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Lymph node biopsy - Medium 1-3 cm

Biopsy
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Report in 288Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Examination of a lymph node (or part of it) to diagnose infections, inflammation, or cancer

₹365₹1,000

64% OFF

Lymph Node Biopsy - Medium 1-3 cm

  • Why is it done?
    • This test measures and analyzes tissue obtained from a lymph node measuring 1-3 cm to detect abnormal cells, infection, or disease presence
    • Diagnose lymphoma and other hematologic malignancies
    • Identify metastatic cancer that has spread to lymph nodes
    • Detect chronic infections including tuberculosis, fungal infections, or atypical mycobacterial infections
    • Evaluate persistent or unexplained lymphadenopathy
    • Assess autoimmune or inflammatory disorders
    • Typically performed when lymph nodes are enlarged, persist beyond 3-4 weeks, or are clinically suspicious for malignancy
  • Normal Range
    • Normal Result: Negative for malignancy, benign lymphoid hyperplasia, or reactive lymphadenopathy
    • Units of Measurement: Histopathologic findings reported as descriptive interpretation; tissue specimen size 1-3 cm
    • Normal Interpretation: Normal lymph node architecture preserved with no evidence of neoplasm, infection, or granulomatous disease
    • Negative Result Indicates: Absence of malignancy, no active infection, normal immune response to previous exposure
    • Positive/Abnormal Result Indicates: Presence of malignant cells, infection, granuloma, or other pathologic process requiring clinical correlation
  • Interpretation
    • Benign Findings: Reactive lymphoid hyperplasia, follicular hyperplasia indicating immune response; suggests no serious underlying pathology
    • Hodgkin Lymphoma: Presence of Reed-Sternberg cells or Hodgkin cells; specific histologic subtypes noted
    • Non-Hodgkin Lymphoma: B-cell or T-cell lymphomas identified; specific subtype diagnosis with immunophenotype reported
    • Infectious Causes: Granulomas suggest tuberculosis or fungal infection; organisms may be identified on special stains
    • Metastatic Disease: Carcinoma, melanoma, or other malignant cells present; tumor type and origin identified by histology and immunostains
    • Factors Affecting Results: Sample adequacy, fixation quality, immunophenotyping availability, presence of sufficient diagnostic material
    • Clinical Significance: Results guide treatment planning, staging of malignancy, identification of infection requiring specific therapy, and prognostic assessment
  • Associated Organs
    • Primary Organ System: Lymphatic system and immune system; specifically evaluates lymph node tissue
    • Associated Conditions - Malignant: Hodgkin lymphoma, non-Hodgkin lymphomas (diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma), chronic lymphocytic leukemia/small lymphocytic lymphoma, metastatic carcinoma, melanoma, and other solid tumors
    • Associated Conditions - Infectious: Tuberculosis, histoplasmosis, coccidioidomycosis, toxoplasmosis, cat-scratch disease, atypical mycobacterial infections
    • Associated Conditions - Inflammatory/Autoimmune: Systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis, Sjögren syndrome
    • Potential Complications from Abnormal Results: Diagnosis of advanced malignancy requiring aggressive treatment, identification of disseminated infection requiring prolonged therapy, staging implications affecting prognosis and treatment planning
    • Biopsy Site Complications: Minimal bleeding, bruising, infection at biopsy site; rarely nerve or blood vessel injury depending on location
  • Follow-up Tests
    • If Malignancy Diagnosed: Flow cytometry, cytochemical stains, cytogenetics, molecular studies (t(15;17), BCR-ABL, t(9;22)), imaging studies (CT, PET scan), bone marrow biopsy for staging
    • If Infection Suspected: Acid-fast bacillus stain, fungal culture, special stains (GMS, PAS), culture and sensitivity, molecular testing (PCR for mycobacteria), tuberculin skin test or interferon-gamma release assay
    • If Inflammatory Disease: Autoimmune serology, serum protein electrophoresis, comprehensive metabolic panel, imaging of affected organ systems
    • Staging and Monitoring: Repeat imaging studies, complete blood count with differential, lactate dehydrogenase, follow-up biopsies as indicated for treatment response assessment
    • Complementary Tests: Immunophenotypic analysis, immunohistochemistry for B-cell and T-cell markers, EBV in-situ hybridization, HHV-8 studies if indicated
    • Monitoring Frequency: Depends on diagnosis; malignancy typically requires frequent follow-up during treatment, then less frequent surveillance; infections may require repeat testing to confirm clearance
  • Fasting Required?
    • Fasting Required: No
    • Patient Preparation: Patient may eat and drink normally; no dietary restrictions required
    • Medication Instructions: Inform physician of anticoagulant use (warfarin, heparin, DOAC); may need to hold antiplatelet agents (aspirin, clopidogrel) 3-5 days prior; continue routine medications unless otherwise instructed
    • Pre-Procedure Requirements: Wear loose, comfortable clothing; mark the biopsy site location; arrive 15 minutes early for paperwork and consent review
    • Special Instructions: Arrange for transportation if sedation will be used; inform about potential side effects of local anesthesia; report allergy to lidocaine or other local anesthetics; discuss any bleeding disorders or anticoagulation therapy
    • Post-Procedure Care: Apply pressure to biopsy site for 10-15 minutes; keep site clean and dry; avoid heavy lifting or strenuous activity for 24-48 hours; monitor for excessive bleeding or signs of infection

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