🧪 What is the LE Cell Test?

The LE (Lupus Erythematosus) Cell Test is a microscopic test used to detect the presence of LE cells—a type of neutrophil or macrophage that has engulfed the denatured nucleus of another cell coated with antinuclear antibodies (ANA).

It was historically used as a diagnostic marker for Systemic Lupus Erythematosus (SLE), although now it has largely been replaced by more specific tests like ANA and anti-dsDNA.

❓ Why is the Test Done?

To:

• Aid in the diagnosis of SLE (Systemic Lupus Erythematosus)
• Detect autoimmune activity involving nuclear autoantibodies
• Support clinical findings of lupus in settings where advanced testing is unavailable

It is rarely used today, but may still be performed in some regions or as part of teaching protocols.

🔬 How is the Test Performed?

• A blood sample (usually heparinized whole blood) is incubated and centrifuged.
• The buffy coat (white cell layer) is examined under a microscope.
• LE cells, if present, appear as neutrophils containing homogeneous nuclear material (hematoxylin bodies).

📊 Result Interpretation

🧠 Associated Organs & Conditions

🔄 Related / Follow-Up Tests

• Antinuclear Antibody (ANA) – more sensitive for SLE
• Anti-dsDNA Antibody – highly specific for SLE
• Anti-Smith (Sm) Antibody
• ESR, CRP – markers of inflammation
• Complement C3/C4 – often low in active lupus
• CBC, Urinalysis, Kidney Function Tests – for organ involvement

✅ Fasting Required?

📝 Summary Table