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FHI360
Blood
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No Fasting Required
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Specialized global health panel (context-specific).
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FHI360 Test Information Guide
- Why is it done?
- FHI360 (also known as Fasting Hepatic Insulin Index or similar metabolic markers) is performed to assess hepatic function and insulin metabolism in fasting states
- Used to evaluate insulin resistance and liver function abnormalities
- Ordered when evaluating metabolic syndrome, diabetes risk assessment, and hepatic function impairment
- Typically performed in fasting state (8-12 hours) for baseline metabolic assessment
- May be part of comprehensive metabolic panels during routine health screening or specific disease evaluation
- Normal Range
- Normal range values vary by laboratory and methodology; reference ranges typically provided on laboratory reports
- Fasting insulin levels: 2-25 mIU/L (may vary by laboratory)
- Liver function markers within normal hepatic ranges indicate no impairment
- Results interpreted as: Normal (negative) - values within reference range; Abnormal (positive) - values elevated or decreased beyond reference range
- Units of measurement: mIU/L (milliiernational units per liter) for insulin, standard hepatic enzyme units for liver function markers
- Interpretation
- Elevated fasting insulin indicates insulin resistance; associated with metabolic syndrome and increased diabetes risk
- Low fasting insulin may suggest pancreatic dysfunction or reduced insulin secretory capacity
- Abnormal liver function markers may indicate hepatic steatosis, cirrhosis, hepatitis, or other liver diseases
- Combined abnormalities suggest metabolic dysfunction affecting both hepatic and endocrine systems
- Factors affecting readings: fasting duration, time of day, recent medication use, stress levels, obesity, physical activity levels
- HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index may be calculated using fasting glucose and insulin to quantify insulin resistance severity
- Associated Organs
- Primary organ systems: Pancreas (insulin production and secretion) and Liver (metabolic function and enzyme production)
- Associated conditions: Type 2 diabetes mellitus, metabolic syndrome, obesity, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS)
- Hepatic diseases detected: cirrhosis, chronic hepatitis, liver fibrosis, alcohol-related liver disease, autoimmune hepatitis
- Endocrine complications: insulin resistance progression leading to type 2 diabetes, gestational diabetes during pregnancy
- Cardiovascular risks associated with insulin resistance and metabolic dysfunction
- Potential complications: progression to end-stage liver disease, acute metabolic decompensation, increased infection risk with hepatic dysfunction
- Follow-up Tests
- Fasting glucose test: assess glucose homeostasis and diabetes risk; performed simultaneously with insulin measurement
- Hemoglobin A1C: evaluate long-term glucose control and diabetes diagnosis over 3-month period
- Oral glucose tolerance test (OGTT): measure glucose response to standardized glucose load; assess prediabetes or diabetes
- Liver function panel: comprehensive assessment of hepatic function including ALT, AST, bilirubin, albumin, alkaline phosphatase
- Lipid panel: evaluate cholesterol and triglycerides; often abnormal with insulin resistance
- Ultrasound or MRI of liver: assess for hepatic steatosis, cirrhosis, or structural abnormalities if liver enzymes abnormal
- C-peptide level: assess pancreatic beta cell function if insulin levels significantly abnormal
- Prothrombin time (PT)/INR: assess coagulation and hepatic synthetic function if severe liver dysfunction suspected
- Monitoring frequency: annual screening for at-risk individuals; more frequent testing (3-6 months) for diagnosed metabolic disorders or liver disease
- Viral hepatitis serology: if liver enzymes abnormal and etiology uncertain; screen for hepatitis A, B, C
- Fasting Required?
- Fasting required: YES
- Fasting duration: 8-12 hours overnight fasting optimal for accurate insulin measurement
- Special instructions: No food, beverages other than water, or supplements during fasting period
- Medications: Consult with healthcare provider; many medications should be taken after blood draw or withheld per physician discretion (insulin, hypoglycemic agents, steroids may need adjustment)
- Avoid: Alcohol consumption 24 hours before test (affects liver function); strenuous exercise day of testing
- Patient preparation: Arrive in morning (8-10 AM preferred); blood draw should occur at same time on subsequent tests for consistency
- Other requirements: Maintain stable weight and diet pattern for 2-3 days before test; inform phlebotomist of current medications; stress reduction recommended
How our test process works!
