Specific IgG4 Levels: May help distinguish active allergy from resolved sensitization; elevated IgG4 relative to IgE may indicate tolerance development or allergen immunotherapy response
- Thyroid Function Tests (TSH, Free T4): When autoimmune component is suspected; thyroid disease commonly associated with atopic dermatitis
- Food-Specific IgE Panel: If food allergy is suspected as eczema trigger; especially important in pediatric cases with systemic symptoms
- Monitoring Frequency: Repeat testing typically not needed unless clinical symptoms change significantly; may retest after 12-24 months if sensitization patterns unclear or if reassessing allergen status after immunotherapy
- Dermatology Referral: Recommended for moderate to severe eczema, failure to respond to standard treatments, or when diagnosis is unclear
- Allergy Specialist Consultation: Particularly valuable for multiple positive results; can develop comprehensive allergen avoidance strategy and consider immunotherapy if appropriate
Fasting Required?
- Fasting Requirement: No - Fasting is NOT required for the Eczema Maxi Panel
- Specimen Collection: Simple blood draw (serum collection) can be performed at any time of day; patient may eat and drink normally before testing
- Medication Considerations: Antihistamines (first and second-generation) should be discontinued 3-5 days prior if skin prick testing will follow; serum testing is not affected by antihistamines; systemic corticosteroids do not significantly affect results
- Special Preparations: Avoid scratching or trauma to skin in antecubital area for 24 hours prior; notify phlebotomist of active skin infections or severe dermatitis affecting venipuncture site; apply ice if needed for pain control but not required
- Pre-Test Instructions: Wear loose, comfortable clothing to facilitate easy blood draw access; bring insurance card and photo ID; no special preparation beyond standard venipuncture precautions required
- Timing Considerations: Best performed during stable disease or 2-4 weeks after acute exacerbation resolves; avoid testing during acute flare-ups when IgE levels may be transiently elevated; results generally stable and do not fluctuate significantly with time of day

How our test process works!