jamunjar-logo
whatsapp
cartmembermenu
Search for
"test & packages"
"physiotherapy"
"heart"
"lungs"
"diabetes"
"kidney"
"liver"
"cancer"
"thyroid"
"bones"
"fever"
"vitamin"
"iron"
"HTN"

FOOD + INHALANTS ALLERGY SCREENING TESTS (BY IMMUNO- EIA)

Allergy
image

Report in 72Hrs

image

At Home

nofastingrequire

No Fasting Required

Details

Screening panels for allergens.

₹2,960₹4,229

30% OFF

FOOD + INHALANTS ALLERGY SCREENING TESTS (BY IMMUNO-EIA)

  • Why is it done?
    • Detects specific Immunoglobulin E (IgE) antibodies against common food and inhalant allergens using enzyme immunoassay (EIA) technology
    • Identifies allergic sensitization to foods including peanuts, tree nuts, shellfish, fish, eggs, milk, soy, wheat, and sesame
    • Detects sensitization to inhalant allergens such as dust mites, pollen, mold spores, pet dander, and cockroach antigen
    • Ordered when patients present with allergic symptoms including respiratory complaints (sneezing, rhinitis, asthma), skin reactions (urticaria, eczema), gastrointestinal symptoms (abdominal pain, diarrhea), or anaphylactic reactions
    • Performed to distinguish between true IgE-mediated allergies and non-allergic sensitizations or food intolerances
    • Useful for patients with dermatographism or extensive skin conditions where skin prick testing is not feasible
    • Employed in patients requiring continued antihistamine therapy who cannot temporarily discontinue these medications
  • Normal Range
    • Reference Value (Negative Result): < 0.35 kU/L (kilounits per liter) or < 0.35 IU/mL (International Units per milliliter)
    • Unit of Measurement: Serum IgE concentration measured in kU/L or IU/mL
    • Result Interpretation Classification:
    • Class 0 (Negative): < 0.35 kU/L - No IgE antibodies detected, allergen-specific sensitization absent
    • Class 1 (Borderline/Weak positive): 0.35-0.69 kU/L - Minimal sensitization, clinical relevance uncertain
    • Class 2 (Positive): 0.70-3.49 kU/L - Moderate IgE antibody levels, clinical relevance probable
    • Class 3 (Positive): 3.50-17.49 kU/L - Elevated IgE antibody levels, clinical allergy likely
    • Class 4 (Strongly Positive): 17.50-52.49 kU/L - High IgE antibody levels, clinical allergy very likely
    • Class 5 (Very High): 52.50-100 kU/L - Very high IgE antibody levels, strong clinical correlation expected
    • Class 6 (Extremely High): > 100 kU/L - Extremely elevated IgE antibody levels, potent allergen sensitization
    • What Normal Means: Absence of IgE antibodies against tested allergens; no allergic sensitization detected to the specific food or inhalant allergens screened
    • What Abnormal Means: Presence of IgE antibodies indicating allergic sensitization to specific tested allergens; elevated levels correlate with increased probability of clinical allergic reactions upon exposure
  • Interpretation
    • Negative Results (< 0.35 kU/L):
    • No IgE-mediated allergic sensitization to tested allergen; patient is unlikely to experience allergic reaction to that specific allergen
    • Does not completely exclude possibility of non-IgE mediated allergic responses (such as food-protein-induced enterocolitis syndrome or eosinophilic esophagitis)
    • Class 1 Results (0.35-0.69 kU/L):
    • Borderline/weak positive; minimal IgE antibody sensitization; clinical significance uncertain and correlation with symptoms required
    • Requires careful clinical correlation; may represent early sensitization or cross-reactivity
    • Class 2-3 Results (0.70-17.49 kU/L):
    • Positive results indicating moderate to elevated IgE antibodies; clinical allergic reaction probable upon exposure; allergen avoidance should be considered
    • Class 4-6 Results (> 17.50 kU/L):
    • Strongly to very highly positive; high to very high IgE antibody levels; significant risk of severe allergic reaction; strict allergen avoidance strongly recommended
    • Patient may benefit from epinephrine autoinjector prescription and emergency action plan
    • Factors Affecting Test Results:
    • Clinical History and Timing: Recent allergen exposure may temporarily elevate IgE levels; older sensitization may show lower values
