FOOD + INHALANTS + NON VEG ALLERGY SCREENING TESTS (BY IMMUNO- EIA)

Allergy

Report in 72Hrs

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No Fasting Required

Details

Screening panels for allergens.

₹3,552₹5,074

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FOOD + INHALANTS + NON VEG ALLERGY SCREENING TESTS (BY IMMUNO-EIA)

Why is it done?
- Detects specific IgE antibodies against common allergens including food proteins (nuts, shellfish, eggs, dairy, wheat), inhalant allergens (pollen, dust mites, animal dander, mold spores), and non-vegetarian proteins
- Identifies type I hypersensitivity reactions and allergic sensitization patterns in individuals
- Diagnoses allergic rhinitis, asthma, atopic dermatitis, food allergies, and anaphylactic reactions
- Performed when patients present with symptoms such as pruritus, urticaria, angioedema, rhinitis, conjunctivitis, asthma, gastrointestinal distress, or anaphylaxis
- Essential in patients with family history of allergies, atopic conditions, or environmental sensitivities
- Safe alternative to skin prick testing, especially in patients with severe dermatitis, on antihistamines, or with high anaphylaxis risk
Normal Range
- Units of Measurement: IU/mL (International Units per milliliter) or kUA/L
- Normal/Negative Result: < 0.35 IU/mL (Class 0) - No detectable specific IgE antibodies; indicates absence of allergic sensitization to tested allergen
- Borderline/Equivocal Result: 0.35 - 0.70 IU/mL (Class 1) - Minimal specific IgE; may indicate early sensitization or clinically insignificant levels
- Positive/Low Grade Result: 0.71 - 3.5 IU/mL (Class 2) - Low specific IgE levels; indicates allergic sensitization with possible clinical relevance
- Positive/Moderate Grade Result: 3.51 - 17.5 IU/mL (Class 3) - Moderate specific IgE levels; likely clinical relevance with probable allergic symptoms on exposure
- Positive/High Grade Result: 17.51 - 52.5 IU/mL (Class 4) - High specific IgE levels; strong allergic sensitization with high probability of clinical symptoms
- Positive/Very High Grade Result: > 52.5 IU/mL (Class 5 or 6) - Very high specific IgE levels; definite allergic sensitization with severe clinical manifestations likely
- Interpretation: Results must be correlated with clinical symptoms and history; positive results indicate IgE-mediated sensitization but do not definitively diagnose clinical allergy without symptom correlation
Interpretation
- Negative Results (< 0.35 IU/mL): No specific IgE antibodies detected; patient is not sensitized to tested allergens; rules out IgE-mediated allergy; symptoms may be due to non-allergic causes (irritants, infections, food intolerance)
- Positive Results (≥ 0.35 IU/mL): Specific IgE antibodies detected; indicates allergic sensitization; higher values correlate with greater sensitization severity and increased likelihood of clinical symptoms on allergen exposure
- Class 1-2 (Borderline to Low): Mild sensitization; clinical symptoms may be absent or minimal; further history and provocative testing may be needed for clinical correlation; consider cross-reactivity with structurally similar allergens
- Class 3-4 (Moderate to High): Significant allergic sensitization; clinical symptoms likely present; patient should avoid or minimize allergen exposure; consider specific immunotherapy or pharmacologic management
- Class 5-6 (Very High): Severe allergic sensitization; strong predictive value for clinical allergy; high anaphylaxis risk especially with food allergens; strict allergen avoidance mandatory; epinephrine auto-injector recommended for food-allergic patients
- Multiple Positive Allergens: Suggests atopic predisposition; patient may be prone to developing new allergies; requires comprehensive environmental and dietary management; consider allergy skin testing for confirmation
- Factors Affecting Results: IgE levels may fluctuate with allergen exposure, immune status, concurrent infections, immunosuppressive therapy, age (IgE typically peaks in childhood), and pregnancy; recent allergen exposure may cause transiently elevated levels
- Clinical Correlation Importance: Results must be interpreted alongside patient's clinical history, timing of symptoms, exposure history, and physical examination; a positive test without clinical symptoms suggests sensitization without clinical allergy; negative test with allergic symptoms suggests non-IgE-mediated mechanism (cell-mediated, food intolerance, irritant response)
Associated Organs
- Primary Organ Systems: Immune system (particularly B lymphocytes and mast cells), respiratory system, gastrointestinal system, integumentary system, and cardiovascular system
- Allergic Rhinitis: Inflammation of nasal mucosa caused by inhalant allergens (pollen, dust mites, animal dander, mold); IgE-mediated response triggers histamine release causing nasal congestion, rhinorrhea, and pruritus
- Allergic Asthma: Bronchial airway inflammation and bronchoconstriction triggered by allergen-specific IgE binding; leads to wheezing, dyspnea, cough, and chest tightness; can progress to severe exacerbations and respiratory failure
