Leptospira IgG
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Detects IgG antibodies in the blood against Leptospira bacteria, which cause leptospirosis
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🧪 What is Leptospira IgG Test?
The Leptospira IgG test detects IgG antibodies in the blood against Leptospira bacteria, which cause leptospirosis—a zoonotic bacterial infection spread through water or soil contaminated with animal urine.
- IgG antibodies typically appear later in infection (after 7–10 days) and can remain elevated for months to years, indicating past infection or late-stage/ongoing disease.
- It is commonly done via ELISA or IFA (Immunofluorescence assay).
❓ Why is the Test Done?
To:
- Detect past or late-stage leptospiral infection
- Aid diagnosis in patients with fever of unknown origin (PUO), jaundice, renal failure, or hemorrhagic signs
- Evaluate exposure history, especially in endemic regions or occupational risk (farmers, sewage workers, veterinarians)
📊 Normal Range / Reference Values
Result | Interpretation |
|---|---|
Negative | No detectable IgG antibodies |
Positive | Indicates past infection or late-stage active infection |
Rising titers in paired samples (2–4 weeks apart) are more diagnostic than a single IgG measurement.
📈 Interpretation of Results
IgG Result | Meaning |
|---|---|
Negative | No past exposure, very early infection, or immunocompromised status |
Positive only (no IgM) | Past infection or resolved infection |
Positive (with IgM) | Ongoing infection or recent exposure |
Rising titer (2x or 4x increase) | Active or recent infection (stronger evidence) |
🧠 Associated Organs & Conditions
System/Organ | Possible Complications of Leptospirosis |
|---|---|
Kidneys | Acute renal failure (Weil’s disease) |
Liver | Hepatitis, jaundice |
Lungs | Pulmonary hemorrhage, ARDS |
Nervous system | Aseptic meningitis, encephalitis |
Eyes | Uveitis, conjunctival suffusion |
🔄 Related / Follow-Up Tests
- Leptospira IgM – early marker of acute infection
- MAT (Microscopic Agglutination Test) – gold standard serology
- PCR for Leptospira DNA – useful in early phase
- Liver and Kidney Function Tests – for organ damage
- CBC – leukocytosis, thrombocytopenia
- CRP, ESR – inflammatory markers
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
Leptospira IgG | ❌ No fasting required |
📝 Summary Table
Parameter | Details |
|---|---|
What | Detects IgG antibodies to Leptospira (past/late infection) |
Why | Diagnose leptospirosis in later stages or confirm past exposure |
Normal Range | Negative |
Positive Result | Indicates past or ongoing infection |
Follow-up Tests | IgM, PCR, MAT, LFT, KFT, CBC |
Associated Organs | Kidney, liver, lungs, CNS |
Fasting Required | ❌ No |
How our test process works!
