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🧪 What is the Insulin – Postprandial (PP) Test?

The Postprandial (PP) Insulin test measures the level of insulin in the blood 2 hours after a meal or a 75g glucose load.

It evaluates how your pancreas responds to a glucose challenge.
Primarily used to assess insulin resistance and beta-cell function.
Usually done alongside Postprandial Glucose (PPG) to assess glucose-insulin dynamics.

❓ Why is the Test Done?

To:

Diagnose insulin resistance and hyperinsulinemia
Evaluate beta-cell function in the pancreas
Assess polycystic ovarian syndrome (PCOS), metabolic syndrome
Investigate hypoglycemia or reactive hypoglycemia
Help in calculating insulin sensitivity indices (e.g., insulin/glucose ratios)

📊 Normal Range

Result	Interpretation
< 50 µIU/mL	Generally considered normal 2 hours after glucose intake or meal
> 60–80 µIU/mL	Suggestive of hyperinsulinemia or insulin resistance

Note: Optimal values may vary by lab and method. Levels depend on the glucose challenge and individual insulin sensitivity.

📈 Interpretation of Results

Insulin PP Level	Possible Meaning
Low	Possible Type 1 diabetes, beta-cell failure, or insulin deficiency
Normal	Adequate insulin response to glucose load
High	Suggests insulin resistance, early Type 2 diabetes, PCOS, metabolic syndrome
Very High (>100 µIU/mL)	Strong indication of severe insulin resistance or hyperinsulinemia

🧠 Associated Organs & Conditions

Organ/System	Associated Conditions
Pancreas	Type 2 diabetes, insulinoma
Endocrine	PCOS, metabolic syndrome, insulin resistance
Others	Obesity, NAFLD, cardiovascular risk

🔄 Related / Follow-Up Tests

✅ Fasting Required?

Test	Fasting Requirement
Insulin PP	✅ Yes – Initial fasting required before glucose load/meal; sample taken 2 hours after eating or after 75g glucose

📝 Summary Table

Parameter	Description
What	Measures insulin 2 hours after food/glucose load
Why	Assess insulin resistance, beta-cell response, and screen for PCOS/diabetes
Normal Range	<50 µIU/mL (2-hour post meal/glucose)
High Result	Suggests insulin resistance, PCOS, or Type 2 diabetes
Low Result	Suggests insulin deficiency or Type 1 diabetes
Follow-up Tests	FBG, PPBS, fasting insulin, HOMA-IR, GTT
Associated Conditions	PCOS, obesity, diabetes, metabolic syndrome
Fasting Required	✅ Yes – fasting before glucose load or standardized meal

Insulin PP