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Food Allergen - Gluten, Serum
Allergy
Report in 48Hrs
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No Fasting Required
Details
Antibody test for gluten sensitivity.
₹1,628₹2,326
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Food Allergen - Gluten, Serum Test Information Guide
- Why is it done?
- Detects IgE antibodies against gluten proteins to identify potential IgE-mediated gluten allergies
- Distinguishes between true IgE-mediated gluten allergy and celiac disease or non-celiac gluten sensitivity
- Evaluates symptoms occurring within minutes to 2 hours after gluten ingestion, such as urticaria, angioedema, or anaphylaxis
- Assists in diagnosis of IgE-mediated wheat allergy in patients with acute allergic reactions
- Performed when skin prick testing is contraindicated or inconclusive
- Ordered during acute allergic reactions or when clinically suspected gluten allergy requires confirmation
- Normal Range
- Reference Range: < 0.10 kU/L (kilounits per liter) or < 0.10 IU/mL Interpretation:
- Negative/Normal: < 0.10 kU/L indicates absence of IgE antibodies against gluten; low probability of IgE-mediated gluten allergy
- Positive/Abnormal: ≥ 0.10 kU/L indicates presence of specific IgE antibodies against gluten proteins
- Interpretation levels for positive results: 0.10-0.34 kU/L: Low level IgE antibodies 0.35-0.69 kU/L: Moderate level IgE antibodies 0.70-3.49 kU/L: High level IgE antibodies 3.50-17.49 kU/L: Very high level IgE antibodies ≥ 17.50 kU/L: Extremely high level IgE antibodies
- Units of Measurement: kU/L (kilounits per liter); also expressed as IU/mL or mg/mL
- Clinical Significance: Normal results suggest no IgE-mediated gluten allergy; abnormal results correlate with allergic sensitization but do not confirm clinical allergy; must be interpreted with clinical symptoms
- Interpretation
- Negative Results (< 0.10 kU/L): IgE-mediated gluten allergy is unlikely; however, non-IgE mediated reactions (celiac disease, gluten sensitivity) are not excluded
- Borderline Results (0.10-0.34 kU/L): Low-level sensitization; clinical correlation essential; may indicate early sensitization or weak allergic response
- Mildly Positive Results (0.35-0.69 kU/L): Moderate level of specific IgE; consistent with gluten allergy in symptomatic patients
- Moderately to Highly Positive Results (≥ 0.70 kU/L): Strong evidence of IgE-mediated gluten allergy; higher values correlate with greater likelihood of allergic reactions
- Factors Affecting Results:
- • Timing of test relative to allergen exposure affects IgE levels • Antihistamine use may suppress IgE response • Recent severe allergic reaction may elevate results • Previous immunotherapy or tolerance development may lower levels • Cross-reactivity with other proteins may produce false-positive results • Age and genetic predisposition influence IgE production • Concurrent infections or immune system conditions may affect test accuracy
- Clinical Significance: Results must correlate with clinical history; positive results indicate sensitization but do not prove clinical allergy; negative results do not exclude allergy if clinical symptoms are present; higher titers predict more severe reactions
- Associated Organs
- Primary Organ Systems Involved:
- • Gastrointestinal tract: oral allergy syndrome, angioedema of lips/tongue, nausea, vomiting, diarrhea, abdominal pain • Skin: urticaria (hives), pruritus (itching), angioedema • Respiratory system: rhinitis, laryngeal edema, bronchospasm, asthma exacerbation • Cardiovascular system: hypotension, anaphylaxis • Immune system: mast cell and basophil degranulation, IgE-mediated inflammatory response
- Medical Conditions Associated with Abnormal Results:
- • IgE-mediated wheat/gluten allergy • Allergic rhinitis (hay fever) • Allergic asthma • Atopic dermatitis (eczema) • Food-dependent exercise-induced anaphylaxis (FDEIA) • Oral allergy syndrome • Atopic syndrome (tendency toward multiple allergies)
- Diseases This Test Helps Diagnose:
- • IgE-mediated wheat allergy (distinct from celiac disease) • Anaphylaxis to gluten-containing products • Occupational asthma in bakers (baker's asthma) • Work-related gluten sensitization
- Potential Complications/Risks with Abnormal Results:
- • Anaphylaxis: life-threatening reaction requiring emergency epinephrine administration • Angioedema: severe airway swelling threatening airway patency • Status asthmaticus: severe bronchospasm unresponsive to treatment • Laryngeal edema: potential airway obstruction • Hypotensive shock: severe systemic allergic reaction • Repeated exposures: can sensitize and increase severity of reactions • Accidental ingestion risk: potential for severe reactions with continued gluten exposure
- Follow-up Tests
- Additional Tests Based on Results:
- • Skin Prick Test (SPT) to gluten/wheat: confirmatory testing for IgE-mediated allergy • Total IgE serum level: evaluates overall allergic burden • Tryptase level: measured during acute reactions to assess mast cell degranulation • Thyroid and tissue transglutaminase (tTG-IgA) testing: excludes celiac disease if clinical suspicion exists • Specific IgG4 testing: rules out non-IgE mediated gluten reactions
- Further Investigations:
- • Oral food challenge test: gold standard in controlled medical setting if diagnosis remains uncertain • Elimination diet trial: clinical confirmation by symptom resolution • Upper endoscopy with duodenal biopsy: if celiac disease suspected • Specific component-resolved diagnostics (CRD): tests for individual wheat proteins (omega-5 gliadin, high molecular weight glutenins)
- Monitoring Frequency for Ongoing Conditions:
- • Annual or biennial retesting: for patients on immunotherapy to monitor desensitization • As-needed testing: when clinical symptoms change or new concerns arise • Post-reaction testing: within 24-48 hours to confirm allergy during acute reactions • Follow-up at 1-3 months: after diagnosis confirmation and dietary modification implementation
- Related Complementary Tests:
- • Food Allergen Panel: comprehensive testing for multiple allergens • Milk, egg, peanut, tree nut specific IgE: evaluation for co-existing allergies • Histamine levels: elevated in acute allergic reactions • Complete blood count with differential: identifies eosinophilia in allergic conditions
- Fasting Required?
- Fasting Required: No
- This test does not require fasting; patient may eat and drink normally before blood draw.
- Special Instructions:
- • AVOID antihistamines 3-5 days before test: first-generation antihistamines (diphenhydramine) and second-generation agents (cetirizine, loratadine) suppress IgE response and can produce false-negative results • AVOID topical or systemic corticosteroids 2 weeks before testing: reduces skin reactivity and may affect test accuracy • Continue all other medications as prescribed unless otherwise instructed by physician • Wear loose-fitting clothing for easy blood draw access • Remain hydrated; adequate hydration facilitates easier venipuncture
- Timing Considerations:
- • Optimal timing: 2-6 weeks after allergic reaction for peak IgE levels • During acute reaction: serum testing may be performed immediately • Avoid testing during acute infections or severe immunosuppression: may affect accuracy • May be tested regardless of time of day
- Other Patient Preparation Requirements:
- • No special preparation required beyond discontinuing antihistamines • Patient should inform phlebotomist of recent allergic reactions • Report all current medications and supplements to healthcare provider • Notify staff of vasovagal syncope history or anxiety about blood draws • Single blood draw sufficient for testing (approximately 5-10 mL serum)
How our test process works!
