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H3T Profile

Liver

6 parameters

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Report in 12Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Specialized metabolic/hormonal panels.

₹699₹982

29% OFF

Parameters

  • List of Tests
    • HBsAG
    • TSH
    • Anti Hepatitis C Virus (HCV) - Total
    • HIV - I & II
      • HIV - I & II (IVth Gen)
      • HIV Card
      • HIV (ELISA)

H3T Profile - Comprehensive Medical Test Information Guide

  • Why is it done?
    • The H3T Profile is a comprehensive screening package that simultaneously detects three major infectious diseases (Hepatitis B, Hepatitis C, and HIV) along with thyroid function assessment, making it an essential general health evaluation tool
    • HBsAG (Hepatitis B Surface Antigen): Detects active Hepatitis B infection or immunity status; used for screening blood donors, healthcare workers, pregnant women, and patients with liver disease symptoms
    • TSH (Thyroid Stimulating Hormone): Evaluates thyroid gland function and screens for hypothyroidism and hyperthyroidism; recommended in routine health checkups, especially in patients with fatigue, weight changes, or metabolic concerns
    • Anti-HCV (Anti Hepatitis C Virus - Total): Screens for Hepatitis C antibodies indicating current or past infection; essential for blood bank screening, occupational exposure evaluation, and patients with elevated liver enzymes
    • HIV I & II (Fourth Generation, Card, and ELISA methods): Detects HIV antibodies and antigens; critical for diagnosis, monitoring occupational exposure, pre- and post-exposure prophylaxis evaluation, and general health screening
    • Primary indications include: routine health checkups, pre-employment screening, blood and organ donation assessment, antenatal care, occupational exposure evaluation, and patients presenting with fever, weight loss, or hepatic dysfunction
    • The tests work synergistically to provide comprehensive infectious disease and endocrine screening, enabling early detection and intervention for conditions affecting immune function, liver health, and metabolic regulation
  • Normal Range
    • HBsAG (Hepatitis B Surface Antigen): Negative or Non-Reactive (<0.05 mIU/mL or negative); Positive result indicates Hepatitis B infection or chronic carrier state; Units: mIU/mL (milli-International Units per milliliter) or qualitative negative/positive
    • TSH (Thyroid Stimulating Hormone): Normal Range: 0.4-4.0 mIU/L (may vary slightly between laboratories, typically 0.35-5.5 mIU/L); Units: mIU/L (milli-International Units per Liter); Low TSH (<0.4 mIU/L) suggests hyperthyroidism or thyroid overactivity; High TSH (>4.0 mIU/L) suggests hypothyroidism or insufficient thyroid hormone production
    • Anti-HCV (Anti Hepatitis C Virus - Total): Negative or Non-Reactive (<1.0 index or negative); Positive or Reactive (≥1.0 index or positive) indicates Hepatitis C antibodies present; Units: Index value, S/CO ratio (Sample-to-Cutoff), or qualitative negative/positive
    • HIV I & II (Fourth Generation Antigen/Antibody Test): Negative or Non-Reactive (typically <0.5 S/CO); Positive or Reactive indicates presence of HIV-1 or HIV-2 antibodies and/or antigens; HIV Card/ELISA methods: Negative or Positive results; Units: Qualitative negative/positive, S/CO ratio, or OD (Optical Density) values depending on methodology
    • Borderline or Indeterminate results may require repeat testing or confirmatory testing with alternative methodologies
  • Interpretation
    • HBsAG - Negative Result: No Hepatitis B surface antigen detected; indicates either no Hepatitis B infection or immunity post-vaccination; Positive Result: Indicates active Hepatitis B infection, chronic carrier state, or recent exposure; requires confirmatory testing with HBsAB and HBeAG to determine infection stage and transmissibility; Borderline/Weak Positive: May indicate early infection or recovery phase; repeat testing recommended
    • TSH - Low TSH (<0.4 mIU/L): Suggests primary hyperthyroidism (Graves' disease, toxic nodule), central hypothyroidism, or excessive thyroid hormone replacement; presents with symptoms of increased metabolism; High TSH (>4.0 mIU/L): Indicates primary hypothyroidism where thyroid gland fails to produce adequate hormones; pituitary compensates by increasing TSH; normal TSH with abnormal free T4 suggests secondary thyroid dysfunction; TSH trending upward or downward requires clinical correlation with patient symptoms
