Mumps Virus IgG antibody

Bacterial/ Viral

Report in 48Hrs

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No Fasting Required

Details

Detects IgG antibodies specific to the mumps virus in the blood

₹1,890₹3,150

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Mumps Virus IgG Antibody Test - Comprehensive Information Guide

Why is it done?
- Test Purpose: This test detects IgG antibodies against the mumps virus, indicating past infection, immunity, or successful vaccination against mumps.
- Primary Indications: Determining immunity status prior to vaccination or travel; confirming past mumps infection; screening healthcare workers, pregnant women, and immunocompromised individuals; investigating vaccination effectiveness.
- Typical Timing: Performed during routine pre-employment physicals, pre-travel screening, prenatal evaluations, outbreak investigations, or when acute mumps infection is suspected (used in conjunction with IgM antibodies).
Normal Range
- Reference Values: Negative/Non-reactive: <0.90 AU/mL or <1:10 titer (indicates no immunity) Borderline/Equivocal: 0.90-1.09 AU/mL (recommend retesting) Positive/Reactive: ≥1.10 AU/mL or ≥1:10 titer (indicates immunity)
- Units of Measurement: AU/mL (Arbitrary Units per milliliter) or reciprocal titer ratios (1:10, 1:20, 1:40, etc.); may also be reported as Index Value or Ratio.
- Interpretation Guide: Negative results indicate either no prior exposure to mumps or lack of vaccination; Positive results indicate immunity from previous infection or vaccination; Borderline results require repeat testing after 1-2 weeks to establish immunity status.
Interpretation
- Positive IgG Result: Indicates immunity to mumps from either past infection (can be determined by presence of IgM) or successful vaccination; protective immunity is generally considered lifelong; individual is not at risk for mumps infection.
- Negative IgG Result: Indicates no immunity to mumps; individual is susceptible to mumps infection; vaccination is recommended unless contraindicated; healthcare workers and pregnant women with negative results require immediate vaccination consideration.
- Borderline Result: Inconclusive findings requiring repeat testing; may indicate very recent seroconversion or declining antibody levels; clinical correlation with patient symptoms and timeline is essential.
- Factors Affecting Results: Immunocompromised status may result in false negatives; time since vaccination or infection affects antibody levels; recent MMR vaccine may cause temporary elevation; certain laboratory methods vary in sensitivity and specificity; passive transfer of antibodies in infants affects interpretation.
- Clinical Significance: IgG alone cannot differentiate acute from past infection; must be paired with IgM testing; acute infection shows rising IgG titers or conversion from negative to positive; chronic low-level positivity indicates prior immunity.
Associated Organs
- Primary Organ Systems: Salivary glands (parotid, submandibular, sublingual); pancreas; reproductive organs (testes, ovaries); central nervous system; inner ear.
- Associated Medical Conditions: Mumps (acute parotitis); mumps meningitis; mumps encephalitis; mumps orchitis (testicular inflammation); mumps oophoritis (ovarian inflammation); mumps pancreatitis; mumps-induced sensorineural hearing loss; mumps-related infertility.
- Diagnostic Applications: Confirms mumps infection; verifies immunity status; identifies vaccine responders; screens at-risk populations; supports outbreak investigations; assesses vaccination program effectiveness.
- Potential Complications with Mumps: Meningitis or encephalitis (1 in 400 cases); permanent hearing loss (1 in 20,000 cases); orchitis in 20-30% of post-pubertal males potentially causing infertility; oophoritis in 5% of post-pubertal females; pancreatitis (usually mild and self-limiting); myocarditis; arthritis; miscarriage if infection occurs in first trimester.
Follow-up Tests
- Recommended Based on Results: If negative: Mumps IgM antibody (to rule out acute infection); Mumps vaccination (if age-appropriate and not contraindicated) If borderline: Repeat mumps IgG test after 1-2 weeks; Mumps IgM antibody if acute infection suspected If positive: No additional testing needed unless acute infection suspected (then add IgM and RT-PCR)
- Complementary Immunology Tests: Measles IgG and Rubella IgG (complete MMR immunity profile); Varicella IgG; other viral serology for differential diagnosis.
- Molecular Testing: Mumps RT-PCR from saliva, CSF, or urine for acute infection confirmation; viral culture (if available); real-time PCR for genotyping.
- Clinical Follow-up: Post-vaccination verification: Re-test 4-8 weeks after MMR vaccination to confirm seroconversion; Occupational health: Annual screening for healthcare workers; Pregnancy: IgG confirmation in first trimester; Outbreak investigation: Serial IgG titers to document seroconversion.
- Monitoring Frequency: One-time screening for baseline immunity assessment; repeat testing after 2+ weeks if borderline results; post-vaccination testing at 4-8 weeks; periodic screening per occupational health protocols.
Fasting Required?
- Fasting Status: NO - Fasting is not required for this test.
- Sample Collection Requirements: 5-10 mL of venous blood collected in standard serum separator tube (SST) or equivalent; no special preparation needed prior to collection; test can be performed at any time of day.
- Patient Preparation Instructions: No fasting required; no dietary restrictions; normal medications may be taken as prescribed; patient may eat and drink normally before blood collection; patient identification and informed consent as per standard protocols.
- Medication Considerations: No medications need to be discontinued; immunosuppressive drugs may affect results (false negative); recent corticosteroid therapy may suppress antibody formation; blood transfusions in preceding 4 weeks may affect results.
- Timing Considerations: Avoid collection within 4 weeks of receiving MMR vaccine (may affect IgG interpretation); allow at least 3-4 weeks after acute mumps infection for optimal IgG antibody development; pregnant women should be tested before or early in pregnancy (not immediately after vaccine).

How our test process works!