Lipase
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Serum lipase levels are used to diagnose and monitor acute pancreatitis.
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🧪 What is the Lipase Test?
The Lipase test measures the level of lipase enzyme in the blood.
Lipase is a digestive enzyme primarily produced by the pancreas that helps break down fats (lipids) into fatty acids and glycerol.
❓ Why is the Test Done?
To:
- Diagnose acute or chronic pancreatitis
- Monitor pancreatic function
- Help differentiate abdominal pain due to pancreatic vs. non-pancreatic causes
- Detect other conditions like pancreatic cancer, gallstones, or intestinal obstruction
📊 Normal Range
Parameter | Normal Range |
|---|---|
Lipase | 0–160 U/L (may vary slightly by lab) |
Always interpret in conjunction with amylase, clinical symptoms, and imaging (if needed).
📈 Interpretation of Results
Lipase Level | Possible Meaning |
|---|---|
Normal | Pancreatic function likely normal |
2–5× ULN (Upper Limit of Normal) | Suggestive of acute pancreatitis, especially if sudden abdominal pain present |
Mildly Elevated | Chronic pancreatitis, renal failure, peptic ulcer, celiac disease |
Very High (>5× ULN) | Severe acute pancreatitis, pancreatic necrosis, or duct obstruction |
🧠 Associated Organs & Conditions
Organ/System | Conditions |
|---|---|
Pancreas | Acute/chronic pancreatitis, pancreatic cancer |
Gastrointestinal | Bowel obstruction, peptic ulcer |
Hepatobiliary | Gallstones, biliary obstruction |
Renal | Decreased clearance in kidney failure |
🔄 Related / Follow-Up Tests
- Serum Amylase
- Liver Function Tests (LFT)
- Complete Blood Count (CBC) – to check for inflammation or infection
- Ultrasound or CT scan – for pancreas and gallbladder
- Calcium and Triglycerides – hypercalcemia/hyperlipidemia-related pancreatitis
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
Lipase | ❌ No (not required) |
However, some labs prefer 8–12 hour fasting to improve baseline accuracy, especially if lipids are also being tested.
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures lipase enzyme levels (fat digestion enzyme) |
Why | Diagnose pancreatitis or pancreatic dysfunction |
Normal Range | 0–160 U/L (varies by lab) |
High Values | Pancreatitis, pancreatic cancer, obstruction |
Low/Normal | No active pancreatic issue |
Follow-up Tests | Amylase, LFT, Imaging (USG/CT), CBC, Calcium |
Organs Involved | Pancreas, liver, GI tract |
Fasting Required | ❌ No |
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