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Male Infertility Panel

Reproductive

7 parameters

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Report in 8Hrs

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At Home

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No Fasting Required

Details

Male infertility panel.

₹1,499₹2,489

40% OFF

Parameters

  • List of Tests
    • FSH, LH, Prolactin
    • Thyroid Profile - T3, Total T4, TSH
    • Anti Mullerian Hormone (AMH)

Male Infertility Panel

  • Why is it done?
    • The Male Infertility Panel is a comprehensive hormonal assessment designed to identify endocrine causes of male infertility and reproductive dysfunction
    • FSH, LH, and Prolactin evaluate the hypothalamic-pituitary-testicular axis to assess gonadal function, spermatogenesis, and testosterone production
    • Thyroid Profile (T3, Total T4, TSH) detects thyroid dysfunction that can impair sexual function, testosterone metabolism, and sperm production
    • Anti-Mullerian Hormone (AMH) serves as a marker of testicular reserve and Sertoli cell function, indicating the potential for spermatogenesis
    • Ordered in cases of infertility, erectile dysfunction, low libido, abnormal semen analysis, or family history of reproductive disorders
    • Recommended as part of initial evaluation in men with primary or secondary infertility after semen analysis
    • Assists in determining whether infertility is due to hormonal imbalance, thyroid disease, or testicular insufficiency
    • These tests work synergistically to provide a complete endocrine profile that guides treatment decisions and predicts response to interventions
  • Normal Range
    • FSH (Follicle-Stimulating Hormone): 1.7-8.6 mIU/mL (normal ranges indicate normal Sertoli cell function and spermatogenesis)
    • LH (Luteinizing Hormone): 1.7-8.6 mIU/mL (normal levels indicate adequate testosterone stimulation by Leydig cells)
    • Prolactin: 2.0-18.0 ng/mL (normal levels ensure proper testosterone and gonadotropin regulation)
    • TSH (Thyroid-Stimulating Hormone): 0.4-4.0 mIU/L (normal range indicates proper thyroid regulation and function)
    • Total T4 (Thyroxine): 4.5-12.0 mcg/dL (normal levels reflect adequate thyroid hormone production)
    • T3 (Triiodothyronine): 80-200 ng/dL (normal range ensures proper metabolic function)
    • AMH (Anti-Mullerian Hormone): 0.5-2.4 ng/mL (normal levels indicate adequate testicular reserve and Sertoli cell function)
    • Reference ranges may vary slightly between laboratories; consult your specific lab's reference values for accuracy
  • Interpretation
    • Elevated FSH (>8.6 mIU/mL) indicates primary testicular failure, impaired spermatogenesis, or testicular atrophy; suggests reduced sperm production capacity
    • Low FSH (<1.7 mIU/mL) suggests hypogonadotropic hypogonadism, pituitary insufficiency, or secondary hypogonadism requiring further investigation
    • Elevated LH (>8.6 mIU/mL) may indicate primary gonadal failure or resistance to testosterone, often accompanied by elevated FSH
    • Low LH (<1.7 mIU/mL) suggests secondary hypogonadism, pituitary or hypothalamic disorder, requiring testosterone and imaging evaluation
    • Elevated Prolactin (>18.0 ng/mL) causes sexual dysfunction, reduced libido, erectile dysfunction, and decreased testosterone; may indicate pituitary adenoma
    • Low Prolactin is rarely clinically significant but may occur with pituitary hypofunction
    • Elevated TSH (>4.0 mIU/L) indicates primary hypothyroidism, leading to decreased sexual function, reduced sperm motility, and impaired testosterone metabolism
    • Low TSH (<0.4 mIU/L) suggests hyperthyroidism or secondary hypothyroidism, causing tachycardia, anxiety, and reproductive dysfunction
    • Elevated Total T4 (>12.0 mcg/dL) indicates hyperthyroidism with increased metabolic rate affecting reproductive function
    • Low Total T4 (<4.5 mcg/dL) indicates hypothyroidism with decreased metabolic rate and impaired testicular function
    • Elevated T3 (>200 ng/dL) suggests hyperthyroidism or thyroiditis with reproductive complications
    • Low T3 (<80 ng/dL) indicates hypothyroidism or sick euthyroid syndrome affecting fertility
    • Elevated AMH (>2.4 ng/mL) is rare in males but may indicate Sertoli cell hyperfunction or testicular tumors
    • Low AMH (<0.5 ng/mL) indicates reduced testicular reserve, impaired spermatogenesis, or Sertoli cell dysfunction; poor prognosis for fertility
    • FSH and LH should be interpreted together; both elevated suggests primary testicular failure; both low suggests secondary hypogonadism
    • Timing of blood draw affects LH and FSH levels; samples should be drawn in the morning (8-11 AM) when hormone levels are most stable
