HLAB27
Report in 24Hrs
At Home
Details
HLA-B27 is not a disease but is strongly associated with autoimmune disorders, especially seronegative spondyloarthropathies.
₹799₹1100
27% OFF
1000+ Booked this Test
🧬 What is HLA-B27?
HLA-B27 (Human Leukocyte Antigen B27) is a protein marker found on the surface of white blood cells. It is encoded by a gene on chromosome 6 and is part of the MHC class I complex that plays a key role in immune system function.
- The presence of HLA-B27 increases susceptibility to certain autoimmune and inflammatory disorders.
- It is not a disease by itself but a genetic marker of risk.
🧪 Test Type
- Type: Molecular test – PCR (Polymerase Chain Reaction) or Flow Cytometry
- Sample: Peripheral blood (EDTA tube)
- Turnaround Time: Usually 2–5 working days
❓ Why is the HLA-B27 Test Done?
To:
- Support diagnosis of seronegative spondyloarthropathies
- Investigate chronic inflammatory back pain or joint stiffness
- Evaluate patients with recurrent uveitis
- Assess risk in individuals with family history of autoimmune conditions
📈 Interpretation of Results
Result | Meaning |
|---|---|
Positive | HLA-B27 gene present → higher risk of autoimmune disorders |
Negative | HLA-B27 gene absent → disease less likely, but not ruled out completely |
Around 90–95% of patients with ankylosing spondylitis (AS) are HLA-B27 positive, but only 5–10% of HLA-B27 positive people develop AS.
🧠 Associated Conditions
System | Conditions Strongly Linked to HLA-B27 |
|---|---|
Musculoskeletal | Ankylosing spondylitis, Reactive arthritis (Reiter’s), Psoriatic arthritis (esp. axial), Enteropathic arthritis |
Ocular | Acute anterior uveitis, iritis |
Gastrointestinal | Inflammatory bowel disease (with joint involvement) |
Dermatologic | Psoriasis with arthritis |
🔄 Related / Follow-Up Tests
- ESR / CRP – Inflammatory markers
- MRI / X-Ray of sacroiliac joints – Especially in ankylosing spondylitis
- Rheumatoid Factor (RF), Anti-CCP – To differentiate from rheumatoid arthritis
- ANA – To rule out lupus
- Uveitis work-up – In case of eye involvement
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
HLA-B27 | ❌ Not required |
📝 Summary Table
Parameter | Description |
|---|---|
What | Detects HLA-B27 genetic marker associated with autoimmune diseases |
Why | Supports diagnosis of seronegative spondyloarthropathies and uveitis |
Result Interpretation | Positive = higher disease risk; Negative = lower risk |
Associated Conditions | Ankylosing spondylitis, reactive arthritis, uveitis, IBD-related arthritis |
Follow-up Tests | ESR, CRP, MRI, RF, Anti-CCP, ANA |
Fasting Required | ❌ No |
How our test process works!