    • Immunotherapy Status: Allergen immunotherapy or oral immunotherapy may reduce IgE levels over time
    • Cross-reactivity: Structurally similar allergens may cause false-positive results (e.g., birch pollen cross-reactivity with certain fruits)
    • Medications: Systemic corticosteroids may suppress IgE production; beta-blockers may interfere with treatment if severe reactions occur
    • Age: Atopic individuals typically show higher baseline IgE levels; children may have different reference ranges
    • Laboratory Variation: Different laboratories may use slightly different assays and reference ranges
    • Clinical Significance:
    • Most reliable when combined with detailed clinical history; positive test in absence of clinical symptoms may not require intervention
    • Helps guide dietary modifications and allergen avoidance strategies
    • Useful for identifying triggers in patients with unclear symptom etiology
  • Associated Organs
    • Primary Organ Systems Involved:
    • Respiratory System: Manifestations include allergic rhinitis, nasal congestion, sneezing, postnasal drip, allergic asthma, bronchospasm, wheezing, and shortness of breath
    • Gastrointestinal Tract: Food allergy manifestations include oral allergy syndrome, angioedema of lips/tongue, nausea, vomiting, abdominal cramping, diarrhea, and malabsorption
    • Integumentary System: Skin manifestations include acute urticaria (hives), angioedema, pruritus (itching), erythema, and eczema exacerbation
    • Immune System: IgE-mediated allergic cascade involving mast cells and basophils; involved in allergic inflammation and sensitization mechanisms
    • Cardiovascular System: In severe anaphylaxis, hypotension, tachycardia, arrhythmias, and cardiovascular collapse can occur
    • Medical Conditions Associated with Abnormal Results:
    • IgE-Mediated Food Allergies: Peanut allergy, tree nut allergies, shellfish allergy, fish allergy, milk allergy, egg allergy, soy allergy, wheat allergy
    • Allergic Rhinitis: Chronic or seasonal nasal inflammation triggered by inhalant allergens including pollen, dust mites, mold, and pet dander
    • Allergic Asthma: Reactive airway disease triggered by environmental allergen exposure; can lead to acute exacerbations
    • Atopic Dermatitis: Chronic inflammatory skin condition; often associated with elevated food and inhalant allergen sensitization
    • Allergic Conjunctivitis: Ocular allergy symptoms including itching, watery eyes, redness, and swelling
    • Anaphylaxis: Life-threatening IgE-mediated reaction with rapid onset; high IgE levels predict greater severity risk
    • Atopic Syndrome: Cluster of allergic conditions including asthma, rhinitis, and dermatitis often occurring together
    • Potential Complications of Abnormal Results:
    • Severe Food Allergy Reactions: Risk of angioedema, anaphylaxis with shock, or fatal allergic reactions
    • Chronic Respiratory Complications: Persistent asthma, chronic obstructive patterns, or pulmonary remodeling from repeated inflammatory episodes
    • Secondary Infections: Allergic inflammation impairs barrier function increasing susceptibility to bacterial or fungal infections
    • Nutritional Deficiencies: Excessive food avoidance due to multiple allergies may lead to nutrient deficiency states
    • Psychological Impact: Anxiety regarding accidental exposure, social limitations, reduced quality of life
  • Follow-up Tests
    • Additional Allergy Testing:
    • Skin Prick Testing (SPT): Confirmatory test for IgE-mediated allergy; directly correlates in vivo skin response with IgE antibodies; should be performed when positive serum results require confirmation
    • Intradermal Testing: For specific inhalant allergens if skin prick testing shows borderline results
    • Component-Resolved Diagnostics (CRD): Identifies sensitization to specific allergenic proteins within a single allergen source; particularly useful for predicting reaction severity
    • Total IgE Measurement: Assesses overall immune dysregulation; elevated total IgE may support atopic diagnosis
