Ovarian cyst -Large Biopsy 3-6 cm
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Confirm the nature of the ovarian cyst (functional, benign, borderline, or malignant)
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🧪 What is an Ovarian Cyst – Large Biopsy (3–6 cm)?
An ovarian cyst biopsy involves histopathological examination of a surgically removed ovarian cyst, usually between 3 to 6 cm in size, to determine its benign or malignant nature, composition, and underlying pathology.
Performed after:
- Laparoscopy or laparotomy
- Oophorectomy or cystectomy
❓ Why is the Biopsy Done?
To:
- Confirm the nature of the ovarian cyst (functional, benign, borderline, or malignant)
- Investigate persistent or complex cysts seen on imaging
- Evaluate cysts in postmenopausal women
- Diagnose endometriosis, teratoma, or epithelial tumors
- Guide further management (fertility preservation, staging surgery, etc.)
📏 Cyst Size: 3–6 cm
- Often classified as moderate to large
- Size alone doesn't confirm malignancy, but larger cysts with solid areas, septations, or papillary projections may raise concern
- Biopsy helps in confirming:
- Serous/mucinous cystadenoma
- Endometriotic cyst
- Dermoid cyst (mature teratoma)
- Borderline or malignant neoplasms
🔬 Histopathological Overview
Type | Description |
|---|---|
Functional cyst | Follicular or corpus luteum – benign |
Endometriotic cyst (chocolate cyst) | Endometrial tissue, dark fluid |
Dermoid (teratoma) | Contains hair, teeth, fat – mostly benign |
Serous/mucinous cystadenoma | Benign or borderline; lined by epithelium |
Ovarian carcinoma | Requires grading, IHC, and staging if suspected |
🧠 Associated Organs & Conditions
System | Conditions |
|---|---|
Ovaries | Benign cysts, endometriosis, neoplasms, PCOS |
Reproductive | Infertility, pelvic pain, menstrual irregularities |
Oncologic | Ovarian cancer (epithelial, germ cell, stromal tumors) |
🔄 Related / Follow-Up Tests
- CA-125, HE4 – tumor markers
- Transvaginal pelvic ultrasound / MRI
- Pap smear, HPV testing
- Hormonal profile (FSH, LH, Estradiol, AMH)
- IHC on biopsy – for precise tumor subtyping
- BRCA1/2 or genetic testing if cancer suspected
✅ Fasting Required?
Test Type | Fasting Required |
|---|---|
Histopathological biopsy | ❌ No, unless under anesthesia |
If done during surgery, 6–8 hours fasting is usually required for anesthesia purposes.
📝 Summary Table
Parameter | Details |
|---|---|
What | Histological evaluation of a 3–6 cm ovarian cyst |
Why | Diagnose type (benign/malignant), rule out cancer |
Common Findings | Dermoid, serous/mucinous cyst, endometriotic cyst |
Associated Conditions | Ovarian tumors, endometriosis, PCOS, malignancy |
Follow-up Tests | CA-125, USG/MRI, IHC, hormonal panel, BRCA testing |
Fasting Required | ❌ Not for test; ✅ Yes if under general anesthesia |
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