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IGF BP3 Serum

Hormone/ Element
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Report in 48Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Insulin-like growth factor binding protein.

₹4,144₹5,920

30% OFF

IGF BP3 Serum Test Information Guide

  • Why is it done?
    • Test Purpose: Measures serum levels of IGF-BP3, a binding protein that regulates insulin-like growth factor (IGF-1) bioavailability and activity in the bloodstream
    • Assess Growth Disorders: Evaluate growth hormone (GH) deficiency, growth retardation, and abnormal childhood growth patterns
    • Screen for GH Disorders: Initial screening test for growth hormone excess (acromegaly, gigantism) and deficiency
    • Monitor Treatment: Track effectiveness of growth hormone therapy or treatment for GH-related disorders
    • Evaluate Liver Function: Assess hepatic synthetic capacity since the liver is the primary site of IGF-BP3 production
    • Typical Timing: Performed during routine health examinations, when growth abnormalities are suspected, as part of GH stimulation/suppression testing protocols, or during periodic monitoring of endocrine conditions
  • Normal Range
    • Units of Measurement: ng/mL (nanograms per milliliter) or μg/L (micrograms per liter)
    • Reference Range (Age-Dependent): Normal ranges vary significantly by age and sex; typical adult reference ranges are 0.9-3.7 ng/mL, but pediatric values differ substantially
    • Adult Reference Range: Approximately 0.8-3.7 ng/mL (varies by laboratory and assay method)
    • Pediatric Reference Range: Ranges from approximately 1.0-8.0 ng/mL in children and varies by pubertal stage; peak levels typically occur during adolescence
    • Interpretation Categories: Low (below normal range): Suggests GH deficiency, malnutrition, or liver disease     Normal: Indicates adequate GH secretion and normal growth hormone axis function     High (above normal range): May indicate GH excess, acromegaly, or gigantism
    • Laboratory Variation: Reference ranges may differ between laboratories due to different assay methods and reagents; always refer to the specific reference range provided by your testing laboratory
  • Interpretation
    • Low IGF-BP3 Levels: May indicate growth hormone deficiency, malnutrition, chronic liver disease, hyperthyroidism, or systemic illness; in children, suggests impaired growth or developmental delay
    • Normal IGF-BP3 Levels: Typically indicates normal growth hormone secretion, adequate nutritional status, and normal liver synthetic function; excludes GH deficiency with reasonable confidence
    • High IGF-BP3 Levels: May indicate growth hormone excess, acromegaly, gigantism, or polycystic ovary syndrome (PCOS); elevated during puberty and can be seen in insulin resistance
    • Factors Affecting Results: Age (peaks during adolescence), sex, nutritional status, liver function, thyroid status, insulin sensitivity, estrogen levels, physical activity, sleep quality, and acute illness
    • Clinical Significance: IGF-BP3 is more stable than IGF-1 with less diurnal variation, making it a reliable marker for assessing GH status; single measurement is more reliable than IGF-1 alone; used as screening test before more specific GH stimulation/suppression tests
    • Disease Patterns: In GH deficiency: persistently low levels support diagnosis     In acromegaly: elevated levels with normal IGF-1 suggests GH excess     In liver disease: decreased production reflects hepatic dysfunction
  • Associated Organs
    • Primary Organs Involved: Liver (primary site of IGF-BP3 synthesis and secretion), Anterior Pituitary (produces growth hormone that stimulates IGF system), Hypothalamus (regulates GH secretion)
    • Endocrine Disorders: Growth hormone deficiency, acromegaly, gigantism, pituitary tumors, hypothyroidism, hyperthyroidism, diabetes mellitus, polycystic ovary syndrome (PCOS)
    • Growth Disorders: Growth hormone deficiency in children, idiopathic short stature, constitutional growth delay, growth hormone resistance, familial short stature, abnormal growth patterns
    • Liver Diseases: Cirrhosis, chronic hepatitis, fatty liver disease (NAFLD), hepatic fibrosis, liver synthetic dysfunction, portal hypertension
    • Metabolic and Nutritional Disorders: Malnutrition, protein deficiency, anorexia nervosa, obesity, insulin resistance, metabolic syndrome
    • Potential Complications: Untreated GH deficiency may result in short stature, metabolic dysfunction, decreased bone density; GH excess can cause organ enlargement, hypertension, diabetes, arthropathy; delayed diagnosis of pituitary tumors may lead to mass effects and vision loss
  • Follow-up Tests
    • If IGF-BP3 is Low: Serum IGF-1 level, growth hormone stimulation tests (insulin tolerance test, arginine stimulation, glucagon stimulation), thyroid function tests (TSH, free T4), liver function tests (AST, ALT, albumin, total bilirubin), assessment of nutritional status, evaluation for systemic illness
    • If IGF-BP3 is High: Serum IGF-1 level, growth hormone level, growth hormone suppression test (oral glucose tolerance test), fasting insulin and glucose, OGTT for glucose tolerance assessment, MRI of pituitary gland if pituitary tumor suspected, metabolic syndrome screening
    • Complementary Tests: Serum IGF-1 (gold standard for GH status), Growth hormone (GH) measurement, Prolactin level, ACTH and cortisol, TSH and thyroid hormones, complete metabolic panel, bone age assessment in children
    • Imaging Studies: MRI of pituitary and hypothalamus (if pituitary pathology suspected), abdominal ultrasound or CT (if liver disease suspected), skeletal survey in children (for growth assessment)
    • Monitoring Frequency: For GH replacement therapy: every 6-12 months in children, annually in adults; during acromegaly treatment: every 3-6 months initially, then annually once controlled; for liver disease monitoring: every 6-12 months depending on disease severity
    • Related Testing Panels: Complete pituitary hormone panel (GH, IGF-1, IGF-BP3, prolactin, ACTH, TSH), metabolic syndrome screening panel, liver function panel, growth and development assessment in pediatric population
  • Fasting Required?
    • Fasting Status: No - Fasting is NOT required for this test
    • Reason for Non-Fasting: IGF-BP3 levels are not significantly affected by recent food intake; can be measured during fed or fasted state with equivalent accuracy
    • Timing Considerations: Blood draw is best performed in the morning (7-10 AM) when growth hormone levels are relatively stable; maintain consistency in timing for longitudinal comparisons
    • Medication Instructions: No specific medications need to be withheld; however, patients should notify provider of all medications including growth hormone supplements, corticosteroids, sex hormones, and thyroid medications as these may affect results
    • Patient Preparation: Avoid vigorous exercise for 24 hours before test, rest for 5-10 minutes before blood draw, sit or recline to reduce stress-induced fluctuations in hormone levels, remain calm and relaxed during venipuncture
    • Additional Guidelines: Ensure adequate sleep the night before testing, avoid alcohol consumption for 24 hours, maintain normal hydration, inform phlebotomist of any recent illnesses or stressful events; results may be affected by acute stress, fever, or systemic illness

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