Mass -Medium Biopsy 1-3 cm
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Histopathological analysis
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🧪 What is Mass Biopsy (Medium 1–3 cm)?
A Mass Biopsy involves the removal of a 1–3 cm portion of an abnormal tissue mass (benign or malignant) from any part of the body for histopathological analysis.
- The mass could be in soft tissue, breast, thyroid, skin, gastrointestinal tract, reproductive organs, etc.
- The medium size refers to either the diameter of the mass being biopsied or the size of the tissue sample taken (1–3 cm).
❓ Why is the Test Done?
To:
- Diagnose the nature of a mass (benign vs malignant)
- Classify tumors (type, grade, origin)
- Evaluate suspicious growths or lumps
- Confirm cancer recurrence
- Guide treatment plans (surgery, chemotherapy, radiotherapy)
🧬 How is it Performed?
Type | Details |
|---|---|
Excisional biopsy | Entire 1–3 cm mass removed |
Incisional biopsy | Partial tissue sample taken |
Core needle biopsy | For deep/internal masses using a hollow needle |
Image-guided biopsy | CT/Ultrasound-guided for precise location |
Sample is sent for histopathology, and possibly IHC, genetic or molecular testing.
🧠 Associated Organs & Possible Diagnoses
Location | Possible Conditions |
|---|---|
Breast | Fibroadenoma, carcinoma |
Thyroid | Goiter, thyroid carcinoma |
GI tract | Polyps, GISTs, adenocarcinoma |
Skin/Subcutis | Lipoma, melanoma, sarcoma |
Uterus/Ovary | Fibroid, cyst, endometrial carcinoma, ovarian mass |
Lymph nodes | Lymphoma, TB, metastasis |
📈 Interpretation of Results
Histology Report | Meaning |
|---|---|
Benign | Non-cancerous lesion (e.g., lipoma, cyst) |
Malignant | Cancerous – requires grading, staging |
Inflammatory/Granuloma | Infection (e.g., TB), autoimmune inflammation |
Necrosis | Dead tissue – may suggest aggressive malignancy or infection |
Atypia/Dysplasia | Pre-cancerous or suspicious changes |
🔄 Related / Follow-Up Tests
- CBC, ESR, CRP – to evaluate systemic signs
- Immunohistochemistry (IHC) – tumor typing
- Molecular pathology / FISH / PCR – specific mutations
- CT/MRI/Ultrasound – for further staging or localization
- Tumor markers – based on mass origin (CEA, CA-125, PSA, etc.)
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
Mass Biopsy | ❌ Not required |
Fasting may be recommended only if sedation or general anesthesia is planned.
📝 Summary Table
Parameter | Details |
|---|---|
What | Removal of 1–3 cm tissue mass for microscopic analysis |
Why | Diagnose malignancy, type of mass, guide treatment |
Size Category | Medium biopsy (1–3 cm) |
Common Findings | Benign tumors, carcinoma, granulomas, necrosis |
Follow-up Tests | IHC, imaging, tumor markers, molecular tests |
Organs Affected | Any organ (skin, breast, GI, uterus, etc.) |
Fasting Required | ❌ No (unless anesthesia needed) |
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