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Glucose Challenge Test (2hours after 75gm Glucose load)

Unit Test
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Report in 16Hrs

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At Home

fastingrequire

Fasting Required

Details

Measures blood sugar levels to diagnose diabetes

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🧪 What is the Glucose Challenge Test (2-hour post 75g glucose load)?

This test is a single-step oral glucose tolerance test (OGTT) used to screen or diagnose diabetes mellitus and gestational diabetes mellitus (GDM).
It involves measuring blood glucose levels 2 hours after consuming a 75-gram glucose drink.

This is distinct from the Glucose Tolerance Test with multiple readings, as this version takes only the 2-hour post-load value.

❓ Why is the Test Done?

To:

  • Diagnose type 2 diabetes or prediabetes
  • Screen for gestational diabetes (especially in pregnant women)
  • Evaluate glucose intolerance
  • Assess post-prandial glucose handling

📊 Normal Values (2-hour after 75g Glucose)

Patient Type

Glucose (mg/dL)

Interpretation

General population

< 140 mg/dL

Normal glucose tolerance

140–199 mg/dL

Impaired glucose tolerance (Prediabetes)

≥ 200 mg/dL

Diabetes mellitus (confirmed with repeat testing)

Pregnant (GDM screening)

≥ 140 mg/dL

Suggestive of Gestational Diabetes Mellitus (GDM)

🌐 In India, the DIPSI guideline recommends 2-hour 75g glucose test without fasting for GDM screening.

📈 Interpretation of Results

Result

Meaning

<140 mg/dL

Normal

140–199 mg/dL

Impaired Glucose Tolerance (Prediabetes)

≥ 200 mg/dL

Diagnostic of Diabetes (if confirmed)

Pregnant woman ≥ 140 mg/dL

Suggestive of GDM (Gestational Diabetes)

🧠 Associated Organs and Conditions

System

Related Conditions

Endocrine / Pancreas

- Type 2 Diabetes Mellitus
- Gestational Diabetes
- Insulin resistance / Metabolic Syndrome

Placenta (in pregnancy)

- Gestational diabetes-related hormonal interference

Liver / Adipose

- Glucose metabolism disorders, fatty liver, obesity

🔄 Related / Follow-Up Tests

  1. Fasting Blood Sugar (FBS)
  2. HbA1c – Reflects 3-month average glucose
  3. Postprandial Blood Sugar (PPBS)
  4. Insulin & C-peptide levels – Evaluate insulin production
  5. Urine glucose & ketone test – Especially in pregnancy
  6. Lipid profile – Often abnormal in insulin resistance
  7. Repeat OGTT or GTT – If borderline results

✅ Fasting Required?

Situation

Fasting Requirement

Non-pregnant (Diabetes diagnosis)

✅ Yes – Fasting (8–10 hours) required before glucose load

Pregnancy (DIPSI method)

❌ No fasting required – Done in non-fasting state

📝 Summary Table

Parameter

Details

What

Blood glucose test taken 2 hours after 75g oral glucose load

Why

Diagnose diabetes, prediabetes, or gestational diabetes

Normal Range

<140 mg/dL (non-diabetic), <140 mg/dL (GDM screen)

Diabetes Threshold

≥ 200 mg/dL (non-pregnant), ≥ 140 mg/dL (pregnant)

Follow-up Tests

FBS, HbA1c, PPBS, insulin, lipid profile

Fasting Required

✅ Yes (general), ❌ No (pregnancy DIPSI protocol)

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