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🧪 What is hs-CRP?

High Sensitivity C-Reactive Protein (hs-CRP) is a blood test that measures very low levels of C-reactive protein, a substance produced by the liver in response to inflammation.

Unlike standard CRP, hs-CRP detects subtle inflammation and is used primarily to assess cardiovascular risk.
It reflects chronic low-grade inflammation that contributes to atherosclerosis.

❓ Why is the Test Done?

To:

Evaluate risk of heart disease or stroke
Detect low-grade systemic inflammation
Monitor inflammation in metabolic syndrome, diabetes, or autoimmune diseases
Supplement cardiac risk stratification with lipid profile, blood pressure, smoking status, etc.

📊 Normal Range / Interpretation

hs-CRP Level (mg/L)	Risk Category
< 1.0	Low risk of cardiovascular disease
1.0 – 3.0	Moderate risk
> 3.0	High risk – significant inflammation and possible cardiovascular risk
> 10.0	Suggests acute inflammation or infection – investigate further

Note: Values may be elevated by infections, trauma, or recent illness – repeat testing after resolution is advised.

📈 Interpretation of Results

< 1 mg/L: Minimal vascular inflammation – low risk for heart disease
1–3 mg/L: Mild inflammation – moderate risk, requires lifestyle/diet monitoring
> 3 mg/L: Significant inflammation – higher risk of heart attack or stroke
> 10 mg/L: Not useful for cardiac risk – may indicate infection, trauma, autoimmune flare

hs-CRP should not be used alone – it complements other risk factors.

🧠 Associated Organs & Conditions

Organ/System	Conditions
Cardiovascular	Atherosclerosis, coronary artery disease, stroke
Liver (CRP production)	CRP is synthesized in the liver in response to IL-6
Metabolic	Diabetes, obesity, metabolic syndrome
Autoimmune	Lupus, rheumatoid arthritis (complementary to CRP/ESR)
Others	Chronic infections, cancers, smoking, high BMI

🔄 Related / Follow-Up Tests

Lipid Profile (Cholesterol, LDL, HDL, Triglycerides)
HbA1c, Fasting Glucose – for diabetes/metabolic risk
Blood Pressure – for total CVD risk assessment
Standard CRP or ESR – if acute infection or inflammation suspected
Cardiac markers (Troponin, NT-proBNP) – if ACS suspected
Liver Function Tests – as CRP is liver-synthesized

✅ Fasting Required?

Test	Fasting Requirement
hs-CRP	✅ Fasting preferred (8–12 hours) to eliminate influence of recent meals, though not strictly mandatory

📝 Summary Table

Parameter	Description
What	Measures low levels of C-Reactive Protein to assess chronic inflammation and cardiovascular risk
Why	To evaluate heart disease risk, detect low-grade inflammation
Normal Range	<1 mg/L (low risk), 1–3 mg/L (moderate), >3 mg/L (high)
High Result	Increased cardiovascular or systemic inflammation risk
Follow-up Tests	Lipid profile, glucose, CRP, ESR, LFTs, cardiac markers
Associated Conditions	Heart disease, diabetes, autoimmune disease, obesity
Fasting Required	✅ Preferred, especially with lipid profile

High Sensitivity C-Reactive Protein (hs- crp)

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