    • Anti-HCV - Negative Result: No Hepatitis C antibodies detected; indicates no current or past HCV infection or may represent very early infection (window period, typically first 4-10 weeks); Positive Result: Indicates current or past Hepatitis C infection; presence of antibodies may persist lifelong even after cure; approximately 15-25% of infected individuals spontaneously clear virus; confirmatory testing with HCV RNA PCR needed to differentiate active infection from past exposure; S/CO ratio interpretation: values closer to cutoff warrant repeat testing
    • HIV I & II Fourth Generation - Negative Result: No HIV antibodies or p24 antigen detected; likely not infected, though window period of 18-45 days from exposure should be considered; Positive Result: Indicates HIV infection (Type 1 or Type 2); requires confirmatory testing with Western blot or HIV-1/HIV-2 differentiation immunoassay; Indeterminate Result: Uncommon with fourth generation tests; repeat testing after 1-2 weeks or alternative methodology recommended; window period consideration critical in recent exposure scenarios
    • Factors affecting results: Recent infection (window period affects all tests), immunosuppression may delay antibody development, improper sample collection, hemolysis or contamination, laboratory methodological differences, medications affecting TSH interpretation (beta-blockers, corticosteroids), and pregnancy status affecting hormone levels
    • Serial testing may be recommended for suspicious or borderline results; discordant results between different test methodologies require further investigation and possibly alternative confirmatory tests
  • Associated Organs
    • HBsAG - Primary Organ: Liver; Directly infects hepatocytes causing inflammatory response; Associated diseases: Acute hepatitis B, chronic hepatitis B, cirrhosis, hepatocellular carcinoma (HCC), hepatic fibrosis, and liver failure; Secondary complications involve immune system (immune complex deposition), kidneys (glomerulonephritis), and vascular system (vasculitis); chronic infection increases HCC risk approximately 200-fold; liver biopsy may be needed to assess fibrosis stage
    • TSH - Primary Organ: Thyroid Gland; also involves Pituitary Gland (anterior) and Hypothalamus; TSH controls thyroid hormone (T3 and T4) production regulating metabolism; Associated diseases: Hypothyroidism (Hashimoto's thyroiditis, iodine deficiency, pituitary dysfunction), hyperthyroidism (Graves' disease, toxic nodules, thyroiditis), goiter, thyroid cancer; abnormal TSH affects metabolism, energy levels, body temperature, heart rate, weight management, mental function, and reproductive hormones; subclinical hypothyroidism increases cardiovascular disease risk; affects virtually all organ systems through metabolic regulation
    • Anti-HCV - Primary Organ: Liver; HCV directly infects hepatocytes; Associated diseases: Acute hepatitis C, chronic hepatitis C, cirrhosis, hepatocellular carcinoma, liver fibrosis and steatosis, portal hypertension, and liver failure; extrahepatic manifestations include mixed cryoglobulinemia, membranoproliferative glomerulonephritis, lymphoproliferative disorders, and autoimmune phenomena; chronic infection (70-85% of cases) leads to progressive liver damage; recent curative antiviral therapies available but early detection essential to prevent irreversible damage
    • HIV I & II - Primary Organ System: Immune System (CD4+ T lymphocytes, macrophages, dendritic cells); Associated organs affected: Liver (cirrhosis, hepatitis co-infection), Central Nervous System (encephalitis, dementia), Gastrointestinal tract (opportunistic infections), Lungs (pneumonia), and potentially all organ systems; Associated diseases: AIDS (Acquired Immunodeficiency Syndrome), opportunistic infections (PCP, CMV, TB, candidiasis), malignancies (Kaposi sarcoma, lymphomas), HIV-associated dementia, wasting syndrome, immune reconstitution inflammatory syndrome (IRIS); CD4 count decline correlates with disease progression and opportunistic infection risk; antiretroviral therapy (ART) can restore immune function but requires early diagnosis
  • Follow-up Tests
    • HBsAG Positive - Recommended Follow-up: HBsAb (Hepatitis B surface antibody), HBeAg (Hepatitis B e antigen), HBeAb (Hepatitis B e antibody), HBcAb (Hepatitis B core antibody), HBV DNA quantitative PCR for viral load; Liver function tests (ALT, AST, bilirubin, albumin, alkaline phosphatase); Hepatitis D (Delta) serology if HBsAg positive; Abdominal ultrasound or elastography to assess fibrosis/cirrhosis; Repeat HBsAg testing if weakly positive; vaccination for family contacts; annual surveillance if chronic carrier