- Food Allergy: IgE-mediated reactions to food proteins causing gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain), oral pruritus, angioedema, urticaria, anaphylaxis; primarily affects GI tract but can involve skin and respiratory system
- Atopic Dermatitis: Chronic inflammatory skin condition with elevated IgE and specific IgE to allergens; involves impaired skin barrier and heightened allergic response; exacerbated by allergen exposure and stress
- Anaphylaxis: Severe, life-threatening IgE-mediated reaction affecting multiple organ systems; causes cardiovascular collapse, respiratory distress, GI symptoms, and cutaneous manifestations; requires immediate epinephrine administration
- Urticaria and Angioedema: Acute skin reactions with pruritic wheals (urticaria) or subcutaneous swelling (angioedema); caused by IgE-mediated mast cell and basophil degranulation releasing histamine; usually self-limiting but may indicate severe allergic reaction risk
- Allergic Conjunctivitis: Inflammation of conjunctiva caused by inhalant allergen exposure; manifests with ocular pruritus, tearing, conjunctival injection, and chemosis; usually accompanies allergic rhinitis
- Potential Complications: Chronic allergen exposure may lead to persistent inflammation, tissue remodeling, asthma exacerbations, secondary infections, reduced quality of life, and severe allergic reactions; anaphylaxis carries risk of death if untreated
Follow-up Tests
- Skin Prick Testing (SPT): Confirmatory in vivo test for IgE-mediated allergies; provides rapid results; useful for allergen-specific confirmation and identifies additional unsuspected allergens; contraindicated in severe dermatitis or high anaphylaxis risk
- Oral Food Challenge Test (OFC): Gold standard for food allergy diagnosis; confirms clinical reactivity to specific food allergen; performed under medical supervision due to anaphylaxis risk; useful when serology results uncertain or clinical history unclear
- Component-Resolved Diagnostics (CRD): Tests for IgE to specific allergenic proteins within allergen sources; helps differentiate between true allergy and cross-reactivity; particularly useful for tree nut, shellfish, and seed allergies to assess severity risk
- Total IgE Measurement: Assesses overall allergic status and sensitization burden; helps establish baseline for monitoring treatment response; elevated in atopic individuals and parasitic infections; useful for predicting allergic disease progression
- Pulmonary Function Tests (PFT): Recommended if patient has positive inhalant allergens with respiratory symptoms; assesses airway obstruction severity; establishes baseline for asthma management; helps monitor disease progression and treatment efficacy
- Bronchial Provocation Challenge: Performed with positive inhalant allergens and respiratory symptoms to assess airway hyperresponsiveness; uses methacholine or histamine challenge; confirms allergic asthma diagnosis
- Blood Eosinophil Count: May be elevated in allergic conditions; useful for identifying atopic phenotype; helps assess allergic inflammation burden and guides biologic therapy decisions in severe asthma
- Imaging Studies: Chest X-ray if asthma suspected; sinus CT if chronic rhinosinusitis suspected; helps evaluate structural complications from chronic allergic inflammation
- Allergen Avoidance Trial: Therapeutic trial of strict allergen avoidance; practical confirmation of causative allergen; symptom improvement during avoidance supports allergic diagnosis; helpful when serology-clinical correlation uncertain
- Baseline Monitoring: Repeat testing recommended annually or when new allergic symptoms develop; helps assess for new sensitivizations; useful for monitoring atopic progression in susceptible individuals; can assess treatment response to immunotherapy
Fasting Required?
- Fasting Status: NO - Fasting is not required for this allergen-specific IgE immunoassay
- Blood Collection Preparation: Patient may eat and drink normally before blood draw; no dietary restrictions necessary; samples can be collected at any time of day; routine venipuncture can be performed during any convenient appointment
- Medication Considerations: Antihistamines (H1 and H2 blockers) do NOT significantly interfere with specific IgE detection; patient may continue routine medications including antihistamines, corticosteroids, and bronchodilators without affecting test accuracy; NSAIDs and other systemic medications do not require discontinuation
- Note for Skin Testing Comparison: If skin prick testing is planned as follow-up, antihistamines must be discontinued 3-5 days before testing as they suppress skin responses; patient should inform phlebotomist if skin testing is planned concurrently
- Special Instructions: Patient should be relaxed and seated comfortably for 5-10 minutes before blood draw; avoid strenuous exercise immediately before collection; inform laboratory staff about recent acute infections or immunizations as these may transiently affect results
- Sample Handling: Serum separator or plain blood collection tube typically used; sample should be properly labeled with patient identification and test specifications; refrigerate if delayed testing anticipated; IgE is relatively stable for several days at room temperature or refrigerated

How our test process works!