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Procalcitonin

Unit Test
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Procalcitonin is a peptide precursor of the hormone calcitonin, normally produced in the thyroid

13503025

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🧪 What is Procalcitonin (PCT)?

Procalcitonin is a peptide precursor of the hormone calcitonin, normally produced in the thyroid. During systemic bacterial infections and sepsis, PCT levels rise significantly in the blood, making it a useful biomarker for bacterial infections and sepsis.

❓ Why is the Test Done?

To:

  • Diagnose and assess severity of bacterial infections and sepsis
  • Differentiate between bacterial and viral infections
  • Guide antibiotic therapy decisions (start/stop)
  • Monitor response to treatment in critically ill patients
  • Detect post-surgical or traumatic infections

📊 Normal Range

Procalcitonin Level (ng/mL)

Interpretation

< 0.05

Normal or no bacterial infection

0.05 – 0.5

Low risk; localized infection possible

0.5 – 2.0

Moderate risk; systemic bacterial infection

> 2.0

High risk; severe sepsis or septic shock

📈 Interpretation of Results

Level

Clinical Implication

Low (<0.05)

Bacterial infection unlikely

Mild elevation

Possible localized bacterial infection

Moderate elevation

Suggests systemic bacterial infection/sepsis

High (>2.0)

Severe sepsis, septic shock, poor prognosis

🧠 Associated Conditions

Condition

Details

Bacterial sepsis

Strongly elevated PCT

Severe bacterial infections

Pneumonia, meningitis, pyelonephritis

Postoperative infections

Elevated PCT can indicate surgical site infection

Non-bacterial causes

Trauma, surgery, burns may mildly elevate PCT

Viral infections

Usually low PCT levels

🔄 Related / Follow-Up Tests

  • Blood cultures
  • CRP (C-reactive protein)
  • CBC with differential
  • Lactate – for sepsis severity
  • Imaging studies – to locate infection source

✅ Fasting Required?

Test

Fasting Required

Procalcitonin

No

📝 Summary Table

Parameter

Details

What

Biomarker indicating bacterial infection and sepsis

Why

Diagnose, assess severity, and guide treatment in infection

Normal Range

<0.05 ng/mL

Elevated Levels

Indicate bacterial infection, sepsis severity

Associated Conditions

Bacterial sepsis, pneumonia, postoperative infection

Follow-up Tests

Blood cultures, CRP, CBC, lactate, imaging

Fasting Required

❌ No

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