PBS for Schistocytes
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Indicators of microangiopathic hemolytic anemia (MAHA) and related serious conditions.
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🧪 What is PBS for Schistocytes?
Peripheral Blood Smear (PBS) for Schistocytes is a microscopic examination of stained blood to detect schistocytes—fragmented red blood cells (RBCs).
Schistocytes are hallmark indicators of microangiopathic hemolytic anemia (MAHA) and related serious conditions.
❓ Why is the Test Done?
To:
- Diagnose or monitor hemolytic anemia
- Identify microvascular damage or clotting disorders
- Evaluate unexplained anemia, low platelets, or jaundice
- Support diagnosis in critically ill or septic patients
🔬 What are Schistocytes?
Schistocytes are irregularly shaped, fragmented RBCs, often seen with:
- Helmet cells
- Triangular RBCs
- Small RBC fragments
They are formed when RBCs are sheared by fibrin strands in narrowed or damaged blood vessels.
📊 Interpretation of Results
Schistocyte % | Interpretation |
|---|---|
<0.5% | Normal |
0.5–1.0% | Borderline (may require repeat testing or clinical correlation) |
>1% | Suggestive of microangiopathic hemolytic anemia (MAHA) |
>2–3% | Strongly suggestive of TTP, DIC, or HUS |
Values are manually estimated by a pathologist per 1,000 RBCs.
🧠 Associated Conditions & Organs
System | Conditions Indicated by Schistocytes |
|---|---|
Hematologic | TTP (Thrombotic Thrombocytopenic Purpura), HUS, DIC, MAHA |
Renal | Hemolytic uremic syndrome, malignant hypertension |
Cardiovascular | Prosthetic heart valve hemolysis, vasculitis |
Liver | HELLP syndrome (in pregnancy), hepatic failure |
🔄 Related / Follow-Up Tests
- Complete Blood Count (CBC) with Reticulocyte Count
- LDH – elevated in hemolysis
- Haptoglobin – decreased in hemolysis
- Indirect Bilirubin – elevated
- Coagulation profile (PT, aPTT, D-dimer) – for DIC
- ADAMTS13 activity – for TTP
- Kidney function tests (KFT) – for HUS
- Peripheral smear – repeat for monitoring
✅ Fasting Required?
Test | Fasting Requirement |
|---|---|
PBS for Schistocytes | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Microscopic exam of RBCs to detect schistocytes |
Why | Evaluate for hemolysis, TTP, HUS, DIC |
Normal | <0.5% schistocytes |
Abnormal | >1% indicates MAHA-related conditions |
Follow-up Tests | CBC, LDH, bilirubin, haptoglobin, coagulation tests |
Associated Conditions | TTP, HUS, DIC, HELLP, mechanical heart valve hemolysis |
Fasting Required | ❌ No |
How our test process works!
