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Estradiol

Reproductive
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Report in 4Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Evaluate menstrual and fertility issues

₹249₹605

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Estradiol Test Information Guide

  • Why is it done?
    • Measures the level of estradiol, the most biologically active form of estrogen hormone in the body
    • Evaluates reproductive health and hormonal balance in both women and men
    • Investigates symptoms of hormonal imbalance including irregular periods, hot flashes, mood changes, and decreased libido
    • Monitors hormone replacement therapy (HRT) and evaluates its effectiveness
    • Assesses fertility issues and ovulation in women; evaluates testicular function in men
    • Investigates symptoms of perimenopause and menopause
    • Evaluates polycystic ovary syndrome (PCOS) and other ovarian disorders
    • Monitors hormone-sensitive cancers such as breast cancer
  • Normal Range
    • Premenopausal Women (Follicular Phase): 15-60 pg/mL (55-220 pmol/L)
    • Premenopausal Women (Ovulatory Peak): 150-750 pg/mL (550-2,750 pmol/L)
    • Premenopausal Women (Luteal Phase): 30-400 pg/mL (110-1,470 pmol/L)
    • Postmenopausal Women: Less than 15-20 pg/mL (less than 55-73 pmol/L)
    • Adult Men: 10-40 pg/mL (37-147 pmol/L)
    • Children (Prepubertal): Less than 10 pg/mL (less than 37 pmol/L)
    • Unit of Measurement: picograms per milliliter (pg/mL) or picomoles per liter (pmol/L)
    • Interpretation: Normal results fall within the reference ranges for age and sex; results outside these ranges may indicate hormone imbalance requiring further evaluation
    • Note: Reference ranges vary by laboratory and may differ based on menstrual cycle phase and sample collection timing
  • Interpretation
    • Elevated Estradiol Levels: May indicate estrogen-secreting tumors, polycystic ovary syndrome (PCOS), liver disease, obesity, excessive hormone replacement therapy, or increased conversion of androgens to estrogen
    • Low Estradiol Levels: May suggest menopause or perimenopause, ovarian failure, hypopituitarism, Turner syndrome, malnutrition, excessive exercise, or inadequate hormone replacement therapy
    • Factors Affecting Results: Menstrual cycle phase (major variation in premenopausal women), time of day, stress levels, medication use (including birth control and HRT), body weight, liver function, and recent pregnancy
    • Clinical Significance in Women: Critical for assessing reproductive function, monitoring fertility treatments, confirming ovulation, diagnosing menopause, and evaluating menopausal symptoms
    • Clinical Significance in Men: Elevated estradiol may indicate hypogonadism, testicular tumors, or liver disease; low levels may reflect testicular failure or hypogonadism
    • Result Pattern Significance: Serial measurements over time provide better clinical information than single results; trends help distinguish normal cycle variation from pathological conditions
  • Associated Organs
    • Primary Organ System: Reproductive system (ovaries in women, testes in men); also involves hypothalamus, pituitary gland, and adrenal glands
    • Associated Diseases: Polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, ovarian cysts, premature ovarian failure, amenorrhea, infertility, hypogonadism, erectile dysfunction, gynecomastia
    • Hormone-Related Conditions: Estrogen-secreting tumors, granulosa cell tumors, hepatocellular carcinoma, adrenocortical tumors, and choriocarcinoma
    • Associated Systemic Diseases: Cirrhosis and chronic liver disease, obesity, hyperthyroidism, systemic lupus erythematosus, and kidney disease
    • Potential Complications of Abnormal Levels: Increased risk of breast cancer and endometrial cancer with elevated estradiol; increased risk of osteoporosis, cardiovascular disease, and cognitive decline with low estradiol
    • Affected Body Systems: Bone health (risk of osteoporosis), cardiovascular system, central nervous system (mood, cognition), breast tissue, and endometrial tissue
  • Follow-up Tests
    • Complementary Hormone Tests: Luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, testosterone, prolactin, thyroid-stimulating hormone (TSH)
    • Reproductive Assessment Tests: Pelvic ultrasound, transvaginal ultrasound, hysterosalpingography, ovarian reserve testing (AMH, antral follicle count)
    • Liver Function Assessment: Liver function tests (AST, ALT, bilirubin, albumin), particularly when elevated estradiol is found
    • Metabolic and Thyroid Evaluation: TSH, free T4, complete metabolic panel to assess overall endocrine and metabolic function
    • Tumor Screening (if indicated): Abdominal imaging (CT or MRI), tumor markers, or endoscopy depending on clinical presentation
    • Monitoring Frequency: If on HRT: every 6-12 months; for fertility evaluation: multiple measurements during menstrual cycle; for cancer monitoring: as recommended by oncologist
    • Bone Health Assessment (if low estradiol): DEXA scan for bone mineral density, calcium and vitamin D levels
    • Cardiovascular Risk Assessment: Lipid panel, blood pressure monitoring, coronary artery calcium scoring if indicated
    • Repeat Testing: Often recommended at specific times in menstrual cycle for premenopausal women; usually performed fasting and in the morning for consistency
  • Fasting Required?
    • Fasting Requirement: No, fasting is not required for the estradiol test
    • Timing of Sample Collection: For premenopausal women: test should be drawn during specific menstrual cycle phases for meaningful results (often 7 days after ovulation in luteal phase, or day 3 of cycle in follicular phase); Morning sample collection preferred between 7-10 AM for consistency
    • Pre-test Medications to Avoid: Do not discontinue hormone replacement therapy, oral contraceptives, or other hormonal medications unless specifically instructed by physician; inform laboratory of all medications being taken
    • Patient Preparation Instructions: Normal diet and fluid intake is allowed; maintain regular sleep schedule; avoid strenuous exercise 24 hours before test; minimize stress if possible
    • What to Bring: Valid ID, insurance information, list of current medications and supplements, and information about last menstrual period (for premenopausal women)
    • Special Considerations: Estradiol levels naturally fluctuate throughout the menstrual cycle; multiple samples may be needed; hormonal birth control may affect results; HRT status must be documented
    • Test Duration: Blood draw takes approximately 5-10 minutes; results typically available within 24-48 hours

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