Herpes Simplex Virus II (HSV)-IgG
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Detects IgG antibodies specific to: HSV-2: Primarily causes genital herpes
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🧪 What is HSV-2 IgG?
HSV-2 IgG is a blood test that detects Immunoglobulin G (IgG) antibodies against Herpes Simplex Virus Type 2.
- These antibodies appear 2–12 weeks after infection and remain in the blood for life.
- A positive result suggests past or latent HSV-2 infection, usually genital herpes.
❓ Why is the Test Done?
To:
- Detect past exposure or infection with genital herpes (HSV-2)
- Screen asymptomatic sexual partners
- Evaluate patients with recurrent genital ulcers
- Assess prenatal transmission risk to neonates
- Help in differentiating HSV-1 from HSV-2 infection for treatment & counseling
📊 Normal Range / Reference Values
Result | Interpretation |
|---|---|
Negative (<0.9 Index) | No prior HSV-2 exposure |
Equivocal (0.9–1.1 Index) | Borderline – retest in 2–4 weeks |
Positive (>1.1 Index) | Evidence of past HSV-2 infection (latent or resolved) |
Units vary by lab (Index, S/CO, etc.). Interpretation thresholds may differ slightly.
📈 Interpretation of Results
Result | Meaning |
|---|---|
HSV-2 IgG Positive | Indicates past exposure to genital herpes (HSV-2) – person is likely a carrier and may shed virus intermittently |
HSV-2 IgG Negative | No previous exposure – susceptible to HSV-2 |
IgG positive, no symptoms | Asymptomatic carrier – still contagious |
IgG positive, symptoms present | Likely recurrent genital herpes outbreaks |
🧠 Associated Organs & Conditions
System | Conditions |
|---|---|
Genital Mucosa | Genital herpes (painful ulcers, blisters) |
Nervous System | HSV-2 meningitis (aseptic meningitis) |
Neonatal | Neonatal herpes (from maternal infection during delivery) |
Urinary/Rectal | Dysuria, proctitis (especially in immunocompromised) |
🔄 Related / Follow-Up Tests
- HSV-2 IgM – May indicate recent infection or reactivation
- HSV-1 IgG – To distinguish between oral vs genital herpes
- HSV DNA PCR (swab) – Detects virus from active lesions
- TORCH panel – If pregnant, to assess fetal risk
- HIV test – HSV-2 infection increases risk of HIV transmission
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
HSV-2 IgG | ❌ Not required – Blood sample can be collected anytime |
📝 Summary Table
Parameter | Description |
|---|---|
What | Detects IgG antibodies to HSV-2, indicating past or latent infection |
Why | Diagnose or screen for genital herpes, especially in sexually active individuals or pregnant women |
Normal Range | Negative (<0.9 Index) |
Positive Result | Indicates past infection; person may still shed virus |
Follow-up Tests | HSV IgM, HSV PCR, TORCH, HIV |
Associated Conditions | Genital herpes, HSV meningitis, neonatal herpes |
Fasting Required | ❌ No |
How our test process works!
