HELICOBACTER PYLORI - IgA (ELISA)
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Detects the presence of IgA antibodies against H. pylori bacteria in the blood using the ELISA (Enzyme-Linked Immunosorbent Assay) method
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🧪 What is Helicobacter pylori – IgA (ELISA)?
The Helicobacter pylori IgA (ELISA) test detects the presence of IgA antibodies against H. pylori bacteria in the blood using the ELISA (Enzyme-Linked Immunosorbent Assay) method.
- H. pylori is a bacterium that infects the stomach lining, often leading to gastritis, peptic ulcers, and sometimes stomach cancer.
- IgA antibodies suggest active or recent mucosal immune response, often indicating an ongoing or recent infection.
❓ Why is the Test Done?
To:
- Detect recent or active H. pylori infection
- Investigate causes of gastric discomfort, chronic gastritis, ulcers
- Monitor post-treatment response
- Complement IgG and stool antigen testing when results are unclear
📊 Normal Range / Reference Values
Result | Interpretation |
|---|---|
Negative | No significant H. pylori IgA antibodies detected (likely uninfected or past infection) |
Positive | IgA antibodies present – suggests active/recent H. pylori infection |
Equivocal | Borderline result – may require retesting or additional methods |
⚠️ Presence of IgA does not always confirm active infection, especially in the elderly or immunocompromised.
📈 Interpretation of Results
Result | Meaning |
|---|---|
Positive IgA | Likely active or recent H. pylori infection (especially if IgG is also positive) |
Negative IgA | No recent infection or successful eradication |
Declining IgA titers | May indicate response to treatment or resolved infection |
🧠 Associated Organs & Conditions
Organ | Conditions |
|---|---|
Stomach / Duodenum | - Chronic gastritis |
Immune System | IgA reflects mucosal immunity (gut-associated immune response) |
🔄 Related / Follow-Up Tests
- H. pylori IgG Antibody (ELISA) – Indicates past exposure or chronic infection
- H. pylori Stool Antigen Test – Detects active infection
- Urea Breath Test (UBT) – Highly accurate for current infection
- Endoscopy with Biopsy and Rapid Urease Test (RUT) – For symptomatic or high-risk patients
- Complete Blood Count (CBC) – To assess for anemia if ulcers are bleeding
- Gastrin levels – If suspecting Zollinger-Ellison syndrome or atrophic gastritis
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
Helicobacter pylori – IgA (ELISA) | ❌ Not required – Can be performed anytime |
📝 Summary Table
Parameter | Details |
|---|---|
What | ELISA test to detect IgA antibodies against Helicobacter pylori |
Why | Diagnose or monitor recent/active gastric infection |
Normal Range | Negative = no significant IgA response |
Positive Result | Indicates likely recent or ongoing infection |
Follow-up Tests | IgG ELISA, stool antigen, urea breath test, endoscopy |
Associated Conditions | Gastritis, ulcers, gastric cancer |
Fasting Required | ❌ No |
How our test process works!
