jamunjar-logo
whatsapp
cartmembermenu
Search for
"test & packages"
"physiotherapy"
"heart"
"lungs"
"diabetes"
"kidney"
"liver"
"cancer"
"thyroid"
"bones"
"fever"
"vitamin"
"iron"
"HTN"

Leg ulcer biopsy - Large Biopsy 3-6 cm

Biopsy
image

Report in 288Hrs

image

At Home

nofastingrequire

No Fasting Required

Details

Biopsy of soft tissue or ulcers.

₹666₹951

30% OFF

Leg Ulcer Biopsy - Large Biopsy 3-6 cm

  • Why is it done?
    • To obtain tissue samples from leg ulcers for microscopic examination and diagnosis of underlying pathology
    • To differentiate between various types of leg ulcers including venous, arterial, diabetic, vasculitic, and neoplastic ulcers
    • To evaluate for malignancy, particularly when ulcers have atypical features, irregular borders, raised edges, or fail to heal within expected timeframe
    • To identify infectious agents such as bacteria, fungi, or atypical organisms in chronic or non-healing ulcers
    • To confirm suspected inflammatory or autoimmune conditions affecting the skin and subcutaneous tissues
    • Typically performed when ulcers are refractory to standard treatment, have unusual clinical presentation, or when diagnosis remains unclear after clinical evaluation
  • Normal Range
    • Histological Findings (Normal/Negative Results):
    • No malignant cells - absence of dysplasia or carcinoma
    • Normal epithelial layer with intact basement membrane
    • No significant inflammation or granulation tissue
    • No infectious organisms on special stains or cultures
    • Histology consistent with common benign ulcer types (venous or arterial insufficiency changes)
    • Special Stains (When Performed):
    • Gram stain - negative for significant bacterial colonization
    • Periodic Acid-Schiff (PAS) - negative for fungal organisms
    • Acid-Fast Bacilli (AFB) stain - negative for mycobacterial infection
  • Interpretation
    • Malignancy Detection:
    • Positive for squamous cell carcinoma - indicates malignant transformation, typically at ulcer edges
    • Positive for basal cell carcinoma - suggests sun-damaged skin or chronic sun exposure
    • Positive for melanoma - indicates primary or secondary melanomatous lesion
    • Dysplastic changes without invasive disease - indicates premalignant state requiring monitoring or excision
    • Vascular Etiology:
    • Venous insufficiency pattern - dilated capillaries, fibrosis, hemosiderin deposits indicating chronic venous disease
    • Arterial insufficiency pattern - ischemic changes, minimal inflammation, lipid accumulation in vessel walls
    • Infectious Findings:
    • Positive for fungal elements - indicates mycotic infection (candida, dermatophytes, or endemic fungi)
    • Positive for acid-fast bacilli - suggests tuberculosis, atypical mycobacteria (MAC, M. marinum), or leprosy
    • Positive bacterial culture with heavy colonization - indicates polymicrobial infection or secondary infection
    • Inflammatory/Vasculitic Findings:
    • Vasculitis pattern - immune complex deposition, vessel wall inflammation, leukocytoclasia suggesting autoimmune condition
    • Granulomatous inflammation - suggests sarcoidosis, tuberculosis, or fungal infection
    • Panniculitis - indicates subcutaneous fat inflammation from autoimmune, infectious, or trauma-related causes
    • Other Conditions:
    • Diabetic ulcer pattern - neuropathic changes, hyalinized blood vessels, minimal inflammation
    • Pressure ulcer characteristics - layers showing skin breakdown, possible bone involvement
    • Pyoderma gangrenosum - dense neutrophilic infiltrate without vasculitis or granulomas
  • Associated Organs
    • Primary Organ Systems Involved:
    • Integumentary system (skin and subcutaneous tissue) - direct tissue sampled
    • Vascular system (venous and arterial circulation) - underlying vascular insufficiency
    • Nervous system - neuropathic changes affecting diabetic ulcers
    • Immune system - autoimmune conditions causing ulceration
    • Conditions Commonly Associated with Abnormal Results:
    • Malignancies - squamous cell carcinoma (Marjolin ulcer), basal cell carcinoma, melanoma
    • Chronic venous insufficiency - accounts for 60-80% of leg ulcers
    • Peripheral arterial disease - ischemic ulcers from atherosclerosis
    • Diabetes mellitus - neuropathic ulcers with peripheral vascular disease
    • Vasculitis - polyarteritis nodosa, microscopic polyangiitis, antineutrophil cytoplasmic antibody (ANCA)-associated disease
    • Pyoderma gangrenosum - rapidly progressive necrotic ulcers, often associated with IBD or hematologic malignancy
    • Livedoid vasculopathy - painful ulcers with livedoid rash
    • Tuberculosis - indolent ulcers with granulomatous inflammation
    • Fungal infections - sporotrichosis, blastomycosis, histoplasmosis