    • Diagnostic Tests for Specific Conditions:
    • Oral Food Challenge (OFC): Gold standard for definitive diagnosis of food allergy; performed under medical supervision when diagnosis remains uncertain
    • Double-Blind, Placebo-Controlled Food Challenge (DBPCFC): Research standard for confirming food allergy diagnosis
    • Basophil Activation Test (BAT): Functional test measuring basophil response to allergen exposure; increasingly used as complementary diagnostic test
    • Pulmonary and Respiratory Assessment:
    • Spirometry/Pulmonary Function Tests (PFT): Assess for allergic asthma severity; measure FEV1, FVC, and other obstructive parameters
    • Methacholine Challenge Test: Evaluate airway hyperresponsiveness in suspected allergic asthma when baseline spirometry normal
    • Peak Flow Monitoring: Ongoing assessment of asthma control in patients with positive inhalant allergen sensitization
    • Eosinophil Assessment:
    • Complete Blood Count (CBC) with Differential: Elevated eosinophil count (eosinophilia) may support allergic diagnosis
    • Stool Eosinophil Count: If gastrointestinal eosinophilic disorders suspected
    • Endoscopic Biopsy with Eosinophil Quantification: For evaluation of eosinophilic esophagitis or gastroenteritis when suspected
    • Immunological Assessment:
    • IgG Subclass Testing: May be ordered to assess for potential immunotherapy response or tolerance development
    • IgA Measurement: Rule out selective IgA deficiency which may affect allergy testing interpretation
    • Monitoring Frequency:
    • Initial Positive Results: Consider confirmatory testing within 2-4 weeks
    • Immunotherapy Monitoring: Repeat allergen-specific IgE testing every 6-12 months during active allergen immunotherapy
    • Natural Tolerance Assessment: Consider repeat testing annually in children with food allergies to assess for spontaneous resolution
    • Asthma/Rhinitis Management: Reassess yearly or when symptoms change despite current management
  • Fasting Required?
    • Fasting Requirement: NO - Fasting is NOT required for this test
    • This is a serum IgE antibody test that is not affected by food intake or fasting status
    • Patient Preparation Requirements:
    • Regular diet and hydration: Patients may eat, drink, and maintain normal fluid intake prior to test
    • Timing consideration: Can be performed at any time of day; no special timing restrictions
    • Stress minimization: Stress may temporarily elevate IgE levels; relaxation prior to test collection recommended
    • Medications to Avoid/Manage:
    • Antihistamines: H1-receptor antagonists (e.g., cetirizine, loratadine) do NOT need to be discontinued for serum testing as this measures circulating antibodies not tissue response; however, if confirmatory skin testing planned, antihistamines should be stopped 3-5 days prior
    • Tricyclic Antidepressants: Some tricyclic agents (e.g., amitriptyline) have antihistamine properties; should be discussed with provider if skin testing planned
    • Systemic Corticosteroids: Prolonged use may suppress IgE levels; inform provider of current or recent high-dose corticosteroid therapy
    • Beta-blockers: Do not require withholding but important for provider awareness if anaphylaxis risk present; may interfere with epinephrine treatment
    • Special Instructions:
    • Avoid recent allergen exposure: If possible, try to avoid recent exposure to suspected allergens within 24 hours before testing for accurate results
    • Postpone if acute illness: If acutely ill or having active infection, test may be postponed by provider discretion
    • Arm preparation: Clean but non-sterile area acceptable; no special skin preparation needed
    • Single blood draw: Requires only small volume of blood (approximately 3-5 mL) collected via venipuncture into appropriate serum separator tube
    • Room temperature tolerance: Serum sample stable at room temperature; does not require special transport conditions though immediate refrigeration may be preferred by some laboratories

How our test process works!

customers
customers