    • TSH Abnormal - Recommended Follow-up: Free T4 (thyroxine) level assessment; Free T3 if indicated; Thyroid peroxidase (TPO) and thyroglobulin antibodies for autoimmune thyroiditis; Repeat TSH in 6-8 weeks if initiating thyroid hormone therapy; TSH monitoring every 6-12 weeks during dose titration, then annually when stable; Thyroid ultrasound if thyroid nodules suspected; TSH suppression tests if thyroid cancer history; evaluation for pituitary or hypothalamic dysfunction if low TSH with low free T4; assessment for interference from medications or supplements
    • Anti-HCV Positive - Recommended Follow-up: HCV RNA quantitative PCR (gold standard for active infection confirmation); HCV genotyping to guide antiviral therapy selection; Liver function tests (ALT, AST, GGT, bilirubin, albumin); Hepatitis B and HIV co-infection screening (common co-infections); Abdominal imaging (ultrasound or CT) to assess liver cirrhosis stage; FibroScan (transient elastography) or liver biopsy to determine fibrosis grade; Regular monitoring if untreated (ALT every 6-12 months); consultation with hepatologist for treatment options; repeat Anti-HCV is not useful for monitoring treatment response (use RNA PCR instead)
    • HIV Positive - Recommended Follow-up: HIV-1/HIV-2 differentiation test and confirmatory Western blot or HIV-1/HIV-2 differentiation immunoassay (required before diagnosis confirmation); CD4+ T cell count (baseline and periodic monitoring); HIV-1 viral load (RNA PCR) quantitative to assess replication and guide treatment; Resistance testing before initiating antiretroviral therapy; Baseline liver and kidney function tests; Sexually transmitted infection (STI) screening (syphilis, gonorrhea, chlamydia); Tuberculosis (TB) screening (TST or interferon-gamma release assay); Opportunistic infection prophylaxis based on CD4 count; repeat testing at 3, 6, and 12 months if initial test negative but high-risk exposure (window period); annual screening if negative but ongoing risk; CD4 monitoring every 3 months initially, then every 6-12 months when stable on therapy
    • General Recommendations: Repeat H3T screening annually for individuals in occupational risk categories (healthcare workers, emergency responders) or high-risk behavioral patterns; repeat testing 4-12 weeks after potential exposure for individuals with negative baseline but risk factors; post-exposure prophylaxis (PEP) consideration for recent HIV exposure; counseling regarding transmission prevention and lifestyle modifications
  • Fasting Required?
    • HBsAG - Fasting Required: No; can be performed non-fasting; food and beverage intake do not affect test results; can be collected at any time of day
    • TSH - Fasting Required: No; fasting not necessary as TSH levels are not significantly affected by food intake; however, early morning collection is preferred as TSH exhibits circadian rhythm variation (typically lower in afternoon); consistent collection time recommended for serial monitoring; TSH measurement most accurate in early morning (before 10 AM); medications like corticosteroids, beta-blockers, and amiodarone should be noted as they affect results
    • Anti-HCV - Fasting Required: No; can be performed non-fasting; dietary status does not affect antibody detection; can be collected at any time of day without timing restrictions
    • HIV I & II - Fasting Required: No; fasting not necessary as serological tests are not affected by food intake; can be performed non-fasting; collection time does not affect antibody or antigen detection; can be collected at any time convenient for patient
    • Overall H3T Profile - Fasting Status: No fasting required for the complete H3T Profile package; all component tests can be performed on non-fasting blood samples
    • Medication Considerations: Continue all regular medications unless specifically instructed otherwise; medications affecting TSH (beta-blockers, corticosteroids, lithium, interferon-alpha, amiodarone, phenytoin) should be documented; medications do not typically interfere with serological testing for HBsAg, Anti-HCV, or HIV
    • Additional Preparation: No special dietary restrictions; no need to avoid alcohol specifically for testing day; maintain normal hydration; stress management recommended as stress can affect TSH levels; collect blood sample in morning preferred; arm should be relaxed before blood draw; document any acute illness which may temporarily affect results
    • Window Period Consideration: For HIV and Hepatitis screening, if recent exposure suspected (within 4-12 weeks), inform healthcare provider as repeat testing may be necessary after window period closes; initial negative test does not completely exclude infection if exposure very recent

How our test process works!

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