    • Pressure ulcers - Stage III-IV with deep tissue involvement
    • Atypical mycobacterial infections - Mycobacterium marinum, MAC in immunocompromised patients
    • Potential Complications of Abnormal Results:
    • If malignancy confirmed - metastatic spread, systemic disease, reduced survival without prompt treatment
    • If serious infection identified - sepsis, systemic dissemination, amputation risk
    • If vasculitis diagnosed - risk of skin necrosis, permanent disfigurement, need for systemic immunosuppression
    • Chronic non-healing ulcers - persistent pain, functional impairment, increased infection risk
  • Follow-up Tests
    • If Malignancy is Diagnosed:
    • Immunohistochemistry (IHC) staining - for tumor classification and prognosis markers
    • Complete skin examination - to identify additional lesions or satellite tumors
    • Imaging studies - CT scan, MRI, or PET scan for staging and metastatic evaluation
    • Lymph node assessment - sentinel lymph node biopsy or lymphoscintigraphy
    • Oncology consultation - for treatment planning (surgery, radiation, chemotherapy)
    • If Infection is Identified:
    • Culture and sensitivity testing - to guide antimicrobial therapy
    • Fungal culture and identification - if fungal elements present
    • Blood cultures - to assess for systemic infection or bacteremia
    • Imaging (ultrasound or MRI) - to evaluate for subcutaneous abscess or osteomyelitis
    • If Vasculitis or Inflammatory Condition Suspected:
    • Serological testing - ANCA panel, antinuclear antibodies (ANA), rheumatoid factor, complement levels
    • Complete blood count (CBC) and comprehensive metabolic panel - assess inflammatory markers
    • Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) - markers of inflammation
    • Immunofluorescence testing - if vasculitis confirmed histologically
    • Rheumatology consultation - for systemic disease evaluation
    • If Vascular Etiology Confirmed:
    • Duplex ultrasonography - to assess venous/arterial flow dynamics
    • Arterial blood pressure measurement (ankle-brachial index, ABI) - in arterial insufficiency
    • Angiography - to define precise vascular anatomy for intervention planning
    • Vascular surgery consultation - for revascularization assessment
    • If Diabetic Ulcer Confirmed:
    • Hemoglobin A1c (HbA1c) - assess long-term glucose control
    • X-ray imaging - to exclude osteomyelitis in diabetic feet
    • Neuropathy assessment - monofilament testing, vibration perception testing
    • Endocrinology consultation - for diabetes optimization
    • General Monitoring for All Cases:
    • Clinical assessment and photography - document healing progress or deterioration
    • Repeat biopsy - if initial biopsy inconclusive or if clinical picture changes significantly
    • Wound culture - obtained with biopsy if active infection suspected, culture results obtained within 48-72 hours
  • Fasting Required?
    • No - fasting is not required for leg ulcer biopsy
    • Medications:
    • Continue all regular medications including oral agents; patient should take medications as scheduled with normal meal
    • Anticoagulants (warfarin) - continue unless specifically instructed otherwise; discuss INR status with provider
    • Antiplatelet agents (aspirin, clopidogrel) - may be continued unless provider specifies otherwise
    • Topical wound treatments - should be cleaned from ulcer area prior to procedure
    • Patient Preparation:
    • Bathe or shower the day of procedure - cleanse ulcer area gently with non-irritating soap and water
    • Remove existing dressings and topical medications from ulcer - allow area to air dry or pat dry with clean cloth
    • Do NOT apply any creams, ointments, or lotions to ulcer area immediately before biopsy
    • Wear loose, comfortable clothing that allows easy access to affected leg - shorts or pants that roll up recommended
    • Arrange for transportation home - procedure is generally performed as outpatient, but patient should not drive if sedation used
    • Notify provider of any skin allergies or sensitivities - particularly to antiseptic agents or local anesthetics
    • Inform provider of bleeding disorders or use of blood-thinning medications before procedure
    • Arrive 10-15 minutes early for registration and consent process
    • Post-Procedure Care:
    • Keep biopsy site clean and dry for 24-48 hours
    • Apply prescribed topical antibiotics and appropriate wound dressings as instructed
    • Elevate affected leg to reduce swelling and promote healing
    • Results typically available within 3-5 business days for routine histology; special stains may take 5-7 days; culture results obtained within 7-14 days depending on organism type

How our test process works!

customers
customers