Protein C Activity
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Measures the functional activity of Protein C in the blood, assessing its ability to regulate clot formation
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🧪 What is Protein C Activity?
Protein C is a vitamin K–dependent plasma protein that plays a crucial role in regulating blood coagulation by inactivating factors Va and VIIIa, thus acting as a natural anticoagulant.
The Protein C Activity test measures the functional activity of Protein C in the blood, assessing its ability to regulate clot formation.
❓ Why is the Test Done?
To:
- Diagnose Protein C deficiency (hereditary or acquired), which increases risk of venous thromboembolism (VTE)
- Investigate unexplained or recurrent blood clots
- Assess thrombophilia (tendency to clot)
- Monitor response to anticoagulant therapy
- Evaluate disseminated intravascular coagulation (DIC) or liver disease impact
📊 Normal Range
Protein C Activity | Reference Range |
|---|---|
Adults | 70% – 140% (varies by lab) |
📈 Interpretation of Results
Result | Possible Meaning |
|---|---|
Low Protein C Activity | Indicates Protein C deficiency → increased thrombosis risk |
Normal or High Activity | Normal coagulation regulation |
Acquired deficiency | Due to liver disease, DIC, vitamin K deficiency, warfarin therapy |
🧠 Associated Conditions
System/Organ | Conditions |
|---|---|
Hematologic | Venous thromboembolism, deep vein thrombosis, pulmonary embolism |
Liver | Liver disease (reduced synthesis) |
Coagulation system | DIC, vitamin K deficiency, warfarin effect |
🔄 Related / Follow-Up Tests
- Protein S Activity
- Antithrombin III levels
- Factor V Leiden mutation analysis
- Prothrombin gene mutation
- Coagulation profile (PT, aPTT)
- D-dimer
✅ Fasting Required?
Test | Fasting Required |
|---|---|
Protein C Activity | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures functional activity of natural anticoagulant Protein C |
Why | Evaluate thrombophilia and risk of blood clots |
Normal Range | 70% – 140% activity |
Low Levels | Hereditary or acquired Protein C deficiency |
Associated Conditions | Venous thrombosis, liver disease, DIC, vitamin K deficiency |
Follow-up Tests | Protein S, antithrombin III, genetic tests, coagulation studies |
Fasting Required | ❌ No |
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