    • Stress, medications (opioids, glucocorticoids), obesity, and recent illness can affect hormone levels and should be considered in interpretation
  • Associated Organs
    • FSH and LH evaluate the hypothalamic-pituitary-testicular axis, which regulates testosterone production and spermatogenesis
    • Prolactin assessment involves the anterior pituitary gland, which produces prolactin and regulates reproductive hormones
    • Testis is the primary organ evaluated through these hormonal markers; dysfunction leads to infertility, azoospermia, or oligospermia
    • Thyroid gland is assessed through TSH, T3, and T4; thyroid dysfunction affects metabolism, sexual function, and sperm production
    • Hypothalamus and pituitary gland control the entire reproductive hormone axis through GnRH, FSH, and LH secretion
    • Leydig cells in testis produce testosterone in response to LH stimulation; dysfunction causes low testosterone and infertility
    • Sertoli cells in seminiferous tubules produce AMH and are essential for spermatogenesis; damage leads to azoospermia
    • Abnormal FSH/LH may indicate hypothalamic hypogonadism requiring MRI imaging to rule out pituitary tumors or other CNS pathology
    • Elevated prolactin may indicate prolactinoma (pituitary adenoma), requiring imaging and potential neurosurgical intervention
    • Thyroid dysfunction complications include hypogonadism, erectile dysfunction, premature ejaculation, and reduced sperm quality
    • Low AMH may indicate chemotherapy damage, prior testicular trauma, varicocele, or age-related testicular decline
  • Follow-up Tests
    • If FSH/LH abnormal: Serum testosterone level to assess gonadal steroid production and confirm hypogonadism severity
    • If low FSH/LH suspected: MRI of pituitary to rule out adenomas, assess for structural abnormalities or hypopituitarism
    • If high FSH with low sperm count: Semen analysis repeat to confirm findings; genetic testing (karyotype, Y-chromosome microdeletion) to assess for chromosomal abnormalities
    • If prolactin elevated: Prolactin levels repeated to confirm; MRI pituitary to assess for prolactinoma; medication review for dopamine antagonists
    • If prolactin elevated: Free testosterone and bioavailable testosterone to assess true androgen status since prolactin affects testosterone metabolism
    • If TSH abnormal: Free T4, Free T3 to better characterize thyroid status; TPO antibodies and thyroid peroxidase antibodies to detect autoimmune thyroiditis
    • If hypothyroidism confirmed: Initiate thyroid replacement therapy; repeat TSH and T4 after 6-8 weeks to assess treatment adequacy
    • If low AMH detected: Testicular ultrasound to assess testicular volume, echogenicity, and rule out structural pathology
    • If low AMH with normal FSH/LH: Further evaluation for occult testicular dysfunction; consideration of testicular biopsy if azoospermia present
    • Monitoring frequency: Repeat hormone panel 4-6 weeks after treatment initiation to assess response; annual monitoring if on hormone replacement therapy
    • Semen analysis should always accompany this panel if infertility is the primary concern; essential for comprehensive fertility assessment
    • General health assessment: Metabolic panel, lipid profile, and glucose testing if hormonal abnormalities present; associated with increased cardiovascular risk
  • Fasting Required?
    • Fasting: NOT strictly required for this test panel, however a light, non-fatty meal is recommended
    • FSH, LH, and Prolactin: No fasting required; early morning collection (8-11 AM) preferred due to diurnal hormone variation
    • Thyroid Profile (TSH, Free T4, T3): No fasting required; results not significantly affected by food intake
    • Anti-Mullerian Hormone (AMH): No fasting required; no significant diurnal variation in levels
    • Medication considerations: Discontinue thyroid medications 6-8 hours before testing if TSH assessment is being done; continue all other chronic medications unless specifically instructed otherwise
    • Avoid medications that affect hormone levels: Stop dopamine antagonists, antipsychotics, and metoclopramide 24-48 hours before prolactin testing if possible
    • Nutritional supplements: Biotin-containing supplements should be discontinued 2-3 days before testing as biotin can interfere with immunoassays
    • Patient preparation: Avoid strenuous exercise 24 hours before collection; stress can elevate some hormones and affect results
    • Timing of collection: Schedule morning appointment between 7-11 AM for optimal hormone levels (FSH and LH peak in morning)
    • Hydration: Patient should remain well-hydrated; avoid excessive caffeine consumption on morning of test
    • No specific dietary restrictions required; light breakfast acceptable if needed to prevent faintness during phlebotomy

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